Lipid remodeling of adipose tissue in metabolic health and disease
Abstract Adipose tissue is a dynamic and metabolically active organ that plays a crucial role in energy homeostasis and endocrine function. Recent advancements in lipidomics techniques have enabled the study of the complex lipid composition of adipose tissue and its role in metabolic disorders such...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-09-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-023-01071-4 |
| _version_ | 1797663583264309248 |
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| author | Yoon Keun Cho Sumin Lee Jaewon Lee Junsang Doh Joo-Hong Park Young-Suk Jung Yun-Hee Lee |
| author_facet | Yoon Keun Cho Sumin Lee Jaewon Lee Junsang Doh Joo-Hong Park Young-Suk Jung Yun-Hee Lee |
| author_sort | Yoon Keun Cho |
| collection | DOAJ |
| description | Abstract Adipose tissue is a dynamic and metabolically active organ that plays a crucial role in energy homeostasis and endocrine function. Recent advancements in lipidomics techniques have enabled the study of the complex lipid composition of adipose tissue and its role in metabolic disorders such as obesity, diabetes, and cardiovascular disease. In addition, adipose tissue lipidomics has emerged as a powerful tool for understanding the molecular mechanisms underlying these disorders and identifying bioactive lipid mediators and potential therapeutic targets. This review aims to summarize recent lipidomics studies that investigated the dynamic remodeling of adipose tissue lipids in response to specific physiological changes, pharmacological interventions, and pathological conditions. We discuss the molecular mechanisms of lipid remodeling in adipose tissue and explore the recent identification of bioactive lipid mediators generated in adipose tissue that regulate adipocytes and systemic metabolism. We propose that manipulating lipid-mediator metabolism could serve as a therapeutic approach for preventing or treating obesity-related metabolic diseases. |
| first_indexed | 2024-03-11T19:16:45Z |
| format | Article |
| id | doaj.art-13c9865b926447be8dd607789f298fe8 |
| institution | Directory Open Access Journal |
| issn | 2092-6413 |
| language | English |
| last_indexed | 2024-03-11T19:16:45Z |
| publishDate | 2023-09-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-13c9865b926447be8dd607789f298fe82023-10-08T11:07:57ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132023-09-015591955197310.1038/s12276-023-01071-4Lipid remodeling of adipose tissue in metabolic health and diseaseYoon Keun Cho0Sumin Lee1Jaewon Lee2Junsang Doh3Joo-Hong Park4Young-Suk Jung5Yun-Hee Lee6College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National UniversityCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National UniversityCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National UniversityDepartment of Materials Science and Engineering, Research Institute of Advanced Materials, Institute of Engineering Research, Bio-MAX Institute, Soft Foundry Institute, Seoul National UniversitySchool of Biological Sciences, Seoul National UniversityCollege of Pharmacy, Pusan National UniversityCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National UniversityAbstract Adipose tissue is a dynamic and metabolically active organ that plays a crucial role in energy homeostasis and endocrine function. Recent advancements in lipidomics techniques have enabled the study of the complex lipid composition of adipose tissue and its role in metabolic disorders such as obesity, diabetes, and cardiovascular disease. In addition, adipose tissue lipidomics has emerged as a powerful tool for understanding the molecular mechanisms underlying these disorders and identifying bioactive lipid mediators and potential therapeutic targets. This review aims to summarize recent lipidomics studies that investigated the dynamic remodeling of adipose tissue lipids in response to specific physiological changes, pharmacological interventions, and pathological conditions. We discuss the molecular mechanisms of lipid remodeling in adipose tissue and explore the recent identification of bioactive lipid mediators generated in adipose tissue that regulate adipocytes and systemic metabolism. We propose that manipulating lipid-mediator metabolism could serve as a therapeutic approach for preventing or treating obesity-related metabolic diseases.https://doi.org/10.1038/s12276-023-01071-4 |
| spellingShingle | Yoon Keun Cho Sumin Lee Jaewon Lee Junsang Doh Joo-Hong Park Young-Suk Jung Yun-Hee Lee Lipid remodeling of adipose tissue in metabolic health and disease Experimental and Molecular Medicine |
| title | Lipid remodeling of adipose tissue in metabolic health and disease |
| title_full | Lipid remodeling of adipose tissue in metabolic health and disease |
| title_fullStr | Lipid remodeling of adipose tissue in metabolic health and disease |
| title_full_unstemmed | Lipid remodeling of adipose tissue in metabolic health and disease |
| title_short | Lipid remodeling of adipose tissue in metabolic health and disease |
| title_sort | lipid remodeling of adipose tissue in metabolic health and disease |
| url | https://doi.org/10.1038/s12276-023-01071-4 |
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