Anti-Osteoporotic Effects of Commiphora Myrrha and Its Poly-Saccharide via Osteoclastogenesis Inhibition
In traditional oriental medicines, <i>Commiphora myrrha</i> and its resinous exudate (i.e., myrrh) are used as herbal remedies to treat various inflammatory and metabolic disorders. Until now, <i>C. myrrha</i>-derived herbal products are considered useful source for bioactive...
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MDPI AG
2021-05-01
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| author | Youn-Hwan Hwang Ami Lee Taesoo Kim Seon-A Jang Hyunil Ha |
| author_facet | Youn-Hwan Hwang Ami Lee Taesoo Kim Seon-A Jang Hyunil Ha |
| author_sort | Youn-Hwan Hwang |
| collection | DOAJ |
| description | In traditional oriental medicines, <i>Commiphora myrrha</i> and its resinous exudate (i.e., myrrh) are used as herbal remedies to treat various inflammatory and metabolic disorders. Until now, <i>C. myrrha</i>-derived herbal products are considered useful source for bioactive compounds to manage numerous human diseases. This study investigated the effects of water extract of <i>C. myrrha</i> resin (WCM) and its polysaccharide (WCM-PE) on modulatory effects of osteoclast differentiation and/or ovariectomized-induced bone loss. Oral administration of WCM (200 and 500 mg/kg/day for four weeks) notably decreased trabecular bone loss and lipid accumulation in the bone marrow cavity. WCM and WCM-PE dose-dependently inhibited receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and suppressed RANKL-mediated overexpression of c-Fos and nuclear factor of activated T cells, cytoplasmic 1, thereby downregulating osteoclast-specific gene (Atp6v0d2, DC-STAMP and cathepsin K) expression. Thus, our results suggest that WCM and WCM-PE are promising nutraceutical candidates for the management of osteoporosis in postmenopausal women. |
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| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-10T11:35:17Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
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| spelling | doaj.art-13ee05dbae2b4c7fb20d2a3427d3b7e22023-11-21T18:55:06ZengMDPI AGPlants2223-77472021-05-0110594510.3390/plants10050945Anti-Osteoporotic Effects of Commiphora Myrrha and Its Poly-Saccharide via Osteoclastogenesis InhibitionYoun-Hwan Hwang0Ami Lee1Taesoo Kim2Seon-A Jang3Hyunil Ha4Herbal Medicine Research Division, Korea Institute of Oriental Medicine (KIOM), 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, KoreaHerbal Medicine Research Division, Korea Institute of Oriental Medicine (KIOM), 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, KoreaHerbal Medicine Research Division, Korea Institute of Oriental Medicine (KIOM), 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, KoreaHerbal Medicine Research Division, Korea Institute of Oriental Medicine (KIOM), 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, KoreaHerbal Medicine Research Division, Korea Institute of Oriental Medicine (KIOM), 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, KoreaIn traditional oriental medicines, <i>Commiphora myrrha</i> and its resinous exudate (i.e., myrrh) are used as herbal remedies to treat various inflammatory and metabolic disorders. Until now, <i>C. myrrha</i>-derived herbal products are considered useful source for bioactive compounds to manage numerous human diseases. This study investigated the effects of water extract of <i>C. myrrha</i> resin (WCM) and its polysaccharide (WCM-PE) on modulatory effects of osteoclast differentiation and/or ovariectomized-induced bone loss. Oral administration of WCM (200 and 500 mg/kg/day for four weeks) notably decreased trabecular bone loss and lipid accumulation in the bone marrow cavity. WCM and WCM-PE dose-dependently inhibited receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and suppressed RANKL-mediated overexpression of c-Fos and nuclear factor of activated T cells, cytoplasmic 1, thereby downregulating osteoclast-specific gene (Atp6v0d2, DC-STAMP and cathepsin K) expression. Thus, our results suggest that WCM and WCM-PE are promising nutraceutical candidates for the management of osteoporosis in postmenopausal women.https://www.mdpi.com/2223-7747/10/5/945myrrhpolysaccharideosteoporosisosteoclastogenesismice |
| spellingShingle | Youn-Hwan Hwang Ami Lee Taesoo Kim Seon-A Jang Hyunil Ha Anti-Osteoporotic Effects of Commiphora Myrrha and Its Poly-Saccharide via Osteoclastogenesis Inhibition Plants myrrh polysaccharide osteoporosis osteoclastogenesis mice |
| title | Anti-Osteoporotic Effects of Commiphora Myrrha and Its Poly-Saccharide via Osteoclastogenesis Inhibition |
| title_full | Anti-Osteoporotic Effects of Commiphora Myrrha and Its Poly-Saccharide via Osteoclastogenesis Inhibition |
| title_fullStr | Anti-Osteoporotic Effects of Commiphora Myrrha and Its Poly-Saccharide via Osteoclastogenesis Inhibition |
| title_full_unstemmed | Anti-Osteoporotic Effects of Commiphora Myrrha and Its Poly-Saccharide via Osteoclastogenesis Inhibition |
| title_short | Anti-Osteoporotic Effects of Commiphora Myrrha and Its Poly-Saccharide via Osteoclastogenesis Inhibition |
| title_sort | anti osteoporotic effects of commiphora myrrha and its poly saccharide via osteoclastogenesis inhibition |
| topic | myrrh polysaccharide osteoporosis osteoclastogenesis mice |
| url | https://www.mdpi.com/2223-7747/10/5/945 |
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