Body Mass Index Changes in Relation to Male Reproductive Hormones: Longitudinal Results From a Community-Based Cohort Study
The objective of the current study was to explore the relationship between longitudinal change in body mass index (BMI) and reproductive hormones in middle-aged and elderly Chinese men. A cohort study was conducted in a rural area of China. Local male residents aged 40–80 years were recruited at bas...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-09-01
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| Series: | American Journal of Men's Health |
| Online Access: | https://doi.org/10.1177/15579883211049044 |
| _version_ | 1818931091921174528 |
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| author | Yun Ye Qun-Feng Liang Jian-Hui Li Jun-Biao Zheng Xiao-Hua Yu Shu-Cheng Zhang Wei-Jin Zhou Hui-Juan Shi Guo-Qing Liang Qian-Xi Zhu |
| author_facet | Yun Ye Qun-Feng Liang Jian-Hui Li Jun-Biao Zheng Xiao-Hua Yu Shu-Cheng Zhang Wei-Jin Zhou Hui-Juan Shi Guo-Qing Liang Qian-Xi Zhu |
| author_sort | Yun Ye |
| collection | DOAJ |
| description | The objective of the current study was to explore the relationship between longitudinal change in body mass index (BMI) and reproductive hormones in middle-aged and elderly Chinese men. A cohort study was conducted in a rural area of China. Local male residents aged 40–80 years were recruited at baseline in 2012 and were followed up in 2016. Information about weight, height, waist circumference, sex hormones, smoking status, and medical history were obtained. The change in BMI reported no significant relationship with the change in total testosterone (TT), calculated free testosterone (cFT), and bioavailable testosterone (BioT) in Pearson correlation analyses. When the change in BMI was divided into three groups—“great loss,” “normal fluctuation,” and “great gain”—TT, cFT and BioT had the highest increase (or the lowest decrease) in men with “normal fluctuation” in BMI compared with the other two groups. The advantage of maintaining a stable BMI was more evident for those who were overweight, non-smoking, and disease-free. There was a tendency of a continuous increase in cFT and BioT with BMI increase in smoking and diseased populations. Maintaining a stable BMI is associated with maintaining normal levels of reproductive hormones, especially in overweight, non-smoking, and healthy men aged over 40 years. |
| first_indexed | 2024-12-20T04:11:05Z |
| format | Article |
| id | doaj.art-13e47efc158a4f10932b11cfcc894f5a |
| institution | Directory Open Access Journal |
| issn | 1557-9891 |
| language | English |
| last_indexed | 2024-12-20T04:11:05Z |
| publishDate | 2021-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | American Journal of Men's Health |
| spelling | doaj.art-13e47efc158a4f10932b11cfcc894f5a2022-12-21T19:53:55ZengSAGE PublishingAmerican Journal of Men's Health1557-98912021-09-011510.1177/15579883211049044Body Mass Index Changes in Relation to Male Reproductive Hormones: Longitudinal Results From a Community-Based Cohort StudyYun Ye0Qun-Feng Liang1Jian-Hui Li2Jun-Biao Zheng3Xiao-Hua Yu4Shu-Cheng Zhang5Wei-Jin Zhou6Hui-Juan Shi7Guo-Qing Liang8Qian-Xi Zhu9Department of Reproductive Epidemiology and Social Science, NHC Key Lab of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), Fudan University, Shanghai, ChinaRisk Adapted Prevention (RAD) Group, Division of Preventive Oncology, National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, GermanyDepartment of Reproductive Epidemiology and Social Science, NHC Key Lab of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), Fudan University, Shanghai, ChinaDepartment of Urology, The First People’s Hospital of Jiashan, Zhejiang, ChinaDepartment of Urology, The First People’s Hospital of Jiashan, Zhejiang, ChinaDepartment of Cell Biology, National Research Institute of Family Planning, Beijing, ChinaDepartment of Reproductive Epidemiology and Social Science, NHC Key Lab of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), Fudan University, Shanghai, ChinaDepartment of Reproductive Epidemiology and Social Science, NHC Key Lab of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), Fudan University, Shanghai, ChinaDepartment of Urology, Obstetrics and Gynecology hospital, Fudan University, Shanghai, ChinaDepartment of Reproductive Epidemiology and Social Science, NHC Key Lab of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), Fudan University, Shanghai, ChinaThe objective of the current study was to explore the relationship between longitudinal change in body mass index (BMI) and reproductive hormones in middle-aged and elderly Chinese men. A cohort study was conducted in a rural area of China. Local male residents aged 40–80 years were recruited at baseline in 2012 and were followed up in 2016. Information about weight, height, waist circumference, sex hormones, smoking status, and medical history were obtained. The change in BMI reported no significant relationship with the change in total testosterone (TT), calculated free testosterone (cFT), and bioavailable testosterone (BioT) in Pearson correlation analyses. When the change in BMI was divided into three groups—“great loss,” “normal fluctuation,” and “great gain”—TT, cFT and BioT had the highest increase (or the lowest decrease) in men with “normal fluctuation” in BMI compared with the other two groups. The advantage of maintaining a stable BMI was more evident for those who were overweight, non-smoking, and disease-free. There was a tendency of a continuous increase in cFT and BioT with BMI increase in smoking and diseased populations. Maintaining a stable BMI is associated with maintaining normal levels of reproductive hormones, especially in overweight, non-smoking, and healthy men aged over 40 years.https://doi.org/10.1177/15579883211049044 |
| spellingShingle | Yun Ye Qun-Feng Liang Jian-Hui Li Jun-Biao Zheng Xiao-Hua Yu Shu-Cheng Zhang Wei-Jin Zhou Hui-Juan Shi Guo-Qing Liang Qian-Xi Zhu Body Mass Index Changes in Relation to Male Reproductive Hormones: Longitudinal Results From a Community-Based Cohort Study American Journal of Men's Health |
| title | Body Mass Index Changes in Relation to Male Reproductive Hormones: Longitudinal Results From a Community-Based Cohort Study |
| title_full | Body Mass Index Changes in Relation to Male Reproductive Hormones: Longitudinal Results From a Community-Based Cohort Study |
| title_fullStr | Body Mass Index Changes in Relation to Male Reproductive Hormones: Longitudinal Results From a Community-Based Cohort Study |
| title_full_unstemmed | Body Mass Index Changes in Relation to Male Reproductive Hormones: Longitudinal Results From a Community-Based Cohort Study |
| title_short | Body Mass Index Changes in Relation to Male Reproductive Hormones: Longitudinal Results From a Community-Based Cohort Study |
| title_sort | body mass index changes in relation to male reproductive hormones longitudinal results from a community based cohort study |
| url | https://doi.org/10.1177/15579883211049044 |
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