Neutrophil extracellular traps regulating tumorimmunity in hepatocellular carcinoma
As a component of the innate immune system, there is emerging evidence to suggest that neutrophils may play a critical role in the initiation and progression of hepatocellular carcinoma (HCC). Neutrophil extracellular traps (NETs) are web-like chromatin structures that protrude from the membranes du...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1253964/full |
| _version_ | 1797387571545767936 |
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| author | Weixiong Zhu Weixiong Zhu Chuanlei Fan Shi Dong Shi Dong Xin Li Xin Li Haofei Chen Haofei Chen Wence Zhou Wence Zhou |
| author_facet | Weixiong Zhu Weixiong Zhu Chuanlei Fan Shi Dong Shi Dong Xin Li Xin Li Haofei Chen Haofei Chen Wence Zhou Wence Zhou |
| author_sort | Weixiong Zhu |
| collection | DOAJ |
| description | As a component of the innate immune system, there is emerging evidence to suggest that neutrophils may play a critical role in the initiation and progression of hepatocellular carcinoma (HCC). Neutrophil extracellular traps (NETs) are web-like chromatin structures that protrude from the membranes during neutrophil activation. Recent research has shown that NETs, which are at the forefront of the renewed interest in neutrophil studies, are increasingly intertwined with HCC. By exploring the mechanisms of NETs in HCC, we aim to improve our understanding of the role of NETs and gain deeper insights into neutrophil biology. Therefore, this article provides a summary of key findings and discusses the emerging field of NETs in HCC. |
| first_indexed | 2024-03-08T22:27:03Z |
| format | Article |
| id | doaj.art-13c27771bb5149428579d963536567eb |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T22:27:03Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-13c27771bb5149428579d963536567eb2023-12-18T09:51:25ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-12-011410.3389/fimmu.2023.12539641253964Neutrophil extracellular traps regulating tumorimmunity in hepatocellular carcinomaWeixiong Zhu0Weixiong Zhu1Chuanlei Fan2Shi Dong3Shi Dong4Xin Li5Xin Li6Haofei Chen7Haofei Chen8Wence Zhou9Wence Zhou10The Second Clinical Medical College, Lanzhou University, Lanzhou, ChinaDepartment of General Surgery, The Second Hospital of Lanzhou University, Lanzhou, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, ChinaThe Second Clinical Medical College, Lanzhou University, Lanzhou, ChinaDepartment of General Surgery, The Second Hospital of Lanzhou University, Lanzhou, ChinaThe Second Clinical Medical College, Lanzhou University, Lanzhou, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, ChinaThe Second Clinical Medical College, Lanzhou University, Lanzhou, ChinaDepartment of General Surgery, The Second Hospital of Lanzhou University, Lanzhou, ChinaThe Second Clinical Medical College, Lanzhou University, Lanzhou, ChinaDepartment of General Surgery, The Second Hospital of Lanzhou University, Lanzhou, ChinaAs a component of the innate immune system, there is emerging evidence to suggest that neutrophils may play a critical role in the initiation and progression of hepatocellular carcinoma (HCC). Neutrophil extracellular traps (NETs) are web-like chromatin structures that protrude from the membranes during neutrophil activation. Recent research has shown that NETs, which are at the forefront of the renewed interest in neutrophil studies, are increasingly intertwined with HCC. By exploring the mechanisms of NETs in HCC, we aim to improve our understanding of the role of NETs and gain deeper insights into neutrophil biology. Therefore, this article provides a summary of key findings and discusses the emerging field of NETs in HCC.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1253964/fullhepatocellular carcinoma (HCC)neutrophil extracellular trap (NET) formationtumorigenesis and progressionliver transplantationliver ischemia-reperfusion injury (liver I/R injury) |
| spellingShingle | Weixiong Zhu Weixiong Zhu Chuanlei Fan Shi Dong Shi Dong Xin Li Xin Li Haofei Chen Haofei Chen Wence Zhou Wence Zhou Neutrophil extracellular traps regulating tumorimmunity in hepatocellular carcinoma Frontiers in Immunology hepatocellular carcinoma (HCC) neutrophil extracellular trap (NET) formation tumorigenesis and progression liver transplantation liver ischemia-reperfusion injury (liver I/R injury) |
| title | Neutrophil extracellular traps regulating tumorimmunity in hepatocellular carcinoma |
| title_full | Neutrophil extracellular traps regulating tumorimmunity in hepatocellular carcinoma |
| title_fullStr | Neutrophil extracellular traps regulating tumorimmunity in hepatocellular carcinoma |
| title_full_unstemmed | Neutrophil extracellular traps regulating tumorimmunity in hepatocellular carcinoma |
| title_short | Neutrophil extracellular traps regulating tumorimmunity in hepatocellular carcinoma |
| title_sort | neutrophil extracellular traps regulating tumorimmunity in hepatocellular carcinoma |
| topic | hepatocellular carcinoma (HCC) neutrophil extracellular trap (NET) formation tumorigenesis and progression liver transplantation liver ischemia-reperfusion injury (liver I/R injury) |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1253964/full |
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