Prolonged Endurance Exercise Adaptations Counteract Doxorubicin Chemotherapy-Induced Myotoxicity in Mice

Prolonged Endurance Exercise Adaptations Counteract Doxorubicin Chemotherapy-Induced Myotoxicity in Mice

Doxorubicin (DOX) is a potent chemotherapeutic agent widely used for various types of cancer; however, its accumulation causes myotoxicity and muscle atrophy. Endurance exercise (EXE) has emerged as a vaccine against DOX-induced myotoxicity. However, potential molecular mechanisms of EXE-mediated my...

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Bibliographic Details
Main Authors: Insu Kwon, Gwang-Woong Go, Youngil Lee, Jong-Hee Kim
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Applied Sciences
Subjects:
doxorubicin
chemotherapy
myotoxicity
endurance exercise
skeletal muscle
proteolytic system
Online Access:https://www.mdpi.com/2076-3417/12/7/3652

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