Sonographic Evaluation of Muscle Echogenicity for the Detection of Intensive Care Unit-Acquired Weakness: A Pilot Single-Center Prospective Cohort Study
Qualitative assessment by the Heckmatt scale (HS) and quantitative greyscale analysis of muscle echogenicity were compared for their value in detecting intensive care unit-acquired weakness (ICU-AW). We performed muscle ultrasound (MUS) of eight skeletal muscles on day 3 and day 10 after ICU admissi...
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MDPI AG
2022-06-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/6/1378 |
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| author | Felix Klawitter Uwe Walter Robert Patejdl Josefine Endler Daniel A. Reuter Johannes Ehler |
| author_facet | Felix Klawitter Uwe Walter Robert Patejdl Josefine Endler Daniel A. Reuter Johannes Ehler |
| author_sort | Felix Klawitter |
| collection | DOAJ |
| description | Qualitative assessment by the Heckmatt scale (HS) and quantitative greyscale analysis of muscle echogenicity were compared for their value in detecting intensive care unit-acquired weakness (ICU-AW). We performed muscle ultrasound (MUS) of eight skeletal muscles on day 3 and day 10 after ICU admission. We calculated the global mean greyscale score (MGS), the global mean z-score (MZS) and the global mean Heckmatt score (MHS). Longitudinal outcome was defined by the modified Rankin scale (mRS) and Barthel index (BI) after 100 days. In total, 652 ultrasound pictures from 38 critically ill patients (18 with and 20 without ICU-AW) and 10 controls were analyzed. Patients with ICU-AW had a higher MHS on day 10 compared to patients without ICU-AW (2.6 (0.4) vs. 2.2 (0.4), <i>p</i> = 0.006). The MHS was superior to ROC analysis (cut-off: 2.2, AUC: 0.79, <i>p</i> = 0.003, sensitivity 86%, specificity 60%) in detecting ICU-AW compared to MGS and MZS on day 10. The MHS correlated with the Medical Research Council sum score (MRC-SS) (r = −0.45, <i>p</i> = 0.004), the mRS (r = 0.45; <i>p</i> = 0.007) and BI (r = −0.38, <i>p</i> = 0.04) on day 100. Qualitative MUS analysis seems superior to quantitative greyscale analysis of muscle echogenicity for the detection of ICU-AW. |
| first_indexed | 2024-03-10T00:00:00Z |
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| language | English |
| last_indexed | 2024-03-10T00:00:00Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-13c2a6f2395847549a1d9b4b5329d54b2023-11-23T16:17:10ZengMDPI AGDiagnostics2075-44182022-06-01126137810.3390/diagnostics12061378Sonographic Evaluation of Muscle Echogenicity for the Detection of Intensive Care Unit-Acquired Weakness: A Pilot Single-Center Prospective Cohort StudyFelix Klawitter0Uwe Walter1Robert Patejdl2Josefine Endler3Daniel A. Reuter4Johannes Ehler5Department of Anesthesiology and Intensive Care Medicine, University Medical Center Rostock, 18057 Rostock, GermanyDepartment of Neurology, University Medical Center Rostock, 18147 Rostock, GermanyOscar Langendorff Institute of Physiology, University Medical Center Rostock, 18057 Rostock, GermanyDepartment of Anesthesiology and Intensive Care Medicine, University Medical Center Rostock, 18057 Rostock, GermanyDepartment of Anesthesiology and Intensive Care Medicine, University Medical Center Rostock, 18057 Rostock, GermanyDepartment of Anesthesiology and Intensive Care Medicine, University Medical Center Rostock, 18057 Rostock, GermanyQualitative assessment by the Heckmatt scale (HS) and quantitative greyscale analysis of muscle echogenicity were compared for their value in detecting intensive care unit-acquired weakness (ICU-AW). We performed muscle ultrasound (MUS) of eight skeletal muscles on day 3 and day 10 after ICU admission. We calculated the global mean greyscale score (MGS), the global mean z-score (MZS) and the global mean Heckmatt score (MHS). Longitudinal outcome was defined by the modified Rankin scale (mRS) and Barthel index (BI) after 100 days. In total, 652 ultrasound pictures from 38 critically ill patients (18 with and 20 without ICU-AW) and 10 controls were analyzed. Patients with ICU-AW had a higher MHS on day 10 compared to patients without ICU-AW (2.6 (0.4) vs. 2.2 (0.4), <i>p</i> = 0.006). The MHS was superior to ROC analysis (cut-off: 2.2, AUC: 0.79, <i>p</i> = 0.003, sensitivity 86%, specificity 60%) in detecting ICU-AW compared to MGS and MZS on day 10. The MHS correlated with the Medical Research Council sum score (MRC-SS) (r = −0.45, <i>p</i> = 0.004), the mRS (r = 0.45; <i>p</i> = 0.007) and BI (r = −0.38, <i>p</i> = 0.04) on day 100. Qualitative MUS analysis seems superior to quantitative greyscale analysis of muscle echogenicity for the detection of ICU-AW.https://www.mdpi.com/2075-4418/12/6/1378diagnostic ultrasoundICU-AWmuscle echogenicitymuscle weakness |
| spellingShingle | Felix Klawitter Uwe Walter Robert Patejdl Josefine Endler Daniel A. Reuter Johannes Ehler Sonographic Evaluation of Muscle Echogenicity for the Detection of Intensive Care Unit-Acquired Weakness: A Pilot Single-Center Prospective Cohort Study Diagnostics diagnostic ultrasound ICU-AW muscle echogenicity muscle weakness |
| title | Sonographic Evaluation of Muscle Echogenicity for the Detection of Intensive Care Unit-Acquired Weakness: A Pilot Single-Center Prospective Cohort Study |
| title_full | Sonographic Evaluation of Muscle Echogenicity for the Detection of Intensive Care Unit-Acquired Weakness: A Pilot Single-Center Prospective Cohort Study |
| title_fullStr | Sonographic Evaluation of Muscle Echogenicity for the Detection of Intensive Care Unit-Acquired Weakness: A Pilot Single-Center Prospective Cohort Study |
| title_full_unstemmed | Sonographic Evaluation of Muscle Echogenicity for the Detection of Intensive Care Unit-Acquired Weakness: A Pilot Single-Center Prospective Cohort Study |
| title_short | Sonographic Evaluation of Muscle Echogenicity for the Detection of Intensive Care Unit-Acquired Weakness: A Pilot Single-Center Prospective Cohort Study |
| title_sort | sonographic evaluation of muscle echogenicity for the detection of intensive care unit acquired weakness a pilot single center prospective cohort study |
| topic | diagnostic ultrasound ICU-AW muscle echogenicity muscle weakness |
| url | https://www.mdpi.com/2075-4418/12/6/1378 |
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