Narcolepsy in pediatric age – Experience of a tertiary pediatric hospital
Narcolepsy, a chronic disorder of the sleep–wake cycle of multifactorial etiology, is characterized by excessive daytime sleepiness, often associated with cataplexy, hypnagogic/hypnopompic hallucinations and sleep paralysis. Both early clinical suspicion and therapeutic approach are essential for pr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações Ltda.
2014-03-01
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| Series: | Sleep Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1984006314000236 |
| _version_ | 1797329275280424960 |
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| author | Filipa Dias Costa Maria Inês Barreto Vanda Clemente Mónica Vasconcelos Maria Helena Estêvão Núria Madureira |
| author_facet | Filipa Dias Costa Maria Inês Barreto Vanda Clemente Mónica Vasconcelos Maria Helena Estêvão Núria Madureira |
| author_sort | Filipa Dias Costa |
| collection | DOAJ |
| description | Narcolepsy, a chronic disorder of the sleep–wake cycle of multifactorial etiology, is characterized by excessive daytime sleepiness, often associated with cataplexy, hypnagogic/hypnopompic hallucinations and sleep paralysis. Both early clinical suspicion and therapeutic approach are essential for promotion of cognitive development and social integration of these children. The authors present a descriptive retrospective study of a series of eight children in whom symptoms first started between 6.8 and 10.5 years of age. Diagnostic delay ranged from 4 months to 2 years. One child had H1N1 flu vaccination eight months before the clinical onset. The first multiple sleep latency test was positive in 6 of 8 cases. All cases were treated with methylphenidate, and venlafaxine was associated in 4 of them. In one case the initial therapy was exclusively behavioral. In all cases, symptomatic improvement, better school performance and social integration were achieved after therapeutic adjustment. |
| first_indexed | 2024-03-08T07:02:26Z |
| format | Article |
| id | doaj.art-13c571be12544a2bacaaefe578e6f08f |
| institution | Directory Open Access Journal |
| issn | 1984-0063 |
| language | English |
| last_indexed | 2024-03-08T07:02:26Z |
| publishDate | 2014-03-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | Sleep Science |
| spelling | doaj.art-13c571be12544a2bacaaefe578e6f08f2024-02-03T05:18:27ZengThieme Revinter Publicações Ltda.Sleep Science1984-00632014-03-0171535810.1016/j.slsci.2014.07.022Narcolepsy in pediatric age – Experience of a tertiary pediatric hospitalFilipa Dias Costa0Maria Inês Barreto1Vanda Clemente2Mónica Vasconcelos3Maria Helena Estêvão4Núria Madureira5Pediatric Hospital, Hospital and University Center of Coimbra, PortugalPediatric Hospital, Hospital and University Center of Coimbra, PortugalLaboratory of Sleep and Ventilation, Pediatric Hospital, Hospital and University Center of Coimbra, PortugalCenter of Child Development, Pediatric Hospital, Hospital and University Center of Coimbra, PortugalLaboratory of Sleep and Ventilation, Pediatric Hospital, Hospital and University Center of Coimbra, PortugalLaboratory of Sleep and Ventilation, Pediatric Hospital, Hospital and University Center of Coimbra, PortugalNarcolepsy, a chronic disorder of the sleep–wake cycle of multifactorial etiology, is characterized by excessive daytime sleepiness, often associated with cataplexy, hypnagogic/hypnopompic hallucinations and sleep paralysis. Both early clinical suspicion and therapeutic approach are essential for promotion of cognitive development and social integration of these children. The authors present a descriptive retrospective study of a series of eight children in whom symptoms first started between 6.8 and 10.5 years of age. Diagnostic delay ranged from 4 months to 2 years. One child had H1N1 flu vaccination eight months before the clinical onset. The first multiple sleep latency test was positive in 6 of 8 cases. All cases were treated with methylphenidate, and venlafaxine was associated in 4 of them. In one case the initial therapy was exclusively behavioral. In all cases, symptomatic improvement, better school performance and social integration were achieved after therapeutic adjustment.http://www.sciencedirect.com/science/article/pii/S1984006314000236NarcolepsySleepinessChildrenCasuistic |
| spellingShingle | Filipa Dias Costa Maria Inês Barreto Vanda Clemente Mónica Vasconcelos Maria Helena Estêvão Núria Madureira Narcolepsy in pediatric age – Experience of a tertiary pediatric hospital Sleep Science Narcolepsy Sleepiness Children Casuistic |
| title | Narcolepsy in pediatric age – Experience of a tertiary pediatric hospital |
| title_full | Narcolepsy in pediatric age – Experience of a tertiary pediatric hospital |
| title_fullStr | Narcolepsy in pediatric age – Experience of a tertiary pediatric hospital |
| title_full_unstemmed | Narcolepsy in pediatric age – Experience of a tertiary pediatric hospital |
| title_short | Narcolepsy in pediatric age – Experience of a tertiary pediatric hospital |
| title_sort | narcolepsy in pediatric age experience of a tertiary pediatric hospital |
| topic | Narcolepsy Sleepiness Children Casuistic |
| url | http://www.sciencedirect.com/science/article/pii/S1984006314000236 |
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