Occult polyclonality of preclinical pancreatic cancer models drives in vitro evolution

Occult polyclonality of preclinical pancreatic cancer models drives in vitro evolution

It is unclear if the molecular profiles of pancreatic ductal adenocarcinoma (PDAC) preclinical models remain stable during propagation. Here, the authors characterise clonal evolution throughout propagation in PDAC cell lines and a patient-derived organoid using single-cell genomics, transcriptomics...

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Bibliographic Details
Main Authors: Maria E. Monberg, Heather Geiger, Jaewon J. Lee, Roshan Sharma, Alexander Semaan, Vincent Bernard, Justin Wong, Fang Wang, Shaoheng Liang, Daniel B. Swartzlander, Bret M. Stephens, Matthew H. G. Katz, Ken Chen, Nicolas Robine, Paola A. Guerrero, Anirban Maitra
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-31376-3

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