Prevalence, Patterns, and Genetic Association Analysis of Modic Vertebral Endplate Changes
Study DesignA prospective genetic association study.PurposeThe etiology of Modic changes (MCs) is unclear. Recently, the role of genetic factors in the etiology of MCs has been evaluated. However, studies with a larger patient subset are lacking, and candidate genes involved in other disc degenerati...
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| Format: | Article |
| Language: | English |
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Korean Spine Society
2017-08-01
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| Series: | Asian Spine Journal |
| Subjects: | |
| Online Access: | http://www.asianspinejournal.org/upload/pdf/asj-11-594.pdf |
| _version_ | 1819148302766047232 |
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| author | Rishi Mugesh Kanna Rajasekaran Shanmuganathan Veera Ranjani Rajagopalan Senthil Natesan Raveendran Muthuraja Kenneth Man Chee Cheung Danny Chan Patrick Yu Ping Kao Anita Yee Ajoy Prasad Shetty |
| author_facet | Rishi Mugesh Kanna Rajasekaran Shanmuganathan Veera Ranjani Rajagopalan Senthil Natesan Raveendran Muthuraja Kenneth Man Chee Cheung Danny Chan Patrick Yu Ping Kao Anita Yee Ajoy Prasad Shetty |
| author_sort | Rishi Mugesh Kanna |
| collection | DOAJ |
| description | Study DesignA prospective genetic association study.PurposeThe etiology of Modic changes (MCs) is unclear. Recently, the role of genetic factors in the etiology of MCs has been evaluated. However, studies with a larger patient subset are lacking, and candidate genes involved in other disc degeneration phenotypes have not been evaluated. We studied the prevalence of MCs and genetic association of 41 candidate genes in a large Indian cohort.Overview of LiteratureMCs are vertebral endplate signal changes predominantly observed in the lumbar spine. A significant association between MCs and lumbar disc degeneration and nonspecific low back pain has been described, with the etiopathogenesis implicating various mechanical, infective, and biochemical factors.MethodsWe studied 809 patients using 1.5-T magnetic resonance imaging to determine the prevalence, patterns, distribution, and type of lumbar MCs. Genetic association analysis of 71 single nucleotide polymorphisms (SNPs) of 41 candidate genes was performed based on the presence or absence of MCs. SNPs were genotyped using the Sequenome platform, and an association test was performed using PLINK software.ResultsThe mean age of the study population (n=809) was 36.7±10.8 years. Based on the presence of MCs, the cohort was divided into 702 controls and 107 cases (prevalence, 13%). MCs were more commonly present in the lower (149/251, 59.4%) than in the upper (102/251, 40.6%) endplates. L4–5 endplates were the most commonly affected levels (30.7%). Type 2 MCs were the most commonly observed pattern (n=206, 82%). The rs2228570 SNP of VDR (p=0.02) and rs17099008 SNP of MMP20 (p=0.03) were significantly associated with MCs.ConclusionsGenetic polymorphisms of SNPs of VDR and MMP20 were significantly associated with MCs. Understanding the etiopathogenetic mechanisms of MCs is important for planning preventive and therapeutic strategies. |
| first_indexed | 2024-12-22T13:43:34Z |
| format | Article |
| id | doaj.art-13e630559859407dafc1c24cfc2e7b1d |
| institution | Directory Open Access Journal |
| issn | 1976-1902 1976-7846 |
| language | English |
| last_indexed | 2024-12-22T13:43:34Z |
| publishDate | 2017-08-01 |
| publisher | Korean Spine Society |
| record_format | Article |
| series | Asian Spine Journal |
| spelling | doaj.art-13e630559859407dafc1c24cfc2e7b1d2022-12-21T18:23:51ZengKorean Spine SocietyAsian Spine Journal1976-19021976-78462017-08-0111459460010.4184/asj.2017.11.4.594263Prevalence, Patterns, and Genetic Association Analysis of Modic Vertebral Endplate ChangesRishi Mugesh Kanna0Rajasekaran Shanmuganathan1Veera Ranjani Rajagopalan2Senthil Natesan3Raveendran Muthuraja4Kenneth Man Chee Cheung5Danny Chan6Patrick Yu Ping Kao7Anita Yee8Ajoy Prasad Shetty9Department of Orthopaedics and Spine Surgery, Ganga Hospital, Coimbatore, India.Department of Orthopaedics and Spine Surgery, Ganga Hospital, Coimbatore, India.Department of Plant Genomics, Tamilnadu Agricultural University, Coimbatore, India.Department of Plant Genomics, Tamilnadu Agricultural University, Coimbatore, India.Department of Plant Genomics, Tamilnadu Agricultural University, Coimbatore, India.Department of Orthopedics, University of Hong Kong, Hong Kong.Department of Orthopedics, University of Hong Kong, Hong Kong.Department of Orthopedics, University of Hong Kong, Hong Kong.Department of Orthopedics, University of Hong Kong, Hong Kong.Department of Orthopaedics and Spine Surgery, Ganga Hospital, Coimbatore, India.Study DesignA prospective genetic association study.PurposeThe etiology of Modic changes (MCs) is unclear. Recently, the role of genetic factors in the etiology of MCs has been evaluated. However, studies with a larger patient subset are lacking, and candidate genes involved in other disc degeneration phenotypes have not been evaluated. We studied the prevalence of MCs and genetic association of 41 candidate genes in a large Indian cohort.Overview of LiteratureMCs are vertebral endplate signal changes predominantly observed in the lumbar spine. A significant association between MCs and lumbar disc degeneration and nonspecific low back pain has been described, with the etiopathogenesis implicating various mechanical, infective, and biochemical factors.MethodsWe studied 809 patients using 1.5-T magnetic resonance imaging to determine the prevalence, patterns, distribution, and type of lumbar MCs. Genetic association analysis of 71 single nucleotide polymorphisms (SNPs) of 41 candidate genes was performed based on the presence or absence of MCs. SNPs were genotyped using the Sequenome platform, and an association test was performed using PLINK software.ResultsThe mean age of the study population (n=809) was 36.7±10.8 years. Based on the presence of MCs, the cohort was divided into 702 controls and 107 cases (prevalence, 13%). MCs were more commonly present in the lower (149/251, 59.4%) than in the upper (102/251, 40.6%) endplates. L4–5 endplates were the most commonly affected levels (30.7%). Type 2 MCs were the most commonly observed pattern (n=206, 82%). The rs2228570 SNP of VDR (p=0.02) and rs17099008 SNP of MMP20 (p=0.03) were significantly associated with MCs.ConclusionsGenetic polymorphisms of SNPs of VDR and MMP20 were significantly associated with MCs. Understanding the etiopathogenetic mechanisms of MCs is important for planning preventive and therapeutic strategies.http://www.asianspinejournal.org/upload/pdf/asj-11-594.pdfPrevalenceModic changesGenetic association studiesSingle nucleotide polymorphism |
| spellingShingle | Rishi Mugesh Kanna Rajasekaran Shanmuganathan Veera Ranjani Rajagopalan Senthil Natesan Raveendran Muthuraja Kenneth Man Chee Cheung Danny Chan Patrick Yu Ping Kao Anita Yee Ajoy Prasad Shetty Prevalence, Patterns, and Genetic Association Analysis of Modic Vertebral Endplate Changes Asian Spine Journal Prevalence Modic changes Genetic association studies Single nucleotide polymorphism |
| title | Prevalence, Patterns, and Genetic Association Analysis of Modic Vertebral Endplate Changes |
| title_full | Prevalence, Patterns, and Genetic Association Analysis of Modic Vertebral Endplate Changes |
| title_fullStr | Prevalence, Patterns, and Genetic Association Analysis of Modic Vertebral Endplate Changes |
| title_full_unstemmed | Prevalence, Patterns, and Genetic Association Analysis of Modic Vertebral Endplate Changes |
| title_short | Prevalence, Patterns, and Genetic Association Analysis of Modic Vertebral Endplate Changes |
| title_sort | prevalence patterns and genetic association analysis of modic vertebral endplate changes |
| topic | Prevalence Modic changes Genetic association studies Single nucleotide polymorphism |
| url | http://www.asianspinejournal.org/upload/pdf/asj-11-594.pdf |
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