ApoER2 expression increases Aβ production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of γ-secretase activity

ApoER2 expression increases Aβ production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of γ-secretase activity

<p>Abstract</p> <p>Background</p> <p>The generation of the amyloid-β peptide (Aβ) through the proteolytic processing of the amyloid precursor protein (APP) is a central event in the pathogenesis of Alzheimer's disease (AD). Recent studies highlight APP endocytosis...

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Bibliographic Details
Main Authors: Bu Guojun, Bronfman Francisca C, Inestrosa Nibaldo C, Escudero Claudia A, Araya Claudia, Cam Judy, Lee Jiyeon, Barría Maria, Fuentealba Rodrigo A, Marzolo Maria-Paz
Format: Article
Language:English
Published: BMC 2007-07-01
Series:Molecular Neurodegeneration
Online Access:http://www.molecularneurodegeneration.com/content/2/1/14

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