Idiopathic and radiation-induced myxofibrosarcoma in the head and neck—case report and literature review
Abstract Background Myxofibrosarcoma (MFS), especially radiation-Induced MFS (RIMFS) in the head and neck, is an extremely rare malignant fibroblastic tumor. The diagnosis and treatment of MFS remain great challenges. In the present study, we presented one case of RIMFS. Combined with previous liter...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-11-01
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| Series: | Chinese Neurosurgical Journal |
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| Online Access: | https://doi.org/10.1186/s41016-021-00267-9 |
| _version_ | 1818405569703182336 |
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| author | Bin Zhang Miao Bai Runfa Tian Shuyu Hao |
| author_facet | Bin Zhang Miao Bai Runfa Tian Shuyu Hao |
| author_sort | Bin Zhang |
| collection | DOAJ |
| description | Abstract Background Myxofibrosarcoma (MFS), especially radiation-Induced MFS (RIMFS) in the head and neck, is an extremely rare malignant fibroblastic tumor. The diagnosis and treatment of MFS remain great challenges. In the present study, we presented one case of RIMFS. Combined with previous literature, the clinical features, essentials of diagnosis, and treatment modalities of MFS in the head and neck were reviewed to better understand this rare entity. Case presentation We reported a case of RIMFS under the left occipital scalp in a 20-year-old girl with a history of medulloblastoma surgery and radiotherapy in 2006. A total tumor resection was performed with preservation of the overlying scalp the underlying bone, and no adjuvant therapy was administered after the first operation. The postoperative pathological diagnosis was high-grade MFS. The tumor relapsed 6 months later, and then, a planned extensive resection with negative surgical margins was carried out, followed by radiotherapy. No relapse occurred in a 12-month postoperative follow-up. Conclusions Planned gross total resection (GTR) with negative margins is the reasonable choice and footstone of other treatments for MFS. Ill-defined infiltrated borders and the complicated structures make it a great trouble to achieve total resection of MFS in the head and neck, so adjuvant radiotherapy and chemotherapy seem more necessary for these lesions. |
| first_indexed | 2024-12-14T08:58:08Z |
| format | Article |
| id | doaj.art-13c3742fb3d44017a54c42f0dd3cd3bd |
| institution | Directory Open Access Journal |
| issn | 2057-4967 |
| language | English |
| last_indexed | 2024-12-14T08:58:08Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Chinese Neurosurgical Journal |
| spelling | doaj.art-13c3742fb3d44017a54c42f0dd3cd3bd2022-12-21T23:08:52ZengBMCChinese Neurosurgical Journal2057-49672021-11-01711810.1186/s41016-021-00267-9Idiopathic and radiation-induced myxofibrosarcoma in the head and neck—case report and literature reviewBin Zhang0Miao Bai1Runfa Tian2Shuyu Hao3Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical UniversityDepartment of Neurology, Tang Du Hospital, Air Force Medical UniversityDepartment of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical UniversityAbstract Background Myxofibrosarcoma (MFS), especially radiation-Induced MFS (RIMFS) in the head and neck, is an extremely rare malignant fibroblastic tumor. The diagnosis and treatment of MFS remain great challenges. In the present study, we presented one case of RIMFS. Combined with previous literature, the clinical features, essentials of diagnosis, and treatment modalities of MFS in the head and neck were reviewed to better understand this rare entity. Case presentation We reported a case of RIMFS under the left occipital scalp in a 20-year-old girl with a history of medulloblastoma surgery and radiotherapy in 2006. A total tumor resection was performed with preservation of the overlying scalp the underlying bone, and no adjuvant therapy was administered after the first operation. The postoperative pathological diagnosis was high-grade MFS. The tumor relapsed 6 months later, and then, a planned extensive resection with negative surgical margins was carried out, followed by radiotherapy. No relapse occurred in a 12-month postoperative follow-up. Conclusions Planned gross total resection (GTR) with negative margins is the reasonable choice and footstone of other treatments for MFS. Ill-defined infiltrated borders and the complicated structures make it a great trouble to achieve total resection of MFS in the head and neck, so adjuvant radiotherapy and chemotherapy seem more necessary for these lesions.https://doi.org/10.1186/s41016-021-00267-9MyxofibrosarcomaHead and neckPlanned surgeryGross total resectionBin Zhang and Miao Bai are co-first authors |
| spellingShingle | Bin Zhang Miao Bai Runfa Tian Shuyu Hao Idiopathic and radiation-induced myxofibrosarcoma in the head and neck—case report and literature review Chinese Neurosurgical Journal Myxofibrosarcoma Head and neck Planned surgery Gross total resection Bin Zhang and Miao Bai are co-first authors |
| title | Idiopathic and radiation-induced myxofibrosarcoma in the head and neck—case report and literature review |
| title_full | Idiopathic and radiation-induced myxofibrosarcoma in the head and neck—case report and literature review |
| title_fullStr | Idiopathic and radiation-induced myxofibrosarcoma in the head and neck—case report and literature review |
| title_full_unstemmed | Idiopathic and radiation-induced myxofibrosarcoma in the head and neck—case report and literature review |
| title_short | Idiopathic and radiation-induced myxofibrosarcoma in the head and neck—case report and literature review |
| title_sort | idiopathic and radiation induced myxofibrosarcoma in the head and neck case report and literature review |
| topic | Myxofibrosarcoma Head and neck Planned surgery Gross total resection Bin Zhang and Miao Bai are co-first authors |
| url | https://doi.org/10.1186/s41016-021-00267-9 |
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