New progress in tumor treatment based on nanoparticles combined with irreversible electroporation
Abstract Nanoknife is a new tumor ablation technology. It forms nano permanent perforation on tumor cells by releasing high‐voltage pulses, destroying the intracellular balance and making cells apoptosis rapidly. So nano knife is also known as irreversible electroporation (IRE). IRE ablation technol...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2022-10-01
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| Series: | Nano Select |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/nano.202200064 |
| _version_ | 1811241239601741824 |
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| author | Lei Xu Liting Xie ChengYu Fang WenJing Lou Tianan Jiang |
| author_facet | Lei Xu Liting Xie ChengYu Fang WenJing Lou Tianan Jiang |
| author_sort | Lei Xu |
| collection | DOAJ |
| description | Abstract Nanoknife is a new tumor ablation technology. It forms nano permanent perforation on tumor cells by releasing high‐voltage pulses, destroying the intracellular balance and making cells apoptosis rapidly. So nano knife is also known as irreversible electroporation (IRE). IRE ablation technology and nanoparticles (NPs) have unique advantages in tumor treatment. Relevant studies have confirmed that NPs can enhance the effect of IRE ablation, expand the ablation boundary and reduce the threshold intensity of tumor cell perforation. Moreover, IRE combined with the drug‐loaded NPs can synergize tumor immunotherapy. Thus, the combination of NPs and IRE has broad research prospects. This paper reviews the mechanism of tumor treatment with NPs combined with IRE and discusses the future challenges and opportunities of combining these two technologies. |
| first_indexed | 2024-04-12T13:32:36Z |
| format | Article |
| id | doaj.art-13cb91ef8d884ae6b350e4c1bad737a1 |
| institution | Directory Open Access Journal |
| issn | 2688-4011 |
| language | English |
| last_indexed | 2024-04-12T13:32:36Z |
| publishDate | 2022-10-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Nano Select |
| spelling | doaj.art-13cb91ef8d884ae6b350e4c1bad737a12022-12-22T03:31:07ZengWiley-VCHNano Select2688-40112022-10-013101382139410.1002/nano.202200064New progress in tumor treatment based on nanoparticles combined with irreversible electroporationLei Xu0Liting Xie1ChengYu Fang2WenJing Lou3Tianan Jiang4Department of Ultrasound Medicine The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310000 P.R. ChinaDepartment of Ultrasound Medicine The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310000 P.R. ChinaDepartment of Ultrasound Medicine The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310000 P.R. ChinaDepartment of Ultrasound Medicine The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310000 P.R. ChinaDepartment of Ultrasound Medicine The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310000 P.R. ChinaAbstract Nanoknife is a new tumor ablation technology. It forms nano permanent perforation on tumor cells by releasing high‐voltage pulses, destroying the intracellular balance and making cells apoptosis rapidly. So nano knife is also known as irreversible electroporation (IRE). IRE ablation technology and nanoparticles (NPs) have unique advantages in tumor treatment. Relevant studies have confirmed that NPs can enhance the effect of IRE ablation, expand the ablation boundary and reduce the threshold intensity of tumor cell perforation. Moreover, IRE combined with the drug‐loaded NPs can synergize tumor immunotherapy. Thus, the combination of NPs and IRE has broad research prospects. This paper reviews the mechanism of tumor treatment with NPs combined with IRE and discusses the future challenges and opportunities of combining these two technologies.https://doi.org/10.1002/nano.202200064irreversible electroporationnanoparticlestumor |
| spellingShingle | Lei Xu Liting Xie ChengYu Fang WenJing Lou Tianan Jiang New progress in tumor treatment based on nanoparticles combined with irreversible electroporation Nano Select irreversible electroporation nanoparticles tumor |
| title | New progress in tumor treatment based on nanoparticles combined with irreversible electroporation |
| title_full | New progress in tumor treatment based on nanoparticles combined with irreversible electroporation |
| title_fullStr | New progress in tumor treatment based on nanoparticles combined with irreversible electroporation |
| title_full_unstemmed | New progress in tumor treatment based on nanoparticles combined with irreversible electroporation |
| title_short | New progress in tumor treatment based on nanoparticles combined with irreversible electroporation |
| title_sort | new progress in tumor treatment based on nanoparticles combined with irreversible electroporation |
| topic | irreversible electroporation nanoparticles tumor |
| url | https://doi.org/10.1002/nano.202200064 |
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