Autoimmune epilepsy
Investigation of autoimmune epilepsy (AIE) has been attracting increasingly more attention due to discovery of neuronal antibodies and improved understanding of the mechanisms related to such immune-mediated syndromes. The review is aimed at autoimmune epilepsy taking into account up-to-date advance...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2022-04-01
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| Series: | Эпилепсия и пароксизмальные состояния |
| Subjects: | |
| Online Access: | https://www.epilepsia.su/jour/article/view/777 |
| _version_ | 1797879352556257280 |
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| author | О. S. Shilkina E. A. Kantimirova A. A. Usoltseva Т. I. Prusova D. V. Dmitrenko |
| author_facet | О. S. Shilkina E. A. Kantimirova A. A. Usoltseva Т. I. Prusova D. V. Dmitrenko |
| author_sort | О. S. Shilkina |
| collection | DOAJ |
| description | Investigation of autoimmune epilepsy (AIE) has been attracting increasingly more attention due to discovery of neuronal antibodies and improved understanding of the mechanisms related to such immune-mediated syndromes. The review is aimed at autoimmune epilepsy taking into account up-to-date advances in exploring its pathophysiology. Definitions related to this issue are outlined, and pathogenetic mechanisms, features of antineuronal antibodies as well as AIE clinical picture based on type of autoantibodies, are considered. The necessity of regular monitoring patients with AIE is indicated, preferably by an epileptologist together with a neuroimmunologist. With prolonged follow-up, chronic pharmacoresistant epilepsy persists in some patients, despite aggressive immunotherapy and antiepileptic drugs. With a deeper understanding of the mechanisms of antibody-mediated and autoantigen-specific T-cell-mediated AIE syndromes, the use of antiepileptic drugs and immunotherapy can be further optimized. |
| first_indexed | 2024-04-10T02:46:21Z |
| format | Article |
| id | doaj.art-13d94ab2d12347e78df2c169074adfc2 |
| institution | Directory Open Access Journal |
| issn | 2077-8333 2311-4088 |
| language | Russian |
| last_indexed | 2024-04-10T02:46:21Z |
| publishDate | 2022-04-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Эпилепсия и пароксизмальные состояния |
| spelling | doaj.art-13d94ab2d12347e78df2c169074adfc22023-03-13T07:44:18ZrusIRBIS LLCЭпилепсия и пароксизмальные состояния2077-83332311-40882022-04-01141749010.17749/2077-8333/epi.par.con.2022.108574Autoimmune epilepsyО. S. Shilkina0E. A. Kantimirova1A. A. Usoltseva2Т. I. Prusova3D. V. Dmitrenko4Neurological Center of Epileptology, Neurogenetics and Brain ResearchVoino-Yasenetsky Krasnoyarsk State Medical UniversityVoino-Yasenetsky Krasnoyarsk State Medical UniversityVoino-Yasenetsky Krasnoyarsk State Medical UniversityVoino-Yasenetsky Krasnoyarsk State Medical UniversityInvestigation of autoimmune epilepsy (AIE) has been attracting increasingly more attention due to discovery of neuronal antibodies and improved understanding of the mechanisms related to such immune-mediated syndromes. The review is aimed at autoimmune epilepsy taking into account up-to-date advances in exploring its pathophysiology. Definitions related to this issue are outlined, and pathogenetic mechanisms, features of antineuronal antibodies as well as AIE clinical picture based on type of autoantibodies, are considered. The necessity of regular monitoring patients with AIE is indicated, preferably by an epileptologist together with a neuroimmunologist. With prolonged follow-up, chronic pharmacoresistant epilepsy persists in some patients, despite aggressive immunotherapy and antiepileptic drugs. With a deeper understanding of the mechanisms of antibody-mediated and autoantigen-specific T-cell-mediated AIE syndromes, the use of antiepileptic drugs and immunotherapy can be further optimized.https://www.epilepsia.su/jour/article/view/777autoimmune epilepsydefinitionpathophysiologyantineuronal antibodiesclinical picture |
| spellingShingle | О. S. Shilkina E. A. Kantimirova A. A. Usoltseva Т. I. Prusova D. V. Dmitrenko Autoimmune epilepsy Эпилепсия и пароксизмальные состояния autoimmune epilepsy definition pathophysiology antineuronal antibodies clinical picture |
| title | Autoimmune epilepsy |
| title_full | Autoimmune epilepsy |
| title_fullStr | Autoimmune epilepsy |
| title_full_unstemmed | Autoimmune epilepsy |
| title_short | Autoimmune epilepsy |
| title_sort | autoimmune epilepsy |
| topic | autoimmune epilepsy definition pathophysiology antineuronal antibodies clinical picture |
| url | https://www.epilepsia.su/jour/article/view/777 |
| work_keys_str_mv | AT osshilkina autoimmuneepilepsy AT eakantimirova autoimmuneepilepsy AT aausoltseva autoimmuneepilepsy AT tiprusova autoimmuneepilepsy AT dvdmitrenko autoimmuneepilepsy |