Lower circulating preptin levels in male patients with osteoporosis are correlated with bone mineral density and bone formation
<p>Abstract</p> <p>Background</p> <p>Serum preptin levels among subjects with different bone mineral densities (BMD) were measured and investigated to determine the correlation between BMD and bone-metabolic markers.</p> <p>Methods</p> <p>Approxi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2013-01-01
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| Series: | BMC Musculoskeletal Disorders |
| Subjects: | |
| Online Access: | http://www.biomedcentral.com/1471-2474/14/49 |
| _version_ | 1811311272772239360 |
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| author | Li Ning Zheng Yi-Bo Han Jie Liang Wei Wang Jia-Yi Zhou Jie-Ru Shen Yi Zhang Jie |
| author_facet | Li Ning Zheng Yi-Bo Han Jie Liang Wei Wang Jia-Yi Zhou Jie-Ru Shen Yi Zhang Jie |
| author_sort | Li Ning |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Serum preptin levels among subjects with different bone mineral densities (BMD) were measured and investigated to determine the correlation between BMD and bone-metabolic markers.</p> <p>Methods</p> <p>Approximately 52 elderly male patients with osteoporosis, 50 elderly men with osteopaenia, and 31 age-matched normal bone mass controls participated in the study. The serum preptin levels and bone metabolic markers were measured by enzyme-linked immunosorbent assay. The relationships between preptin levels, BMD, and metabolic parameters were also assessed.</p> <p>Results</p> <p>The serum preptin level was the lowest in the osteoporosis group and positively correlated with BMD. All the bone formation markers in the osteoporosis and osteopaenia groups were significantly reduced compared with those in the normal group. Serum preptin level was positively correlated with all the bone formation markers, whereas no correlation was observed with the bone resorption marker TRACP-5b.</p> <p>Conclusions</p> <p>Serum preptin levels are decreased in osteoporosis and osteopaenia patients and positively correlated with BMD. Therefore, preptin is involved in the pathogenesis of osteoporosis, probably through bone formation rather than bone resorption.</p> |
| first_indexed | 2024-04-13T10:14:53Z |
| format | Article |
| id | doaj.art-13d985a0b07c405680223a339b0133b9 |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-04-13T10:14:53Z |
| publishDate | 2013-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-13d985a0b07c405680223a339b0133b92022-12-22T02:50:45ZengBMCBMC Musculoskeletal Disorders1471-24742013-01-011414910.1186/1471-2474-14-49Lower circulating preptin levels in male patients with osteoporosis are correlated with bone mineral density and bone formationLi NingZheng Yi-BoHan JieLiang WeiWang Jia-YiZhou Jie-RuShen YiZhang Jie<p>Abstract</p> <p>Background</p> <p>Serum preptin levels among subjects with different bone mineral densities (BMD) were measured and investigated to determine the correlation between BMD and bone-metabolic markers.</p> <p>Methods</p> <p>Approximately 52 elderly male patients with osteoporosis, 50 elderly men with osteopaenia, and 31 age-matched normal bone mass controls participated in the study. The serum preptin levels and bone metabolic markers were measured by enzyme-linked immunosorbent assay. The relationships between preptin levels, BMD, and metabolic parameters were also assessed.</p> <p>Results</p> <p>The serum preptin level was the lowest in the osteoporosis group and positively correlated with BMD. All the bone formation markers in the osteoporosis and osteopaenia groups were significantly reduced compared with those in the normal group. Serum preptin level was positively correlated with all the bone formation markers, whereas no correlation was observed with the bone resorption marker TRACP-5b.</p> <p>Conclusions</p> <p>Serum preptin levels are decreased in osteoporosis and osteopaenia patients and positively correlated with BMD. Therefore, preptin is involved in the pathogenesis of osteoporosis, probably through bone formation rather than bone resorption.</p>http://www.biomedcentral.com/1471-2474/14/49PreptinOsteoporosisBone densityBone metabolic marker |
| spellingShingle | Li Ning Zheng Yi-Bo Han Jie Liang Wei Wang Jia-Yi Zhou Jie-Ru Shen Yi Zhang Jie Lower circulating preptin levels in male patients with osteoporosis are correlated with bone mineral density and bone formation BMC Musculoskeletal Disorders Preptin Osteoporosis Bone density Bone metabolic marker |
| title | Lower circulating preptin levels in male patients with osteoporosis are correlated with bone mineral density and bone formation |
| title_full | Lower circulating preptin levels in male patients with osteoporosis are correlated with bone mineral density and bone formation |
| title_fullStr | Lower circulating preptin levels in male patients with osteoporosis are correlated with bone mineral density and bone formation |
| title_full_unstemmed | Lower circulating preptin levels in male patients with osteoporosis are correlated with bone mineral density and bone formation |
| title_short | Lower circulating preptin levels in male patients with osteoporosis are correlated with bone mineral density and bone formation |
| title_sort | lower circulating preptin levels in male patients with osteoporosis are correlated with bone mineral density and bone formation |
| topic | Preptin Osteoporosis Bone density Bone metabolic marker |
| url | http://www.biomedcentral.com/1471-2474/14/49 |
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