Increased incidence of live births in implanted day 5 versus day 6 blastocysts following single embryo transfers with PGT-A
Abstract Elective single-embryo transfers of euploid or low-level mosaic blastocysts were analyzed in this retrospective study to determine the correlations of live birth (LB) probability with embryonic developmental features of implanted day 5 (D5, n = 245) or day 6 (D6, n = 73) blastocysts using t...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-40052-5 |
| _version_ | 1797452698207911936 |
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| author | Chien-Hong Chen Chun-I Lee Chun-Chia Huang Hsiu-Hui Chen Chih-Ying Chang En-Hui Cheng Pin-Yao Lin Chung-I Chen Tsung-Hsien Lee Maw-Sheng Lee |
| author_facet | Chien-Hong Chen Chun-I Lee Chun-Chia Huang Hsiu-Hui Chen Chih-Ying Chang En-Hui Cheng Pin-Yao Lin Chung-I Chen Tsung-Hsien Lee Maw-Sheng Lee |
| author_sort | Chien-Hong Chen |
| collection | DOAJ |
| description | Abstract Elective single-embryo transfers of euploid or low-level mosaic blastocysts were analyzed in this retrospective study to determine the correlations of live birth (LB) probability with embryonic developmental features of implanted day 5 (D5, n = 245) or day 6 (D6, n = 73) blastocysts using time-lapse (TL) monitoring. According to the logistic regression analyses (adjusted odds ratio [OR] = 0.341, 95% confidence interval [CI] = 0.169–0.685, P < 0.05), the LB probability was negatively associated with the D6 group. The LB rate of the D5 group was higher than the D6 group (88.2% vs. 75.3%; P < 0.05). Compared with the D5 blastocysts, the D6 blastocysts exhibited comparable dysmorphisms except for the multinucleation at the 4-cell stage (10.9% vs. 2.9%, P < 0.05). Moreover, D6 blastocysts had considerably slower developmental kinetics and poorer blastocyst morphologies. Further analysis confirmed that the LB rate was not associated with developmental kinetics or dysmorphisms but rather with blastocyst morphology (inner cell mass [ICM] grade ≤ C vs. ICM grade A, adjusted OR = 0.155, 95% CI = 0.04–0.596, P < 0.05; trophectoderm [TE] grade ≤ C vs. TE grade A, adjusted OR = 0.157, 95% CI = 0.032–0.760, P < 0.05). In conclusion, D6 implanted blastocysts have a considerably lower LB rate than D5 implanted blastocysts. As determined by TL monitoring, the diminished blastocyst morphology can be one of the primary reasons underlying the decreased likelihood of LB. |
| first_indexed | 2024-03-09T15:12:25Z |
| format | Article |
| id | doaj.art-13d2ec45d2814fe38ab737d3d94316fb |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:12:25Z |
| publishDate | 2023-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-13d2ec45d2814fe38ab737d3d94316fb2023-11-26T13:16:08ZengNature PortfolioScientific Reports2045-23222023-08-0113111110.1038/s41598-023-40052-5Increased incidence of live births in implanted day 5 versus day 6 blastocysts following single embryo transfers with PGT-AChien-Hong Chen0Chun-I Lee1Chun-Chia Huang2Hsiu-Hui Chen3Chih-Ying Chang4En-Hui Cheng5Pin-Yao Lin6Chung-I Chen7Tsung-Hsien Lee8Maw-Sheng Lee9Division of Infertility, Lee Women’s HospitalDivision of Infertility, Lee Women’s HospitalDivision of Infertility, Lee Women’s HospitalDivision of Infertility, Lee Women’s HospitalDivision of Infertility, Lee Women’s HospitalDivision of Infertility, Lee Women’s HospitalDivision of Infertility, Lee Women’s HospitalDivision of Infertility, Lee Women’s HospitalDivision of Infertility, Lee Women’s HospitalDivision of Infertility, Lee Women’s HospitalAbstract Elective single-embryo transfers of euploid or low-level mosaic blastocysts were analyzed in this retrospective study to determine the correlations of live birth (LB) probability with embryonic developmental features of implanted day 5 (D5, n = 245) or day 6 (D6, n = 73) blastocysts using time-lapse (TL) monitoring. According to the logistic regression analyses (adjusted odds ratio [OR] = 0.341, 95% confidence interval [CI] = 0.169–0.685, P < 0.05), the LB probability was negatively associated with the D6 group. The LB rate of the D5 group was higher than the D6 group (88.2% vs. 75.3%; P < 0.05). Compared with the D5 blastocysts, the D6 blastocysts exhibited comparable dysmorphisms except for the multinucleation at the 4-cell stage (10.9% vs. 2.9%, P < 0.05). Moreover, D6 blastocysts had considerably slower developmental kinetics and poorer blastocyst morphologies. Further analysis confirmed that the LB rate was not associated with developmental kinetics or dysmorphisms but rather with blastocyst morphology (inner cell mass [ICM] grade ≤ C vs. ICM grade A, adjusted OR = 0.155, 95% CI = 0.04–0.596, P < 0.05; trophectoderm [TE] grade ≤ C vs. TE grade A, adjusted OR = 0.157, 95% CI = 0.032–0.760, P < 0.05). In conclusion, D6 implanted blastocysts have a considerably lower LB rate than D5 implanted blastocysts. As determined by TL monitoring, the diminished blastocyst morphology can be one of the primary reasons underlying the decreased likelihood of LB.https://doi.org/10.1038/s41598-023-40052-5 |
| spellingShingle | Chien-Hong Chen Chun-I Lee Chun-Chia Huang Hsiu-Hui Chen Chih-Ying Chang En-Hui Cheng Pin-Yao Lin Chung-I Chen Tsung-Hsien Lee Maw-Sheng Lee Increased incidence of live births in implanted day 5 versus day 6 blastocysts following single embryo transfers with PGT-A Scientific Reports |
| title | Increased incidence of live births in implanted day 5 versus day 6 blastocysts following single embryo transfers with PGT-A |
| title_full | Increased incidence of live births in implanted day 5 versus day 6 blastocysts following single embryo transfers with PGT-A |
| title_fullStr | Increased incidence of live births in implanted day 5 versus day 6 blastocysts following single embryo transfers with PGT-A |
| title_full_unstemmed | Increased incidence of live births in implanted day 5 versus day 6 blastocysts following single embryo transfers with PGT-A |
| title_short | Increased incidence of live births in implanted day 5 versus day 6 blastocysts following single embryo transfers with PGT-A |
| title_sort | increased incidence of live births in implanted day 5 versus day 6 blastocysts following single embryo transfers with pgt a |
| url | https://doi.org/10.1038/s41598-023-40052-5 |
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