Seronegative necrolytic acral erythema: A distinct clinical subset?
A patient was referred to us with asymptomatic, erythematous, nonitchy, scaly lesions present bilaterally on the dorsa of his feet and toes since the last 2 months. Both the legs had pitting edema as well. There were hyperkeratosis, focal parakeratosis, acanthosis and scattered spongiosis in the epi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2010-01-01
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| Series: | Indian Journal of Dermatology |
| Subjects: | |
| Online Access: | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2010;volume=55;issue=3;spage=259;epage=261;aulast=Panda |
| _version_ | 1819169543068581888 |
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| author | Panda S Lahiri K |
| author_facet | Panda S Lahiri K |
| author_sort | Panda S |
| collection | DOAJ |
| description | A patient was referred to us with asymptomatic, erythematous, nonitchy, scaly lesions present bilaterally on the dorsa of his feet and toes since the last 2 months. Both the legs had pitting edema as well. There were hyperkeratosis, focal parakeratosis, acanthosis and scattered spongiosis in the epidermis, and proliferation of capillaries with perivascular infiltration of lymphomononuclear cells in the dermis. There was no serological evidence of hepatitis C virus. Laboratory investigations revealed hypoalbuminemia and low-normal serum zinc. On clinicopathological correlation, we made a diagnosis of necrolytic acral erythema (NAE). The lesions responded dramatically to oral zinc sulfate and topical clobetasol propionate within 3 weeks with disappearance of edema and scaling and only a minimal residual erythema. This is the first reported case of NAE from Eastern India. NAE with negative serology for hepatitis C may be viewed as a distinct subset of the condition that had been originally described. |
| first_indexed | 2024-12-22T19:21:10Z |
| format | Article |
| id | doaj.art-13eced3f0df4407e947808270bab4da1 |
| institution | Directory Open Access Journal |
| issn | 0019-5154 1998-3611 |
| language | English |
| last_indexed | 2024-12-22T19:21:10Z |
| publishDate | 2010-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dermatology |
| spelling | doaj.art-13eced3f0df4407e947808270bab4da12022-12-21T18:15:22ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36112010-01-01553259261Seronegative necrolytic acral erythema: A distinct clinical subset?Panda SLahiri KA patient was referred to us with asymptomatic, erythematous, nonitchy, scaly lesions present bilaterally on the dorsa of his feet and toes since the last 2 months. Both the legs had pitting edema as well. There were hyperkeratosis, focal parakeratosis, acanthosis and scattered spongiosis in the epidermis, and proliferation of capillaries with perivascular infiltration of lymphomononuclear cells in the dermis. There was no serological evidence of hepatitis C virus. Laboratory investigations revealed hypoalbuminemia and low-normal serum zinc. On clinicopathological correlation, we made a diagnosis of necrolytic acral erythema (NAE). The lesions responded dramatically to oral zinc sulfate and topical clobetasol propionate within 3 weeks with disappearance of edema and scaling and only a minimal residual erythema. This is the first reported case of NAE from Eastern India. NAE with negative serology for hepatitis C may be viewed as a distinct subset of the condition that had been originally described.http://www.e-ijd.org/article.asp?issn=0019-5154;year=2010;volume=55;issue=3;spage=259;epage=261;aulast=Panda<i>Acral erythemahepatitis Cnecrolytic erythemaoral zinc</i> |
| spellingShingle | Panda S Lahiri K Seronegative necrolytic acral erythema: A distinct clinical subset? Indian Journal of Dermatology <i>Acral erythema hepatitis C necrolytic erythema oral zinc</i> |
| title | Seronegative necrolytic acral erythema: A distinct clinical subset? |
| title_full | Seronegative necrolytic acral erythema: A distinct clinical subset? |
| title_fullStr | Seronegative necrolytic acral erythema: A distinct clinical subset? |
| title_full_unstemmed | Seronegative necrolytic acral erythema: A distinct clinical subset? |
| title_short | Seronegative necrolytic acral erythema: A distinct clinical subset? |
| title_sort | seronegative necrolytic acral erythema a distinct clinical subset |
| topic | <i>Acral erythema hepatitis C necrolytic erythema oral zinc</i> |
| url | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2010;volume=55;issue=3;spage=259;epage=261;aulast=Panda |
| work_keys_str_mv | AT pandas seronegativenecrolyticacralerythemaadistinctclinicalsubset AT lahirik seronegativenecrolyticacralerythemaadistinctclinicalsubset |