Clinical, Laboratory, and Radiological Findings in Acute Necrotising Encephalopathy of Childhood: A Case Series
Acute Necrotising Encephalopathy of Childhood (ANEC) is a fatal disease diagnosed on basis of clinical and typical Magnetic Resonance Imaging (MRI) findings. The prognosis of this encephalopathy is generally poor, with fewer than 10% of cases recovering completely. Patients with a favourable outco...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2023-10-01
|
| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://www.jcdr.net/articles/PDF/18529/65063_CE[Ra1]_F(SS)_QC(AN_IS)_PF1(AKA_KM)_PFA(AKA_KM)_PN(KM).pdf |
| _version_ | 1797652978985861120 |
|---|---|
| author | RN KARTHIK K VIDYA K PUSHPALATHA S LAVANYA |
| author_facet | RN KARTHIK K VIDYA K PUSHPALATHA S LAVANYA |
| author_sort | RN KARTHIK |
| collection | DOAJ |
| description | Acute Necrotising Encephalopathy of Childhood (ANEC) is a fatal disease diagnosed on basis of clinical and typical Magnetic Resonance
Imaging (MRI) findings. The prognosis of this encephalopathy is generally poor, with fewer than 10% of cases recovering completely.
Patients with a favourable outcome had reversible neuroimaging findings. Long-term sequelae commonly include neurologic deficits
such as spasticity, epilepsy, and involuntary movements. In this case series, five cases of ANEC were reported. The children included
in this series ranged in age from nine months to 16 years. All the children were female, and their presenting symptoms included
seizures (n=5), altered sensorium (n=5), features of raised intracranial pressure (n=5), and posturing (n=1). Neuroimaging revealed
characteristic lesions in the thalamus with varied involvement of other parts of the brain in all cases (n=5). Cerebrospinal Fluid
(CSF) analysis was normal in the majority of children. Four out of five cases survived and responded to early steroids, intravenous
immunoglobulin, physiotherapy, and rehabilitation. One child had complete recovery, with three children experiencing disabilities and
one child succumbing to the disease. |
| first_indexed | 2024-03-11T16:37:46Z |
| format | Article |
| id | doaj.art-13d8b9e6dc6e417f92bf45d48e65a2e9 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-03-11T16:37:46Z |
| publishDate | 2023-10-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-13d8b9e6dc6e417f92bf45d48e65a2e92023-10-23T10:28:52ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2023-10-011710050810.7860/JCDR/2023/65063.18529Clinical, Laboratory, and Radiological Findings in Acute Necrotising Encephalopathy of Childhood: A Case SeriesRN KARTHIK0K VIDYA1K PUSHPALATHA2S LAVANYA3Senior Resident, Department of Paediatrics, ESICMC and PGIMSR, Bangalore, Karnataka, India.PICU Intensivist, Department of Paediatrics, ESICMC and PGIMSR, Bangalore, Karnataka, India.Professor and Head, Department of Paediatrics, ESICMC and PGIMSR, Bangalore, Karnataka, India.Assistant Professor, Department of Paediatrics, ESICMC and PGIMSR, Bangalore, Karnataka, India.Acute Necrotising Encephalopathy of Childhood (ANEC) is a fatal disease diagnosed on basis of clinical and typical Magnetic Resonance Imaging (MRI) findings. The prognosis of this encephalopathy is generally poor, with fewer than 10% of cases recovering completely. Patients with a favourable outcome had reversible neuroimaging findings. Long-term sequelae commonly include neurologic deficits such as spasticity, epilepsy, and involuntary movements. In this case series, five cases of ANEC were reported. The children included in this series ranged in age from nine months to 16 years. All the children were female, and their presenting symptoms included seizures (n=5), altered sensorium (n=5), features of raised intracranial pressure (n=5), and posturing (n=1). Neuroimaging revealed characteristic lesions in the thalamus with varied involvement of other parts of the brain in all cases (n=5). Cerebrospinal Fluid (CSF) analysis was normal in the majority of children. Four out of five cases survived and responded to early steroids, intravenous immunoglobulin, physiotherapy, and rehabilitation. One child had complete recovery, with three children experiencing disabilities and one child succumbing to the disease.https://www.jcdr.net/articles/PDF/18529/65063_CE[Ra1]_F(SS)_QC(AN_IS)_PF1(AKA_KM)_PFA(AKA_KM)_PN(KM).pdfintravenous immunoglobulinthalamic lesionsspasticity |
| spellingShingle | RN KARTHIK K VIDYA K PUSHPALATHA S LAVANYA Clinical, Laboratory, and Radiological Findings in Acute Necrotising Encephalopathy of Childhood: A Case Series Journal of Clinical and Diagnostic Research intravenous immunoglobulin thalamic lesions spasticity |
| title | Clinical, Laboratory, and Radiological Findings in Acute Necrotising Encephalopathy of Childhood: A Case Series |
| title_full | Clinical, Laboratory, and Radiological Findings in Acute Necrotising Encephalopathy of Childhood: A Case Series |
| title_fullStr | Clinical, Laboratory, and Radiological Findings in Acute Necrotising Encephalopathy of Childhood: A Case Series |
| title_full_unstemmed | Clinical, Laboratory, and Radiological Findings in Acute Necrotising Encephalopathy of Childhood: A Case Series |
| title_short | Clinical, Laboratory, and Radiological Findings in Acute Necrotising Encephalopathy of Childhood: A Case Series |
| title_sort | clinical laboratory and radiological findings in acute necrotising encephalopathy of childhood a case series |
| topic | intravenous immunoglobulin thalamic lesions spasticity |
| url | https://www.jcdr.net/articles/PDF/18529/65063_CE[Ra1]_F(SS)_QC(AN_IS)_PF1(AKA_KM)_PFA(AKA_KM)_PN(KM).pdf |
| work_keys_str_mv | AT rnkarthik clinicallaboratoryandradiologicalfindingsinacutenecrotisingencephalopathyofchildhoodacaseseries AT kvidya clinicallaboratoryandradiologicalfindingsinacutenecrotisingencephalopathyofchildhoodacaseseries AT kpushpalatha clinicallaboratoryandradiologicalfindingsinacutenecrotisingencephalopathyofchildhoodacaseseries AT slavanya clinicallaboratoryandradiologicalfindingsinacutenecrotisingencephalopathyofchildhoodacaseseries |