Effect of Acute Administration of loganin on Spatial Memory in Diabetic Male Rats
Purpose: Diabetes is associated with memory and learning disorder. The purpose of this study is to determine the effect of acute oral administration of loganin on memory in diabetic male rats. Methods: 42 male Wistar rats (250-300 g) were divided into six groups: Control, Diabetic (1 week), Diabetic...
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2013-02-01
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| Series: | Advanced Pharmaceutical Bulletin |
| Subjects: | |
| Online Access: | http://journals.tbzmed.ac.ir/PDF/APB/Manuscript/APB-3-91.pdf |
| _version_ | 1818789677281312768 |
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| author | Gisou Mohaddes Saeideh Hasani Azami Shirin Babri |
| author_facet | Gisou Mohaddes Saeideh Hasani Azami Shirin Babri |
| author_sort | Gisou Mohaddes |
| collection | DOAJ |
| description | Purpose: Diabetes is associated with memory and learning disorder. The purpose of this study is to determine the effect of acute oral administration of loganin on memory in diabetic male rats. Methods: 42 male Wistar rats (250-300 g) were divided into six groups: Control, Diabetic (1 week), Diabetic (12 weeks), Loganin, Diabetic (1 week) + Loganin, Diabetic (12 weeks) + Loganin. Diabetes was induced by IP injection of Streptozotocin (60 mg/kg). Loganin (40 mg/kg, po) was administrated 1 hour before test. Then, spatial memory was compared between groups with Morris Water Maze tests. Results: Administration of loganin during acquisition, significantly (p<0.05) decreased both escape latency and traveled distance to find hidden platform in 1 and 12 weeks diabetic rats. In evaluation of recall phase of memory, loganin significantly (p<0.05) increased time and distance spent in the target quadrant in 1 and 12 weeks diabetic rats. Conclusion: Acute administration of loganin could improve spatial memory in diabetic rats. |
| first_indexed | 2024-12-18T14:43:22Z |
| format | Article |
| id | doaj.art-13f10a7c6b694a06a6574317e41994ce |
| institution | Directory Open Access Journal |
| issn | 2228-5881 2251-7308 |
| language | English |
| last_indexed | 2024-12-18T14:43:22Z |
| publishDate | 2013-02-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Advanced Pharmaceutical Bulletin |
| spelling | doaj.art-13f10a7c6b694a06a6574317e41994ce2022-12-21T21:04:20ZengTabriz University of Medical SciencesAdvanced Pharmaceutical Bulletin2228-58812251-73082013-02-0131919510.5681/apb.2013.015Effect of Acute Administration of loganin on Spatial Memory in Diabetic Male RatsGisou MohaddesSaeideh Hasani AzamiShirin BabriPurpose: Diabetes is associated with memory and learning disorder. The purpose of this study is to determine the effect of acute oral administration of loganin on memory in diabetic male rats. Methods: 42 male Wistar rats (250-300 g) were divided into six groups: Control, Diabetic (1 week), Diabetic (12 weeks), Loganin, Diabetic (1 week) + Loganin, Diabetic (12 weeks) + Loganin. Diabetes was induced by IP injection of Streptozotocin (60 mg/kg). Loganin (40 mg/kg, po) was administrated 1 hour before test. Then, spatial memory was compared between groups with Morris Water Maze tests. Results: Administration of loganin during acquisition, significantly (p<0.05) decreased both escape latency and traveled distance to find hidden platform in 1 and 12 weeks diabetic rats. In evaluation of recall phase of memory, loganin significantly (p<0.05) increased time and distance spent in the target quadrant in 1 and 12 weeks diabetic rats. Conclusion: Acute administration of loganin could improve spatial memory in diabetic rats.http://journals.tbzmed.ac.ir/PDF/APB/Manuscript/APB-3-91.pdfLoganinDiabetesSpatial memoryRat |
| spellingShingle | Gisou Mohaddes Saeideh Hasani Azami Shirin Babri Effect of Acute Administration of loganin on Spatial Memory in Diabetic Male Rats Advanced Pharmaceutical Bulletin Loganin Diabetes Spatial memory Rat |
| title | Effect of Acute Administration of loganin on Spatial Memory in Diabetic Male Rats |
| title_full | Effect of Acute Administration of loganin on Spatial Memory in Diabetic Male Rats |
| title_fullStr | Effect of Acute Administration of loganin on Spatial Memory in Diabetic Male Rats |
| title_full_unstemmed | Effect of Acute Administration of loganin on Spatial Memory in Diabetic Male Rats |
| title_short | Effect of Acute Administration of loganin on Spatial Memory in Diabetic Male Rats |
| title_sort | effect of acute administration of loganin on spatial memory in diabetic male rats |
| topic | Loganin Diabetes Spatial memory Rat |
| url | http://journals.tbzmed.ac.ir/PDF/APB/Manuscript/APB-3-91.pdf |
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