Effectiveness of Abbott BinaxNOW Rapid Antigen Test for Detection of SARS-CoV-2 Infections in Outbreak among Horse Racetrack Workers, California, USA
The Abbott BinaxNOW rapid antigen test is cheaper and faster than real-time reverse transcription PCR (rRT-PCR) for detecting severe acute respiratory syndrome coronavirus 2. We compared BinaxNOW with rRT-PCR in 769 paired specimens from 342 persons during a coronavirus disease outbreak among horse...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2021-11-01
|
| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/27/11/21-1449_article |
| _version_ | 1818975265900986368 |
|---|---|
| author | Krishna Surasi Kristin J. Cummings Carl Hanson Mary Kate Morris Maria Salas David Seftel Liza Ortiz Ruwan Thilakaratne Cameron Stainken Debra A. Wadford |
| author_facet | Krishna Surasi Kristin J. Cummings Carl Hanson Mary Kate Morris Maria Salas David Seftel Liza Ortiz Ruwan Thilakaratne Cameron Stainken Debra A. Wadford |
| author_sort | Krishna Surasi |
| collection | DOAJ |
| description | The Abbott BinaxNOW rapid antigen test is cheaper and faster than real-time reverse transcription PCR (rRT-PCR) for detecting severe acute respiratory syndrome coronavirus 2. We compared BinaxNOW with rRT-PCR in 769 paired specimens from 342 persons during a coronavirus disease outbreak among horse racetrack workers in California, USA. We found positive percent agreement was 43.3% (95% CI 34.6%–52.4%), negative percent agreement 100% (95% CI 99.4%–100%), positive predictive value 100% (95% CI 93.5%–100%), and negative predictive value 89.9% (95% CI 87.5%–92.0%). Among 127 rRT-PCR–positive specimens, the 55 with paired BinaxNOW-positive results had a lower mean cycle threshold than the 72 with paired BinaxNOW-negative results (17.8 vs. 28.5; p<0.001). Of 100 specimens with cycle threshold <30, a total of 51 resulted in positive virus isolation; 45 (88.2%) of those were BinaxNOW-positive. Our comparison supports immediate isolation for BinaxNOW-positive persons and confirmatory testing for negative persons. |
| first_indexed | 2024-12-20T15:53:13Z |
| format | Article |
| id | doaj.art-13bde606a1524cdb97a48a8eb96704d5 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-20T15:53:13Z |
| publishDate | 2021-11-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-13bde606a1524cdb97a48a8eb96704d52022-12-21T19:34:36ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592021-11-0127112761276710.3201/eid2711.211449Effectiveness of Abbott BinaxNOW Rapid Antigen Test for Detection of SARS-CoV-2 Infections in Outbreak among Horse Racetrack Workers, California, USAKrishna SurasiKristin J. CummingsCarl HansonMary Kate MorrisMaria SalasDavid SeftelLiza OrtizRuwan ThilakaratneCameron StainkenDebra A. WadfordThe Abbott BinaxNOW rapid antigen test is cheaper and faster than real-time reverse transcription PCR (rRT-PCR) for detecting severe acute respiratory syndrome coronavirus 2. We compared BinaxNOW with rRT-PCR in 769 paired specimens from 342 persons during a coronavirus disease outbreak among horse racetrack workers in California, USA. We found positive percent agreement was 43.3% (95% CI 34.6%–52.4%), negative percent agreement 100% (95% CI 99.4%–100%), positive predictive value 100% (95% CI 93.5%–100%), and negative predictive value 89.9% (95% CI 87.5%–92.0%). Among 127 rRT-PCR–positive specimens, the 55 with paired BinaxNOW-positive results had a lower mean cycle threshold than the 72 with paired BinaxNOW-negative results (17.8 vs. 28.5; p<0.001). Of 100 specimens with cycle threshold <30, a total of 51 resulted in positive virus isolation; 45 (88.2%) of those were BinaxNOW-positive. Our comparison supports immediate isolation for BinaxNOW-positive persons and confirmatory testing for negative persons.https://wwwnc.cdc.gov/eid/article/27/11/21-1449_articleCOVID-19coronavirus diseaseSARS-CoV-2severe acute respiratory syndrome coronavirus 2virusesrespiratory infections |
| spellingShingle | Krishna Surasi Kristin J. Cummings Carl Hanson Mary Kate Morris Maria Salas David Seftel Liza Ortiz Ruwan Thilakaratne Cameron Stainken Debra A. Wadford Effectiveness of Abbott BinaxNOW Rapid Antigen Test for Detection of SARS-CoV-2 Infections in Outbreak among Horse Racetrack Workers, California, USA Emerging Infectious Diseases COVID-19 coronavirus disease SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 viruses respiratory infections |
| title | Effectiveness of Abbott BinaxNOW Rapid Antigen Test for Detection of SARS-CoV-2 Infections in Outbreak among Horse Racetrack Workers, California, USA |
| title_full | Effectiveness of Abbott BinaxNOW Rapid Antigen Test for Detection of SARS-CoV-2 Infections in Outbreak among Horse Racetrack Workers, California, USA |
| title_fullStr | Effectiveness of Abbott BinaxNOW Rapid Antigen Test for Detection of SARS-CoV-2 Infections in Outbreak among Horse Racetrack Workers, California, USA |
| title_full_unstemmed | Effectiveness of Abbott BinaxNOW Rapid Antigen Test for Detection of SARS-CoV-2 Infections in Outbreak among Horse Racetrack Workers, California, USA |
| title_short | Effectiveness of Abbott BinaxNOW Rapid Antigen Test for Detection of SARS-CoV-2 Infections in Outbreak among Horse Racetrack Workers, California, USA |
| title_sort | effectiveness of abbott binaxnow rapid antigen test for detection of sars cov 2 infections in outbreak among horse racetrack workers california usa |
| topic | COVID-19 coronavirus disease SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 viruses respiratory infections |
| url | https://wwwnc.cdc.gov/eid/article/27/11/21-1449_article |
| work_keys_str_mv | AT krishnasurasi effectivenessofabbottbinaxnowrapidantigentestfordetectionofsarscov2infectionsinoutbreakamonghorseracetrackworkerscaliforniausa AT kristinjcummings effectivenessofabbottbinaxnowrapidantigentestfordetectionofsarscov2infectionsinoutbreakamonghorseracetrackworkerscaliforniausa AT carlhanson effectivenessofabbottbinaxnowrapidantigentestfordetectionofsarscov2infectionsinoutbreakamonghorseracetrackworkerscaliforniausa AT marykatemorris effectivenessofabbottbinaxnowrapidantigentestfordetectionofsarscov2infectionsinoutbreakamonghorseracetrackworkerscaliforniausa AT mariasalas effectivenessofabbottbinaxnowrapidantigentestfordetectionofsarscov2infectionsinoutbreakamonghorseracetrackworkerscaliforniausa AT davidseftel effectivenessofabbottbinaxnowrapidantigentestfordetectionofsarscov2infectionsinoutbreakamonghorseracetrackworkerscaliforniausa AT lizaortiz effectivenessofabbottbinaxnowrapidantigentestfordetectionofsarscov2infectionsinoutbreakamonghorseracetrackworkerscaliforniausa AT ruwanthilakaratne effectivenessofabbottbinaxnowrapidantigentestfordetectionofsarscov2infectionsinoutbreakamonghorseracetrackworkerscaliforniausa AT cameronstainken effectivenessofabbottbinaxnowrapidantigentestfordetectionofsarscov2infectionsinoutbreakamonghorseracetrackworkerscaliforniausa AT debraawadford effectivenessofabbottbinaxnowrapidantigentestfordetectionofsarscov2infectionsinoutbreakamonghorseracetrackworkerscaliforniausa |