Large-Scale Production of Human iPSC-Derived Macrophages for Drug Screening

Large-Scale Production of Human iPSC-Derived Macrophages for Drug Screening

Tissue-resident macrophages are key players in inflammatory processes, and their activation and functionality are crucial in health and disease. Numerous diseases are associated with alterations in homeostasis or dysregulation of the innate immune system, including allergic reactions, autoimmune dis...

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Bibliographic Details
Main Authors: Simon Gutbier, Florian Wanke, Nadine Dahm, Anna Rümmelin, Silke Zimmermann, Klaus Christensen, Fabian Köchl, Anna Rautanen, Klas Hatje, Barbara Geering, Jitao David Zhang, Markus Britschgi, Sally A. Cowley, Christoph Patsch
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
myeloid cells
primitive macrophages
induced pluripotent stem cells
in vitro characterization
drug discovery
disease modeling
Online Access:https://www.mdpi.com/1422-0067/21/13/4808

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