Biomimetic Hierarchical Nanocomposite Hydrogels: From Design to Biomedical Applications
Natural extracellular matrix (ECM) is highly heterogeneous and anisotropic due to the existence of biomacromolecule bundles and pores. Hydrogels have been proposed as ideal carriers for therapeutic cells and drugs in tissue engineering and regenerative medicine. However, most of the homogeneous and...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Journal of Composites Science |
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| Online Access: | https://www.mdpi.com/2504-477X/6/11/340 |
| _version_ | 1797467696776871936 |
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| author | Zhi Yao Jiankun Xu Jun Shen Ling Qin Weihao Yuan |
| author_facet | Zhi Yao Jiankun Xu Jun Shen Ling Qin Weihao Yuan |
| author_sort | Zhi Yao |
| collection | DOAJ |
| description | Natural extracellular matrix (ECM) is highly heterogeneous and anisotropic due to the existence of biomacromolecule bundles and pores. Hydrogels have been proposed as ideal carriers for therapeutic cells and drugs in tissue engineering and regenerative medicine. However, most of the homogeneous and isotropic hydrogels cannot fully emulate the hierarchical properties of natural ECM, including the dynamically spatiotemporal distributions of biochemical and biomechanical signals. Biomimetic hierarchical nanocomposite hydrogels have emerged as potential candidates to better recapitulate natural ECM by introducing various nanostructures, such as nanoparticles, nanorods, and nanofibers. Moreover, the nanostructures in nanocomposite hydrogels can be engineered as stimuli-responsive actuators to realize the desirable control of hydrogel properties, thereby manipulating the behaviors of the encapsulated cells upon appropriate external stimuli. In this review, we present a comprehensive summary of the main strategies to construct biomimetic hierarchical nanocomposite hydrogels with an emphasis on the rational design of local hydrogel properties and their stimuli-responsibility. We then highlight cell fate decisions in engineered nanocomposite niches and their recent development and challenges in biomedical applications. |
| first_indexed | 2024-03-09T18:57:22Z |
| format | Article |
| id | doaj.art-13c75ffdec724aac9a84744cd4576ab2 |
| institution | Directory Open Access Journal |
| issn | 2504-477X |
| language | English |
| last_indexed | 2024-03-09T18:57:22Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Composites Science |
| spelling | doaj.art-13c75ffdec724aac9a84744cd4576ab22023-11-24T05:20:40ZengMDPI AGJournal of Composites Science2504-477X2022-11-0161134010.3390/jcs6110340Biomimetic Hierarchical Nanocomposite Hydrogels: From Design to Biomedical ApplicationsZhi Yao0Jiankun Xu1Jun Shen2Ling Qin3Weihao Yuan4Musculoskeletal Research Laboratory of Department of Orthopedics & Traumatology, Innovative Orthopaedic Biomaterial & Drug Translational Research Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong 999077, ChinaMusculoskeletal Research Laboratory of Department of Orthopedics & Traumatology, Innovative Orthopaedic Biomaterial & Drug Translational Research Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong 999077, ChinaDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USAMusculoskeletal Research Laboratory of Department of Orthopedics & Traumatology, Innovative Orthopaedic Biomaterial & Drug Translational Research Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong 999077, ChinaWeintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, School of Dentistry, University of California, Los Angeles, CA 90095, USANatural extracellular matrix (ECM) is highly heterogeneous and anisotropic due to the existence of biomacromolecule bundles and pores. Hydrogels have been proposed as ideal carriers for therapeutic cells and drugs in tissue engineering and regenerative medicine. However, most of the homogeneous and isotropic hydrogels cannot fully emulate the hierarchical properties of natural ECM, including the dynamically spatiotemporal distributions of biochemical and biomechanical signals. Biomimetic hierarchical nanocomposite hydrogels have emerged as potential candidates to better recapitulate natural ECM by introducing various nanostructures, such as nanoparticles, nanorods, and nanofibers. Moreover, the nanostructures in nanocomposite hydrogels can be engineered as stimuli-responsive actuators to realize the desirable control of hydrogel properties, thereby manipulating the behaviors of the encapsulated cells upon appropriate external stimuli. In this review, we present a comprehensive summary of the main strategies to construct biomimetic hierarchical nanocomposite hydrogels with an emphasis on the rational design of local hydrogel properties and their stimuli-responsibility. We then highlight cell fate decisions in engineered nanocomposite niches and their recent development and challenges in biomedical applications.https://www.mdpi.com/2504-477X/6/11/340nanocomposite hydrogelsnanostructuresdrug deliverytissue engineeringhierarchical |
| spellingShingle | Zhi Yao Jiankun Xu Jun Shen Ling Qin Weihao Yuan Biomimetic Hierarchical Nanocomposite Hydrogels: From Design to Biomedical Applications Journal of Composites Science nanocomposite hydrogels nanostructures drug delivery tissue engineering hierarchical |
| title | Biomimetic Hierarchical Nanocomposite Hydrogels: From Design to Biomedical Applications |
| title_full | Biomimetic Hierarchical Nanocomposite Hydrogels: From Design to Biomedical Applications |
| title_fullStr | Biomimetic Hierarchical Nanocomposite Hydrogels: From Design to Biomedical Applications |
| title_full_unstemmed | Biomimetic Hierarchical Nanocomposite Hydrogels: From Design to Biomedical Applications |
| title_short | Biomimetic Hierarchical Nanocomposite Hydrogels: From Design to Biomedical Applications |
| title_sort | biomimetic hierarchical nanocomposite hydrogels from design to biomedical applications |
| topic | nanocomposite hydrogels nanostructures drug delivery tissue engineering hierarchical |
| url | https://www.mdpi.com/2504-477X/6/11/340 |
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