How Thymoquinone from <i>Nigella sativa</i> Accelerates Wound Healing through Multiple Mechanisms and Targets
Wound healing is a multifaceted process necessitating the collaboration of numerous elements to mend damaged tissue. Plant and animal-derived natural compounds have been utilized for wound treatment over the centuries, with many scientific investigations examining these compounds. Those with antioxi...
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| Format: | Article |
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MDPI AG
2023-11-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/45/11/567 |
| _version_ | 1797459648664567808 |
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| author | Abdalsalam Kmail Omar Said Bashar Saad |
| author_facet | Abdalsalam Kmail Omar Said Bashar Saad |
| author_sort | Abdalsalam Kmail |
| collection | DOAJ |
| description | Wound healing is a multifaceted process necessitating the collaboration of numerous elements to mend damaged tissue. Plant and animal-derived natural compounds have been utilized for wound treatment over the centuries, with many scientific investigations examining these compounds. Those with antioxidant, anti-inflammatory, and antibacterial properties are particularly noteworthy, as they target various wound-healing stages to expedite recovery. Thymoquinone, derived from <i>Nigella sativa</i> (<i>N. sativa</i>)—a medicinal herb with a long history of use in traditional medicine systems such as Unani, Ayurveda, Chinese, and Greco-Arabic and Islamic medicine—has demonstrated a range of therapeutic properties. Thymoquinone exhibits antimicrobial, anti-inflammatory, and antineoplastic activities, positioning it as a potential remedy for skin pathologies. This review examines recent research on how thymoquinone accelerates wound healing and the mechanisms behind its effectiveness. We carried out a comprehensive review of literature and electronic databases, including Google Scholar, PubMed, Science Direct, and MedlinePlus. Our aim was to gather relevant papers published between 2015 and August 2023. The main criteria for inclusion were that the articles had to be peer reviewed, original, written in English, and discuss the wound-healing parameters of thymoquinone in wound repair. Our review focused on the effects of thymoquinone on the cellular and molecular mechanisms involved in wound healing. We also examined the role of cytokines, signal transduction cascades, and clinical trials. We found sufficient evidence to support the effectiveness of thymoquinone in promoting wound healing. However, there is no consensus on the most effective concentrations of these substances. It is therefore essential to determine the optimal treatment doses and the best route of administration. Further research is also needed to investigate potential side effects and the performance of thymoquinone in clinical trials. |
| first_indexed | 2024-03-09T16:55:23Z |
| format | Article |
| id | doaj.art-13cd9db3566e47b49388a782b3b7e767 |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-09T16:55:23Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-13cd9db3566e47b49388a782b3b7e7672023-11-24T14:36:09ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452023-11-0145119039905910.3390/cimb45110567How Thymoquinone from <i>Nigella sativa</i> Accelerates Wound Healing through Multiple Mechanisms and TargetsAbdalsalam Kmail0Omar Said1Bashar Saad2Faculty of Sciences, Arab American University, Jenin P.O. Box 240, PalestineBeleaf Pharma, Kfar Kana 16930, IsraelQasemi Research Center, Al-Qasemi Academic College, Baqa Algharbiya 30100, IsraelWound healing is a multifaceted process necessitating the collaboration of numerous elements to mend damaged tissue. Plant and animal-derived natural compounds have been utilized for wound treatment over the centuries, with many scientific investigations examining these compounds. Those with antioxidant, anti-inflammatory, and antibacterial properties are particularly noteworthy, as they target various wound-healing stages to expedite recovery. Thymoquinone, derived from <i>Nigella sativa</i> (<i>N. sativa</i>)—a medicinal herb with a long history of use in traditional medicine systems such as Unani, Ayurveda, Chinese, and Greco-Arabic and Islamic medicine—has demonstrated a range of therapeutic properties. Thymoquinone exhibits antimicrobial, anti-inflammatory, and antineoplastic activities, positioning it as a potential remedy for skin pathologies. This review examines recent research on how thymoquinone accelerates wound healing and the mechanisms behind its effectiveness. We carried out a comprehensive review of literature and electronic databases, including Google Scholar, PubMed, Science Direct, and MedlinePlus. Our aim was to gather relevant papers published between 2015 and August 2023. The main criteria for inclusion were that the articles had to be peer reviewed, original, written in English, and discuss the wound-healing parameters of thymoquinone in wound repair. Our review focused on the effects of thymoquinone on the cellular and molecular mechanisms involved in wound healing. We also examined the role of cytokines, signal transduction cascades, and clinical trials. We found sufficient evidence to support the effectiveness of thymoquinone in promoting wound healing. However, there is no consensus on the most effective concentrations of these substances. It is therefore essential to determine the optimal treatment doses and the best route of administration. Further research is also needed to investigate potential side effects and the performance of thymoquinone in clinical trials.https://www.mdpi.com/1467-3045/45/11/567inflammationwound healinganti-bacterialmedicinal plants<i>Nigella sativa</i>natural product |
| spellingShingle | Abdalsalam Kmail Omar Said Bashar Saad How Thymoquinone from <i>Nigella sativa</i> Accelerates Wound Healing through Multiple Mechanisms and Targets Current Issues in Molecular Biology inflammation wound healing anti-bacterial medicinal plants <i>Nigella sativa</i> natural product |
| title | How Thymoquinone from <i>Nigella sativa</i> Accelerates Wound Healing through Multiple Mechanisms and Targets |
| title_full | How Thymoquinone from <i>Nigella sativa</i> Accelerates Wound Healing through Multiple Mechanisms and Targets |
| title_fullStr | How Thymoquinone from <i>Nigella sativa</i> Accelerates Wound Healing through Multiple Mechanisms and Targets |
| title_full_unstemmed | How Thymoquinone from <i>Nigella sativa</i> Accelerates Wound Healing through Multiple Mechanisms and Targets |
| title_short | How Thymoquinone from <i>Nigella sativa</i> Accelerates Wound Healing through Multiple Mechanisms and Targets |
| title_sort | how thymoquinone from i nigella sativa i accelerates wound healing through multiple mechanisms and targets |
| topic | inflammation wound healing anti-bacterial medicinal plants <i>Nigella sativa</i> natural product |
| url | https://www.mdpi.com/1467-3045/45/11/567 |
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