Local and Systemic Alterations of the L-Arginine/Nitric Oxide Pathway in Sputum, Blood, and Urine of Pediatric Cystic Fibrosis Patients and Effects of Antibiotic Treatment

Local and Systemic Alterations of the L-Arginine/Nitric Oxide Pathway in Sputum, Blood, and Urine of Pediatric Cystic Fibrosis Patients and Effects of Antibiotic Treatment

Alterations in the L-arginine (Arg)/nitric oxide (NO) pathway have been reported in cystic fibrosis (CF; OMIM 219700) as the result of various factors including systemic and local inflammatory activity in the airways. The aim of the present study was to evaluate the Arg/NO metabolism in pediatric CF...

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Bibliographic Details
Main Authors: Beatrice Hanusch, Folke Brinkmann, Sebene Mayorandan, Kristine Chobanyan-Jürgens, Anna Wiemers, Kathrin Jansen, Manfred Ballmann, Anjona Schmidt-Choudhury, Alexander Bollenbach, Nico Derichs, Dimitrios Tsikas, Thomas Lücke
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Journal of Clinical Medicine
Subjects:
antibiotics
cystic fibrosis
inflammation
nitric oxide
<i>Pseudomonas aeruginosa</i>
Online Access:https://www.mdpi.com/2077-0383/9/12/3802

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