Alkaloid ligands enable function of homomeric human α10 nicotinic acetylcholine receptors

Alkaloid ligands enable function of homomeric human α10 nicotinic acetylcholine receptors

In the nervous system, nicotinic acetylcholine receptors (nAChRs) rapidly transduce a chemical signal into one that is electrical via ligand-gated ion flux through the central channel of the receptor. However, some nAChR subunits are expressed by non-excitable cells where signal transduction apparen...

Full description

Bibliographic Details
Main Authors:	Arik J. Hone, J. Michael McIntosh
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-09-01
Series:	Frontiers in Pharmacology
Subjects:	α10 nicotinic acetylcholine receptors α-conotoxin RgIA strychnous nux vomica neuropathic pain chronic inflammation
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.981760/full

Similar Items

Nicotinic acetylcholine receptors: Therapeutic targets for novel ligands to treat pain and inflammation
by: Arik J. Hone, et al.
Published: (2023-04-01)

From Crystal Structures of RgIA4 in Complex with <i>Ac</i>-AChBP to Molecular Determinants of Its High Potency of α9α10 nAChR
by: Si Pan, et al.
Published: (2021-12-01)

<i>Conus regius</i>-Derived Conotoxins: Novel Therapeutic Opportunities from a Marine Organism
by: Francesco Margiotta, et al.
Published: (2022-12-01)

Crystal Structure of the Monomeric Extracellular Domain of α9 Nicotinic Receptor Subunit in Complex With α-Conotoxin RgIA: Molecular Dynamics Insights Into RgIA Binding to α9α10 Nicotinic Receptors
by: Marios Zouridakis, et al.
Published: (2019-05-01)

Corrigendum: Crystal structure of the monomeric extracellular domain of α9 nicotinic receptor subunit in complex with α-conotoxin RgIA: Molecular dynamics insights into RgIA binding to α9α10 nicotinic receptors
by: Marios Zouridakis, et al.
Published: (2022-08-01)

RgIA4 Potently Blocks Mouse α9α10 nAChRs and Provides Long Lasting Protection against Oxaliplatin-Induced Cold Allodynia
by: Sean B. Christensen, et al.
Published: (2017-07-01)

Neuronal Nicotinic Acetylcholine Receptor Modulators from Cone Snails
by: Nikita Abraham, et al.
Published: (2018-06-01)

αM-Conotoxin MIIIJ Blocks Nicotinic Acetylcholine Receptors at Neuromuscular Junctions of Frog and Fish
by: Matthew J. Rybin, et al.
Published: (2020-03-01)

Nicotinic acetylcholine receptor subtype expression, function, and pharmacology: Therapeutic potential of α-conotoxins
by: Han-Shen Tae, et al.
Published: (2023-05-01)

Conotoxin Interactions with α9α10-nAChRs: Is the α9α10-Nicotinic Acetylcholine Receptor an Important Therapeutic Target for Pain Management?
by: Sarasa A. Mohammadi, et al.
Published: (2015-09-01)

<span style="font-variant: small-caps">d</span>-Amino Acid Substitution of α-Conotoxin RgIA Identifies its Critical Residues and Improves the Enzymatic Stability
by: Jie Ren, et al.
Published: (2019-02-01)

Rational Design of Potent α-Conotoxin PeIA Analogues with Non-Natural Amino Acids for the Inhibition of Human α9α10 Nicotinic Acetylcholine Receptors
by: Tianmiao Li, et al.
Published: (2024-02-01)

αO-Conotoxin GeXIVA[1,2] Reduced Neuropathic Pain and Changed Gene Expression in Chronic Oxaliplatin-Induced Neuropathy Mice Model
by: Huanbai Wang, et al.
Published: (2024-01-01)

Comparative functional expression of nAChR subtypes in rodent DRG neurons
by: Nathan J. Smith, et al.
Published: (2013-11-01)

Synthetic α-Conotoxin Mutants as Probes for Studying Nicotinic Acetylcholine Receptors and in the Development of Novel Drug Leads
by: Christopher J. Armishaw
Published: (2010-06-01)

Immuno-modulatory activity of Rasayana Churna (An Ayurvedic compound formulation) in wistar albino rats
by: Chaudhari Swapnil, et al.
Published: (2019-01-01)

Immuno-modulatory activity of Rasayana Churna (An Ayurvedic compound formulation) in wistar albino rats
by: Chaudhari Swapnil, et al.
Published: (2018-01-01)

Canonical and Novel Non-Canonical Cholinergic Agonists Inhibit ATP-Induced Release of Monocytic Interleukin-1β via Different Combinations of Nicotinic Acetylcholine Receptor Subunits α7, α9 and α10
by: Anna Zakrzewicz, et al.
Published: (2017-07-01)

Conotoxins: Therapeutic Potential and Application
by: Richard T. Layer, et al.
Published: (2006-04-01)

IN VITRO CYTOTOXICITY STUDY OF AGAVE AMERICANA, STRYCHNOS NUX-VOMICA AND ARECA CATECHU EXTRACTS USING MCF-7 CELL LINE
by: Anajwala Chetan C., et al.
Published: (2010-06-01)

Cervical Cancer Correlates with the Differential Expression of Nicotinic Acetylcholine Receptors and Reveals Therapeutic Targets
by: Yiqiao Liu, et al.
Published: (2019-04-01)

C-Reactive Protein Stimulates Nicotinic Acetylcholine Receptors to Control ATP-Mediated Monocytic Inflammasome Activation
by: Katrin Richter, et al.
Published: (2018-07-01)

Conotoxins Targeting Nicotinic Acetylcholine Receptors: An Overview
by: Eline K. M. Lebbe, et al.
Published: (2014-05-01)

Venom-Derived Neurotoxins Targeting Nicotinic Acetylcholine Receptors
by: Ayaulym Bekbossynova, et al.
Published: (2021-06-01)

Synthesis and characterization of ZnO phytonanocomposite using Strychnos nux-vomica L. (Loganiaceae) and antimicrobial activity against multidrug-resistant bacterial strains from diabetic foot ulcer
by: Katherin Steffy, et al.
Published: (2018-01-01)

Cy3-RgIA-5727 Labels and Inhibits α9-Containing nAChRs of Cochlear Hair Cells
by: Fernando Fisher, et al.
Published: (2021-07-01)

Pharmacological Evaluation of Total Alkaloids from Nux Vomica: Effect of Reducing Strychnine Contents
by: Jun Chen, et al.
Published: (2014-04-01)

Molecular Determinants of Species Specificity of α-Conotoxin TxIB towards Rat and Human α6/α3β4 Nicotinic Acetylcholine Receptors
by: Ting Xie, et al.
Published: (2023-05-01)

Homomeric and Heteromeric α7 Nicotinic Acetylcholine Receptors in Health and Some Central Nervous System Diseases
by: Virginia Borroni, et al.
Published: (2021-08-01)

RgIA4 Prevention of Acute Oxaliplatin-Induced Cold Allodynia Requires α9-Containing Nicotinic Acetylcholine Receptors and CD3<sup>+</sup> T-Cells
by: Peter N. Huynh, et al.
Published: (2022-11-01)

Monkey adrenal chromaffin cells express α6β4* nicotinic acetylcholine receptors.
by: Alicia Hernández-Vivanco, et al.
Published: (2014-01-01)

Lyophilization Serves as an Effective Strategy for Drug Development of the α9α10 Nicotinic Acetylcholine Receptor Antagonist α-Conotoxin GeXIVA[1,2]
by: Zhiguo Li, et al.
Published: (2021-02-01)

A Novel α4/7-Conotoxin QuIA Selectively Inhibits α3β2 and α6/α3β4 Nicotinic Acetylcholine Receptor Subtypes with High Efficacy
by: Liujun Wang, et al.
Published: (2022-02-01)

Differential Expression of Nicotine Acetylcholine Receptors Associates with Human Breast Cancer and Mediates Antitumor Activity of αO-Conotoxin GeXIVA
by: Zhihua Sun, et al.
Published: (2020-01-01)

Interaction of α9α10 Nicotinic Receptors With Peptides and Proteins From Animal Venoms
by: Victor Tsetlin, et al.
Published: (2021-12-01)

Effects of C-Terminal Carboxylation on α-Conotoxin LsIA Interactions with Human α7 Nicotinic Acetylcholine Receptor: Molecular Simulation Studies
by: Jierong Wen, et al.
Published: (2019-04-01)

Interactions of the α3β2 Nicotinic Acetylcholine Receptor Interfaces with α-Conotoxin LsIA and its Carboxylated C-terminus Analogue: Molecular Dynamics Simulations
by: Jierong Wen, et al.
Published: (2020-07-01)

The 3/4- and 3/6-Subfamily Variants of α-Conotoxins GI and MI Exhibit Potent Inhibitory Activity against Muscular Nicotinic Acetylcholine Receptors
by: Xiaoli Ma, et al.
Published: (2021-12-01)

Unravelling the allosteric binding mode of αD-VxXXB at nicotinic acetylcholine receptors
by: Thao NT Ho, et al.
Published: (2023-04-01)

Subtype-Selective Peptide and Protein Neurotoxic Inhibitors of Nicotinic Acetylcholine Receptors Enhance Proliferation of Patient-Derived Glioblastoma Cell Lines
by: Elena Gondarenko, et al.
Published: (2024-02-01)