Xyloglucan, a Plant Polymer with Barrier Protective Properties over the Mucous Membranes: An Overview
Disruption of the epithelial barrier function has been recently associated with a variety of diseases, mainly at intestinal level, but also affecting the respiratory epithelium and other mucosal barriers. Non-pharmacological approaches such as xyloglucan, with demonstrated protective barrier propert...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/19/3/673 |
| _version_ | 1811270157584039936 |
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| author | Núria Piqué María del Carmen Gómez-Guillén María Pilar Montero |
| author_facet | Núria Piqué María del Carmen Gómez-Guillén María Pilar Montero |
| author_sort | Núria Piqué |
| collection | DOAJ |
| description | Disruption of the epithelial barrier function has been recently associated with a variety of diseases, mainly at intestinal level, but also affecting the respiratory epithelium and other mucosal barriers. Non-pharmacological approaches such as xyloglucan, with demonstrated protective barrier properties, are proposed as new alternatives for the management of a wide range of diseases, for which mucosal disruption and, particularly, tight junction alterations, is a common characteristic. Xyloglucan, a natural polysaccharide derived from tamarind seeds, possesses a “mucin-like” molecular structure that confers mucoadhesive properties, allowing xyloglucan formulations to act as a barrier capable of reducing bacterial adherence and invasion and to preserve tight junctions and paracellular flux, as observed in different in vitro and in vivo studies. In clinical trials, xyloglucan has been seen to reduce symptoms of gastroenteritis in adults and children, nasal disorders and dry eye syndrome. Similar mucosal protectors containing reticulated proteins have also been useful for the treatment of irritable bowel syndrome and urinary tract infections. The role of xyloglucan in other disorders with mucosal disruption, such as dermatological or other infectious diseases, deserves further research. In conclusion, xyloglucan, endowed with film-forming protective barrier properties, is a safe non-pharmacological alternative for the management of different diseases, such as gastrointestinal and nasal disorders. |
| first_indexed | 2024-04-12T21:55:51Z |
| format | Article |
| id | doaj.art-13eef28c8edb415aa7c1850a31960b04 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T21:55:51Z |
| publishDate | 2018-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-13eef28c8edb415aa7c1850a31960b042022-12-22T03:15:20ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-02-0119367310.3390/ijms19030673ijms19030673Xyloglucan, a Plant Polymer with Barrier Protective Properties over the Mucous Membranes: An OverviewNúria Piqué0María del Carmen Gómez-Guillén1María Pilar Montero2Department of Microbiology and Parasitology, Pharmacy Faculty, Universitat de Barcelona (UB), Diagonal Sud, Facultat de Farmàcia, Edifici A, Av Joan XXIII, 27-31, 08028 Barcelona, SpainInstitute of Food Science, Technology and Nutrition (ICTAN-CSIC), 28040 Madrid, SpainInstitute of Food Science, Technology and Nutrition (ICTAN-CSIC), 28040 Madrid, SpainDisruption of the epithelial barrier function has been recently associated with a variety of diseases, mainly at intestinal level, but also affecting the respiratory epithelium and other mucosal barriers. Non-pharmacological approaches such as xyloglucan, with demonstrated protective barrier properties, are proposed as new alternatives for the management of a wide range of diseases, for which mucosal disruption and, particularly, tight junction alterations, is a common characteristic. Xyloglucan, a natural polysaccharide derived from tamarind seeds, possesses a “mucin-like” molecular structure that confers mucoadhesive properties, allowing xyloglucan formulations to act as a barrier capable of reducing bacterial adherence and invasion and to preserve tight junctions and paracellular flux, as observed in different in vitro and in vivo studies. In clinical trials, xyloglucan has been seen to reduce symptoms of gastroenteritis in adults and children, nasal disorders and dry eye syndrome. Similar mucosal protectors containing reticulated proteins have also been useful for the treatment of irritable bowel syndrome and urinary tract infections. The role of xyloglucan in other disorders with mucosal disruption, such as dermatological or other infectious diseases, deserves further research. In conclusion, xyloglucan, endowed with film-forming protective barrier properties, is a safe non-pharmacological alternative for the management of different diseases, such as gastrointestinal and nasal disorders.http://www.mdpi.com/1422-0067/19/3/673xyloglucandiarrhoeagastroenteritisnasal obstructionrhinitisrhinosinusitisbarrier propertiesallergypreventive measuresmedical devices |
| spellingShingle | Núria Piqué María del Carmen Gómez-Guillén María Pilar Montero Xyloglucan, a Plant Polymer with Barrier Protective Properties over the Mucous Membranes: An Overview International Journal of Molecular Sciences xyloglucan diarrhoea gastroenteritis nasal obstruction rhinitis rhinosinusitis barrier properties allergy preventive measures medical devices |
| title | Xyloglucan, a Plant Polymer with Barrier Protective Properties over the Mucous Membranes: An Overview |
| title_full | Xyloglucan, a Plant Polymer with Barrier Protective Properties over the Mucous Membranes: An Overview |
| title_fullStr | Xyloglucan, a Plant Polymer with Barrier Protective Properties over the Mucous Membranes: An Overview |
| title_full_unstemmed | Xyloglucan, a Plant Polymer with Barrier Protective Properties over the Mucous Membranes: An Overview |
| title_short | Xyloglucan, a Plant Polymer with Barrier Protective Properties over the Mucous Membranes: An Overview |
| title_sort | xyloglucan a plant polymer with barrier protective properties over the mucous membranes an overview |
| topic | xyloglucan diarrhoea gastroenteritis nasal obstruction rhinitis rhinosinusitis barrier properties allergy preventive measures medical devices |
| url | http://www.mdpi.com/1422-0067/19/3/673 |
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