Inhibition of STAT3 phosphorylation attenuates impairments in learning and memory in 5XFAD mice, an animal model of Alzheimer's disease

Inhibition of STAT3 phosphorylation attenuates impairments in learning and memory in 5XFAD mice, an animal model of Alzheimer's disease

The pathophysiological roles of astrocytes in the reactive state are thought to have important significance in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD). However, the detailed mechanisms underlying the transition of astrocytes from the resting state to t...

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Bibliographic Details
Main Authors: Moonseok Choi, Hyunju Kim, Eun-Jeong Yang, Hye-Sun Kim
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Journal of Pharmacological Sciences
Subjects:
Astrocyte
JAK / STAT3
Memory
Alzheimer's disease
5XFAD mice
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861320300530

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