G Protein-Coupled Estrogen Receptor: A Potential Therapeutic Target in Cancer

G Protein-Coupled Estrogen Receptor: A Potential Therapeutic Target in Cancer

The G protein-coupled estrogen receptor (GPER) is a seven-transmembrane-domain receptor that mediates non-genomic estrogen related signaling. After ligand activation, GPER triggers multiple downstream pathways that exert diverse biological effects on the regulation of cell growth, migration and prog...

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Bibliographic Details
Main Authors: Shen Xu, Shan Yu, Daming Dong, Leo Tsz On Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Endocrinology
Subjects:
G protein-coupled estrogen receptor
cancer
signaling pathway
estrogen
non-genomic estrogen pathways
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00725/full

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