| Summary: | To systematically estimate the relevance between sperm parameters and serum
vitamin D levels and the subsequent reproductive outcomes in men. PubMed, Web of
Science and other databases were
searched for studies that examined a possible correlation between serum vitamin D
levels and sperm parameters and reproductive outcomes. The documents were
screened according to the corresponding inclusion and exclusion criteria.
Selection criteria included all published randomised and controlled trials and
non-randomised studies that focus on vitamin D and the reproductive function of
men The patients were classified into observation/intervention and control
groups, the intervention group was given vitamin D supplementation and the
control group was not. The meta-analysis was conducted using Stata 16.0 software.
A meta-analysis of 11 clinical studies that enrolled a total of 1356 patients,
revealed that the clinical pregnancy rate in the observation group was no
statistically different in the control group. A meta-analysis of 8 studies
demonstrated that there was no statistically difference in sperm concentration
between the experimental group and the control group. A meta-analysis of 8
studies found that sperm progressive motility in the experimental group was
greater than that in the control group by using a random-effects model. The mean
concentration of vitamin D was significantly lower in the control group.
Appropriate vitamin D supplement intervention in infertile men improves sperm
progressive motility. Interpretation of these results should be done with caution
due to the significant heterogeneity of the included studies. Furthermore,
Well-conducted prospective cohort studies are needed to better explain the
relationship between vitamin D and sperm parameters in infertile men.
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