Does the addition of metformin to carboplatin treatment decreases ovarian reserve damage associated with carboplatin usage?

Does the addition of metformin to carboplatin treatment decreases ovarian reserve damage associated with carboplatin usage?

Abstract Background We aimed to determine whether adding metformin to carboplatin treatment would reduce the damage to ovarian reserve associated with carboplatin use. Methods We included 35 adult female non-pregnant albino Wistar rats approximately three months old, weighing 220–310 g. The rats wer...

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Bibliographic Details
Main Authors: Sevgi Ayhan, Necati Hancerliogullari, Gurhan Guney, Murat Gozukucuk, Muzaffer Caydere, Sergul Selvi Guney, Aytekin Tokmak, Yusuf Ustun
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Journal of Ovarian Research
Subjects:
Antioxidant
Catalase
Malondialdehyde
Metformin
Carboplatin
Ovarian cancer
Online Access:https://doi.org/10.1186/s13048-023-01259-2

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