Early Vascular and Functional Changes after Vitreoretinal Surgery: A Comparison between the Macular Hole and Epiretinal Membrane
(1) Background: The aim of this observational comparative study was to investigate early retinal vascular and functional changes in patients undergoing vitreoretinal surgery for idiopathic epiretinal membrane (iERM) or macular hole (MH) using a widefield swept-source optical coherence tomography ang...
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| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/6/1031 |
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| author | Rossella D’Aloisio Paolo Carpineto Agbéanda Aharrh-Gnama Carla Iafigliola Luca Cerino Marta Di Nicola Annamaria Porreca Lisa Toto Rodolfo Mastropasqua |
| author_facet | Rossella D’Aloisio Paolo Carpineto Agbéanda Aharrh-Gnama Carla Iafigliola Luca Cerino Marta Di Nicola Annamaria Porreca Lisa Toto Rodolfo Mastropasqua |
| author_sort | Rossella D’Aloisio |
| collection | DOAJ |
| description | (1) Background: The aim of this observational comparative study was to investigate early retinal vascular and functional changes in patients undergoing vitreoretinal surgery for idiopathic epiretinal membrane (iERM) or macular hole (MH) using a widefield swept-source optical coherence tomography angiography (WSS-OCTA). (2) Methods: Forty one diseased eyes were enrolled in the study. Twenty three eyes with iERM diagnosis (ERM group) underwent 25-gauge vitrectomy with inner limiting membrane (ILM) and MER peeling, while eighteen eyes with MH (MH group) underwent 25-gauge vitrectomy with inverted flap technique. Functional and anatomical/perfusion parameters were evaluated pre- and postoperatively in all eyes by means of WSS-OCTA system, microperimetry (MP3), best corrected visual acuity assessment, central macular thickness (CMT) and MH diameter calculation. For each eye, 12 × 12 mm OCTA volume scans were acquired by a retinal specialist and a semi-automated algorithm was used for a quantitative vessel analysis of the superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris (CC). In detail, perfusion density (PD) of the SCP, DCP and CC was evaluated in four circles (one central in the macular area of 5 mm diameter; three midperiphery circles (temporal, superior and inferior) of 3 mm). In addition, the vessel length density (VLD) of the SCP and DCP for the same circles was quantified. (3) Results: In the MH group, PD of the SCP significantly increased in the macular area (<i>p</i> = 0.018) and in the superior ring (<i>p</i> = 0.016); PD of the DCP significantly increased in the macular area (<i>p</i> = 0.015) and in the superior and inferior ring (<i>p</i> = 0.016) 3 months after surgery. In the ERM group, PD of the SCP and DCP significantly increased in the macular area and superior ring, respectively (<i>p</i> = 0.001; <i>p</i> = 0.032), 3 months after surgery. During follow-up there was a significant improvement in terms of functional (Best corrected visual acuity, <i>p</i> = 0.007 and <i>p</i> = 0.029; microperimetry ((MP3) 10°, <i>p</i> = 0.003 and <i>p</i> = 0.004; MP3 2°, <i>p</i> = 0.028 and <i>p</i> = 0.003 in MH group and ERM group respectively) and anatomical parameters (CMT, <i>p</i> = 0.049 in ERM group; hole complete closure in MH group). (4) Conclusions: After vitreoretinal surgery, early retinal vascular and functional changes can be promptly observed and quantified to monitor and potentially predict surgery outcomes. Widefield OCTA devices allow for a detailed microvasculature analysis of retina and choriocapillaris in the macular area and in the periphery, showing a different behaviour of retinal sectors in two distinct vitreoretinal disorders. |
| first_indexed | 2024-03-10T10:43:35Z |
| format | Article |
| id | doaj.art-13de95e18d2548c0a4ad875433b16d0b |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T10:43:35Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-13de95e18d2548c0a4ad875433b16d0b2023-11-21T22:44:19ZengMDPI AGDiagnostics2075-44182021-06-01116103110.3390/diagnostics11061031Early Vascular and Functional Changes after Vitreoretinal Surgery: A Comparison between the Macular Hole and Epiretinal MembraneRossella D’Aloisio0Paolo Carpineto1Agbéanda Aharrh-Gnama2Carla Iafigliola3Luca Cerino4Marta Di Nicola5Annamaria Porreca6Lisa Toto7Rodolfo Mastropasqua8Ophthalmology Clinic, Department of Medicine and Science of Ageing, University “G. d’Annunzio” Chieti-Pescara, via dei Vestini 31, 66100 Chieti, ItalyOphthalmology Clinic, Department of Medicine and Science of Ageing, University “G. d’Annunzio” Chieti-Pescara, via dei Vestini 31, 66100 Chieti, ItalyOphthalmology Clinic, Department of Medicine and Science of Ageing, University “G. d’Annunzio” Chieti-Pescara, via dei Vestini 31, 66100 Chieti, ItalyOphthalmology Clinic, Department of Medicine and Science of Ageing, University “G. d’Annunzio” Chieti-Pescara, via dei Vestini 31, 66100 Chieti, ItalyOphthalmology Clinic, Department of Medicine and Science of Ageing, University “G. d’Annunzio” Chieti-Pescara, via dei Vestini 31, 66100 Chieti, ItalyLaboratory of Biostatistics, Department of Medical, Oral and Biotechnological Sciences, University “G. d’Annunzio” Chieti-Pescara, via dei Vestini 31, 66100 Chieti, ItalyDepartment of Economic Studies, University “G. d’Annunzio” Chieti-Pescara, Viale Pindaro, 65100 Pescara, ItalyOphthalmology Clinic, Department of Medicine and Science of Ageing, University “G. d’Annunzio” Chieti-Pescara, via dei Vestini 31, 66100 Chieti, ItalyInstitute of Ophthalmology, University of Modena and Reggio Emilia, 41121 Modena, Italy(1) Background: The aim of this observational comparative study was to investigate early retinal vascular and functional changes in patients undergoing vitreoretinal surgery for idiopathic epiretinal membrane (iERM) or macular hole (MH) using a widefield swept-source optical coherence tomography angiography (WSS-OCTA). (2) Methods: Forty one diseased eyes were enrolled in the study. Twenty three eyes with iERM diagnosis (ERM group) underwent 25-gauge vitrectomy with inner limiting membrane (ILM) and MER peeling, while eighteen eyes with MH (MH group) underwent 25-gauge vitrectomy with inverted flap technique. Functional and anatomical/perfusion parameters were evaluated pre- and postoperatively in all eyes by means of WSS-OCTA system, microperimetry (MP3), best corrected visual acuity assessment, central macular thickness (CMT) and MH diameter calculation. For each eye, 12 × 12 mm OCTA volume scans were acquired by a retinal specialist and a semi-automated algorithm was used for a quantitative vessel analysis of the superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris (CC). In detail, perfusion density (PD) of the SCP, DCP and CC was evaluated in four circles (one central in the macular area of 5 mm diameter; three midperiphery circles (temporal, superior and inferior) of 3 mm). In addition, the vessel length density (VLD) of the SCP and DCP for the same circles was quantified. (3) Results: In the MH group, PD of the SCP significantly increased in the macular area (<i>p</i> = 0.018) and in the superior ring (<i>p</i> = 0.016); PD of the DCP significantly increased in the macular area (<i>p</i> = 0.015) and in the superior and inferior ring (<i>p</i> = 0.016) 3 months after surgery. In the ERM group, PD of the SCP and DCP significantly increased in the macular area and superior ring, respectively (<i>p</i> = 0.001; <i>p</i> = 0.032), 3 months after surgery. During follow-up there was a significant improvement in terms of functional (Best corrected visual acuity, <i>p</i> = 0.007 and <i>p</i> = 0.029; microperimetry ((MP3) 10°, <i>p</i> = 0.003 and <i>p</i> = 0.004; MP3 2°, <i>p</i> = 0.028 and <i>p</i> = 0.003 in MH group and ERM group respectively) and anatomical parameters (CMT, <i>p</i> = 0.049 in ERM group; hole complete closure in MH group). (4) Conclusions: After vitreoretinal surgery, early retinal vascular and functional changes can be promptly observed and quantified to monitor and potentially predict surgery outcomes. Widefield OCTA devices allow for a detailed microvasculature analysis of retina and choriocapillaris in the macular area and in the periphery, showing a different behaviour of retinal sectors in two distinct vitreoretinal disorders.https://www.mdpi.com/2075-4418/11/6/1031widefield swept-source optical coherence tomography angiographyvitreoretinal surgerymacular holeepiretinal membrane |
| spellingShingle | Rossella D’Aloisio Paolo Carpineto Agbéanda Aharrh-Gnama Carla Iafigliola Luca Cerino Marta Di Nicola Annamaria Porreca Lisa Toto Rodolfo Mastropasqua Early Vascular and Functional Changes after Vitreoretinal Surgery: A Comparison between the Macular Hole and Epiretinal Membrane Diagnostics widefield swept-source optical coherence tomography angiography vitreoretinal surgery macular hole epiretinal membrane |
| title | Early Vascular and Functional Changes after Vitreoretinal Surgery: A Comparison between the Macular Hole and Epiretinal Membrane |
| title_full | Early Vascular and Functional Changes after Vitreoretinal Surgery: A Comparison between the Macular Hole and Epiretinal Membrane |
| title_fullStr | Early Vascular and Functional Changes after Vitreoretinal Surgery: A Comparison between the Macular Hole and Epiretinal Membrane |
| title_full_unstemmed | Early Vascular and Functional Changes after Vitreoretinal Surgery: A Comparison between the Macular Hole and Epiretinal Membrane |
| title_short | Early Vascular and Functional Changes after Vitreoretinal Surgery: A Comparison between the Macular Hole and Epiretinal Membrane |
| title_sort | early vascular and functional changes after vitreoretinal surgery a comparison between the macular hole and epiretinal membrane |
| topic | widefield swept-source optical coherence tomography angiography vitreoretinal surgery macular hole epiretinal membrane |
| url | https://www.mdpi.com/2075-4418/11/6/1031 |
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