<i>Chrysanthemi Zawadskii</i> var. <i>Latilobum</i> Attenuates Obesity-Induced Skeletal Muscle Atrophy via Regulation of PRMTs in Skeletal Muscle of Mice
As obesity promotes ectopic fat accumulation in skeletal muscle, resulting in impaired skeletal muscle and mitochondria function, it is associated with skeletal muscle loss and dysfunction. This study investigated whether <i>Chrysanthemi zawadskii</i> var. <i>latilobum</i> (C...
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MDPI AG
2020-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/8/2811 |
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| author | Ahyoung Yoo Young Jin Jang Jiyun Ahn Chang Hwa Jung Hyo Deok Seo Tae Youl Ha |
| author_facet | Ahyoung Yoo Young Jin Jang Jiyun Ahn Chang Hwa Jung Hyo Deok Seo Tae Youl Ha |
| author_sort | Ahyoung Yoo |
| collection | DOAJ |
| description | As obesity promotes ectopic fat accumulation in skeletal muscle, resulting in impaired skeletal muscle and mitochondria function, it is associated with skeletal muscle loss and dysfunction. This study investigated whether <i>Chrysanthemi zawadskii</i> var. <i>latilobum</i> (CZH) protected mice against obesity-induced skeletal muscle atrophy and the underlying molecular mechanisms. High-fat diet (HFD)-induced obese mice were orally administered either distilled water, low-dose CZH (125 mg/kg), or high-dose CZH (250 mg/kg) for 8 w. CZH reduced obesity-induced increases in inflammatory cytokines levels and skeletal muscle atrophy, which is induced by expression of atrophic genes such as muscle RING-finger protein 1 and muscle atrophy F-box. CZH also improved muscle function according to treadmill running results and increased the muscle fiber size in skeletal muscle. Furthermore, CZH upregulated mRNA and protein levels of protein arginine methyltransferases (PRMT)1 and PRMT7, which subsequently attenuated mitochondrial dysfunction in the skeletal muscle of obese mice. We also observed that CZH significantly decreased PRMT6 mRNA and protein expression, which resulted in decreased muscle atrophy. These results suggest that CZH ameliorated obesity-induced skeletal muscle atrophy in mice via regulation of PRMTs in skeletal muscle. |
| first_indexed | 2024-03-10T20:23:51Z |
| format | Article |
| id | doaj.art-13d6566d94a94aafb179c04fb54f0de5 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T20:23:51Z |
| publishDate | 2020-04-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-13d6566d94a94aafb179c04fb54f0de52023-11-19T21:56:54ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-04-01218281110.3390/ijms21082811<i>Chrysanthemi Zawadskii</i> var. <i>Latilobum</i> Attenuates Obesity-Induced Skeletal Muscle Atrophy via Regulation of PRMTs in Skeletal Muscle of MiceAhyoung Yoo0Young Jin Jang1Jiyun Ahn2Chang Hwa Jung3Hyo Deok Seo4Tae Youl Ha5Division of Food Functionality Research, Korea Food Research Institute, Wanju-gun 55365, KoreaDivision of Food Functionality Research, Korea Food Research Institute, Wanju-gun 55365, KoreaDivision of Food Functionality Research, Korea Food Research Institute, Wanju-gun 55365, KoreaDivision of Food Functionality Research, Korea Food Research Institute, Wanju-gun 55365, KoreaDivision of Food Functionality Research, Korea Food Research Institute, Wanju-gun 55365, KoreaDivision of Food Functionality Research, Korea Food Research Institute, Wanju-gun 55365, KoreaAs obesity promotes ectopic fat accumulation in skeletal muscle, resulting in impaired skeletal muscle and mitochondria function, it is associated with skeletal muscle loss and dysfunction. This study investigated whether <i>Chrysanthemi zawadskii</i> var. <i>latilobum</i> (CZH) protected mice against obesity-induced skeletal muscle atrophy and the underlying molecular mechanisms. High-fat diet (HFD)-induced obese mice were orally administered either distilled water, low-dose CZH (125 mg/kg), or high-dose CZH (250 mg/kg) for 8 w. CZH reduced obesity-induced increases in inflammatory cytokines levels and skeletal muscle atrophy, which is induced by expression of atrophic genes such as muscle RING-finger protein 1 and muscle atrophy F-box. CZH also improved muscle function according to treadmill running results and increased the muscle fiber size in skeletal muscle. Furthermore, CZH upregulated mRNA and protein levels of protein arginine methyltransferases (PRMT)1 and PRMT7, which subsequently attenuated mitochondrial dysfunction in the skeletal muscle of obese mice. We also observed that CZH significantly decreased PRMT6 mRNA and protein expression, which resulted in decreased muscle atrophy. These results suggest that CZH ameliorated obesity-induced skeletal muscle atrophy in mice via regulation of PRMTs in skeletal muscle.https://www.mdpi.com/1422-0067/21/8/2811<i>Chrysanthemi zawadskii</i> var. <i>latilobum</i>obesity-induced skeletal muscle atrophyPRMTsmitochondrial function |
| spellingShingle | Ahyoung Yoo Young Jin Jang Jiyun Ahn Chang Hwa Jung Hyo Deok Seo Tae Youl Ha <i>Chrysanthemi Zawadskii</i> var. <i>Latilobum</i> Attenuates Obesity-Induced Skeletal Muscle Atrophy via Regulation of PRMTs in Skeletal Muscle of Mice International Journal of Molecular Sciences <i>Chrysanthemi zawadskii</i> var. <i>latilobum</i> obesity-induced skeletal muscle atrophy PRMTs mitochondrial function |
| title | <i>Chrysanthemi Zawadskii</i> var. <i>Latilobum</i> Attenuates Obesity-Induced Skeletal Muscle Atrophy via Regulation of PRMTs in Skeletal Muscle of Mice |
| title_full | <i>Chrysanthemi Zawadskii</i> var. <i>Latilobum</i> Attenuates Obesity-Induced Skeletal Muscle Atrophy via Regulation of PRMTs in Skeletal Muscle of Mice |
| title_fullStr | <i>Chrysanthemi Zawadskii</i> var. <i>Latilobum</i> Attenuates Obesity-Induced Skeletal Muscle Atrophy via Regulation of PRMTs in Skeletal Muscle of Mice |
| title_full_unstemmed | <i>Chrysanthemi Zawadskii</i> var. <i>Latilobum</i> Attenuates Obesity-Induced Skeletal Muscle Atrophy via Regulation of PRMTs in Skeletal Muscle of Mice |
| title_short | <i>Chrysanthemi Zawadskii</i> var. <i>Latilobum</i> Attenuates Obesity-Induced Skeletal Muscle Atrophy via Regulation of PRMTs in Skeletal Muscle of Mice |
| title_sort | i chrysanthemi zawadskii i var i latilobum i attenuates obesity induced skeletal muscle atrophy via regulation of prmts in skeletal muscle of mice |
| topic | <i>Chrysanthemi zawadskii</i> var. <i>latilobum</i> obesity-induced skeletal muscle atrophy PRMTs mitochondrial function |
| url | https://www.mdpi.com/1422-0067/21/8/2811 |
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