Electrospun Poly(ε-caprolactone) Composite Nanofibers with Controlled Release of Cis-Diamminediiodoplatinum for a Higher Anticancer Activity
Abstract Poly(ε-caprolactone) (PCL) nanofibers were prepared by electrospun, on which the cis-diamminediiodoplatinum (cis-DIDP) was loaded, cis-DIDP@PCL, which effectively overcame cis-DIDP from dissociation or premature interaction with other bimolecular groups. Meanwhile, the toxicity and cross-re...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2017-04-01
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| Series: | Nanoscale Research Letters |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s11671-017-2092-y |
| _version_ | 1797707505877385216 |
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| author | Chaojing Mu Qingsheng Wu |
| author_facet | Chaojing Mu Qingsheng Wu |
| author_sort | Chaojing Mu |
| collection | DOAJ |
| description | Abstract Poly(ε-caprolactone) (PCL) nanofibers were prepared by electrospun, on which the cis-diamminediiodoplatinum (cis-DIDP) was loaded, cis-DIDP@PCL, which effectively overcame cis-DIDP from dissociation or premature interaction with other bimolecular groups. Meanwhile, the toxicity and cross-resistance of cis-DIDP were reduced greatly. In vitro, cis-DIDP released from the PCL nanofibers eradicated the tumor cells around twice times more than free cis-DIDP, even better than cisplatin. Furthermore, cis-DIDP@PCL could controllably release cis-DIDP in different sustained-release solution based on our experiment. |
| first_indexed | 2024-03-12T06:08:21Z |
| format | Article |
| id | doaj.art-13ca1b66400a41cc8e0aceb7ea528de1 |
| institution | Directory Open Access Journal |
| issn | 1931-7573 1556-276X |
| language | English |
| last_indexed | 2024-03-12T06:08:21Z |
| publishDate | 2017-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Nanoscale Research Letters |
| spelling | doaj.art-13ca1b66400a41cc8e0aceb7ea528de12023-09-03T03:21:38ZengSpringerOpenNanoscale Research Letters1931-75731556-276X2017-04-011211810.1186/s11671-017-2092-yElectrospun Poly(ε-caprolactone) Composite Nanofibers with Controlled Release of Cis-Diamminediiodoplatinum for a Higher Anticancer ActivityChaojing Mu0Qingsheng Wu1School of Chemical Science and Engineering, Shanghai Key Lab of Chemical Assessment and Sustainability, Tongji UniversitySchool of Chemical Science and Engineering, Shanghai Key Lab of Chemical Assessment and Sustainability, Tongji UniversityAbstract Poly(ε-caprolactone) (PCL) nanofibers were prepared by electrospun, on which the cis-diamminediiodoplatinum (cis-DIDP) was loaded, cis-DIDP@PCL, which effectively overcame cis-DIDP from dissociation or premature interaction with other bimolecular groups. Meanwhile, the toxicity and cross-resistance of cis-DIDP were reduced greatly. In vitro, cis-DIDP released from the PCL nanofibers eradicated the tumor cells around twice times more than free cis-DIDP, even better than cisplatin. Furthermore, cis-DIDP@PCL could controllably release cis-DIDP in different sustained-release solution based on our experiment.http://link.springer.com/article/10.1186/s11671-017-2092-yElectrospun nanofibersDrug carrierCis-diamminediiodoplatinumControlled releaseAnticancer reagent |
| spellingShingle | Chaojing Mu Qingsheng Wu Electrospun Poly(ε-caprolactone) Composite Nanofibers with Controlled Release of Cis-Diamminediiodoplatinum for a Higher Anticancer Activity Nanoscale Research Letters Electrospun nanofibers Drug carrier Cis-diamminediiodoplatinum Controlled release Anticancer reagent |
| title | Electrospun Poly(ε-caprolactone) Composite Nanofibers with Controlled Release of Cis-Diamminediiodoplatinum for a Higher Anticancer Activity |
| title_full | Electrospun Poly(ε-caprolactone) Composite Nanofibers with Controlled Release of Cis-Diamminediiodoplatinum for a Higher Anticancer Activity |
| title_fullStr | Electrospun Poly(ε-caprolactone) Composite Nanofibers with Controlled Release of Cis-Diamminediiodoplatinum for a Higher Anticancer Activity |
| title_full_unstemmed | Electrospun Poly(ε-caprolactone) Composite Nanofibers with Controlled Release of Cis-Diamminediiodoplatinum for a Higher Anticancer Activity |
| title_short | Electrospun Poly(ε-caprolactone) Composite Nanofibers with Controlled Release of Cis-Diamminediiodoplatinum for a Higher Anticancer Activity |
| title_sort | electrospun poly ε caprolactone composite nanofibers with controlled release of cis diamminediiodoplatinum for a higher anticancer activity |
| topic | Electrospun nanofibers Drug carrier Cis-diamminediiodoplatinum Controlled release Anticancer reagent |
| url | http://link.springer.com/article/10.1186/s11671-017-2092-y |
| work_keys_str_mv | AT chaojingmu electrospunpolyecaprolactonecompositenanofiberswithcontrolledreleaseofcisdiamminediiodoplatinumforahigheranticanceractivity AT qingshengwu electrospunpolyecaprolactonecompositenanofiberswithcontrolledreleaseofcisdiamminediiodoplatinumforahigheranticanceractivity |