Safranal, an active constituent of saffron, ameliorates myocardial ischemia via reduction of oxidative stress and regulation of Ca2+ homeostasis

Safranal, an active constituent of saffron, ameliorates myocardial ischemia via reduction of oxidative stress and regulation of Ca2+ homeostasis

Safranal (SFR) is the major constituent of saffron. The purpose of this study was to observe the effect of SFR on myocardial ischemia induced by isoprenaline (ISO) and to explore its possible mechanism. The myocardial ischemia rat model was established by subcutaneous injection of ISO (85 mg/kg/d) o...

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Bibliographic Details
Main Authors: Yurun Xue, Weiyue Jin, Yucong Xue, Yuanyuan Zhang, Hongfang Wang, Yixin Zhang, Shengjiang Guan, Xi Chu, Jianping Zhang
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Journal of Pharmacological Sciences
Subjects:
Safranal
Myocardial ischemia
Oxidative stress
Cell contractility
L-type Ca2+ current
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861320300323

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