Deamination of 1-Aminoalkylphosphonic Acids: Reaction Intermediates and Selectivity
Deamination of 1-aminoalkylphosphonic acids in the reaction with HNO<sub>2</sub> (generated “in situ” from NaNO<sub>2</sub>) yields a mixture of substitution products (1-hydroxyalkylphosphonic acids), elimination products (vinylphosphonic acid derivatives), rearrangement and...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/24/8849 |
| Summary: | Deamination of 1-aminoalkylphosphonic acids in the reaction with HNO<sub>2</sub> (generated “in situ” from NaNO<sub>2</sub>) yields a mixture of substitution products (1-hydroxyalkylphosphonic acids), elimination products (vinylphosphonic acid derivatives), rearrangement and substitution products (2-hydroxylkylphosphonic acids) as well as H<sub>3</sub>PO<sub>4</sub>. The variety of formed reaction products suggests that 1-phosphonoalkylium ions may be intermediates in such deamination reactions. |
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| ISSN: | 1420-3049 |