Relationship between sleep disorders and the prognosis of neurological function after stroke
ObjectiveThis study aims to investigate the effects of sleep disorders on the prognosis of neurological function after stroke and other factors affecting the prognosis after stroke.MethodWe designed a cohort study. A total of 1,542 patients with their first stroke were hospitalized in the department...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.1036980/full |
| _version_ | 1811192309853716480 |
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| author | Yajing Zhang Xiaoshuang Xia Ting Zhang Chao Zhang Ran Liu Yun Yang Shuling Liu Xin Li Wei Yue |
| author_facet | Yajing Zhang Xiaoshuang Xia Ting Zhang Chao Zhang Ran Liu Yun Yang Shuling Liu Xin Li Wei Yue |
| author_sort | Yajing Zhang |
| collection | DOAJ |
| description | ObjectiveThis study aims to investigate the effects of sleep disorders on the prognosis of neurological function after stroke and other factors affecting the prognosis after stroke.MethodWe designed a cohort study. A total of 1,542 patients with their first stroke were hospitalized in the department of neurology of Tianjin Huanhu Hospital from 2015.6.1 to 2016.12.31. We recorded the personal histories of patients. The MMSE (mini-mental state examination), MoCA (Montreal Cognitive Assessment), HAMD (Hamilton Depression Scale), National Institutes of Health Stroke Scale (NIHSS) score, mRS (Modified Rankin Scale), BI (Barthel Index), PSQI (Pittsburgh Sleep Quality Index), ESS (Epworth Sleepiness Scale), Berlin questionnaire, and nocturnal TST (Total sleep time) were assessed before discharge, 3 months, 6 months, and 4 years (2019–2020) after stroke.ResultLow sleep quality (OR 2.019, 95%CI 1.199–3.398, p = 0.008), nocturnal TST (<7 h) (OR 4.060, 95%CI 1.494–11.034, p = 0.006), nocturnal TST (>8 h) (OR 5.928, 95% CI 2.134–16.464, p = 0.001) were risk factors for poor neurological function recovery at 3 months after stroke. Nocturnal TST (<7 h) (OR 13.042, 95%-CI 2.576–66.027, p = 0.002) and nocturnal TST (>8 h) (OR 11.559, 95%-CI 2.108–63.390, p = 0.005) were risk factors for poor neurological function at 6 months after stroke. Nocturnal TST (<7 h) (OR 2.668, 95% CI 1.250–5.698, p = 0.011) and nocturnal TST (>8 h) (OR 2.516, 95% CI 1.080–5.861, p = 0.033) were risk factors for poor neurological function at 4 years after stroke. High risk of OSA (HR 1.582, 95%CI 1.244–2.012, p < 0.001) was a risk factor for all-cause death in patients followed up for 4 years after stroke.ConclusionLow sleep quality is associated with short-term poor neurological function after stroke. Unusual nocturnal TST (long or short) is associated with short-term or long-term poor neurological function after stroke. A high risk of OSA is associated with a higher risk of all-cause death after stroke. |
| first_indexed | 2024-04-11T23:50:30Z |
| format | Article |
| id | doaj.art-13e479b661e549378fc687c17c1c4822 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-11T23:50:30Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-13e479b661e549378fc687c17c1c48222022-12-22T03:56:30ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-10-011310.3389/fneur.2022.10369801036980Relationship between sleep disorders and the prognosis of neurological function after strokeYajing Zhang0Xiaoshuang Xia1Ting Zhang2Chao Zhang3Ran Liu4Yun Yang5Shuling Liu6Xin Li7Wei Yue8Department of Neurology, Tianjin Huanhu Hospital, Tianjin, ChinaDepartment of Neurology, The Second Hospital of Tianjin Medical University, Tianjin, ChinaDepartment of Neurology, Tianjin Huanhu Hospital, Tianjin, ChinaDepartment of Neurology, Tianjin Huanhu Hospital, Tianjin, ChinaDepartment of Neurology, Tianjin Huanhu Hospital, Tianjin, ChinaDepartment of Neurology, Tianjin Huanhu Hospital, Tianjin, ChinaDepartment of Neurology, Tianjin Huanhu Hospital, Tianjin, ChinaDepartment of Neurology, The Second Hospital of Tianjin Medical University, Tianjin, ChinaDepartment of Neurology, Tianjin Huanhu Hospital, Tianjin, ChinaObjectiveThis study aims to investigate the effects of sleep disorders on the prognosis of neurological function after stroke and other factors affecting the prognosis after stroke.MethodWe designed a cohort study. A total of 1,542 patients with their first stroke were hospitalized in the department of neurology of Tianjin Huanhu Hospital from 2015.6.1 to 2016.12.31. We recorded the personal histories of patients. The MMSE (mini-mental state examination), MoCA (Montreal Cognitive Assessment), HAMD (Hamilton Depression Scale), National Institutes of Health Stroke Scale (NIHSS) score, mRS (Modified Rankin Scale), BI (Barthel Index), PSQI (Pittsburgh Sleep Quality Index), ESS (Epworth Sleepiness Scale), Berlin questionnaire, and nocturnal TST (Total sleep time) were assessed before discharge, 3 months, 6 months, and 4 years (2019–2020) after stroke.ResultLow sleep quality (OR 2.019, 95%CI 1.199–3.398, p = 0.008), nocturnal TST (<7 h) (OR 4.060, 95%CI 1.494–11.034, p = 0.006), nocturnal TST (>8 h) (OR 5.928, 95% CI 2.134–16.464, p = 0.001) were risk factors for poor neurological function recovery at 3 months after stroke. Nocturnal TST (<7 h) (OR 13.042, 95%-CI 2.576–66.027, p = 0.002) and nocturnal TST (>8 h) (OR 11.559, 95%-CI 2.108–63.390, p = 0.005) were risk factors for poor neurological function at 6 months after stroke. Nocturnal TST (<7 h) (OR 2.668, 95% CI 1.250–5.698, p = 0.011) and nocturnal TST (>8 h) (OR 2.516, 95% CI 1.080–5.861, p = 0.033) were risk factors for poor neurological function at 4 years after stroke. High risk of OSA (HR 1.582, 95%CI 1.244–2.012, p < 0.001) was a risk factor for all-cause death in patients followed up for 4 years after stroke.ConclusionLow sleep quality is associated with short-term poor neurological function after stroke. Unusual nocturnal TST (long or short) is associated with short-term or long-term poor neurological function after stroke. A high risk of OSA is associated with a higher risk of all-cause death after stroke.https://www.frontiersin.org/articles/10.3389/fneur.2022.1036980/fullsleep disordersneurological functionnocturnal total sleep timesleepinessOSA |
| spellingShingle | Yajing Zhang Xiaoshuang Xia Ting Zhang Chao Zhang Ran Liu Yun Yang Shuling Liu Xin Li Wei Yue Relationship between sleep disorders and the prognosis of neurological function after stroke Frontiers in Neurology sleep disorders neurological function nocturnal total sleep time sleepiness OSA |
| title | Relationship between sleep disorders and the prognosis of neurological function after stroke |
| title_full | Relationship between sleep disorders and the prognosis of neurological function after stroke |
| title_fullStr | Relationship between sleep disorders and the prognosis of neurological function after stroke |
| title_full_unstemmed | Relationship between sleep disorders and the prognosis of neurological function after stroke |
| title_short | Relationship between sleep disorders and the prognosis of neurological function after stroke |
| title_sort | relationship between sleep disorders and the prognosis of neurological function after stroke |
| topic | sleep disorders neurological function nocturnal total sleep time sleepiness OSA |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.1036980/full |
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