Extraction of Galphimines from <i>Galphimia glauca</i> with Supercritical Carbon Dioxide
The anti-depressive and anxiolytic effect of galphimine B (isolated from <i>Galphimia glauca</i>) has been demonstrated by researchers. Therefore, it is necessary to explore extraction techniques that produce materials with adequate quality for pharmaceutical applications. In this work,...
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MDPI AG
2020-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/3/477 |
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| author | Francisco Javier Verónico Sánchez Octavio Elizalde Solis Alejandro Zamilpa Ricardo García Morales Ma. Dolores Pérez García Jesús E. Jiménez Ferrer Jaime Tortoriello |
| author_facet | Francisco Javier Verónico Sánchez Octavio Elizalde Solis Alejandro Zamilpa Ricardo García Morales Ma. Dolores Pérez García Jesús E. Jiménez Ferrer Jaime Tortoriello |
| author_sort | Francisco Javier Verónico Sánchez |
| collection | DOAJ |
| description | The anti-depressive and anxiolytic effect of galphimine B (isolated from <i>Galphimia glauca</i>) has been demonstrated by researchers. Therefore, it is necessary to explore extraction techniques that produce materials with adequate quality for pharmaceutical applications. In this work, supercritical extractions of galphimines from <i>Galphimia glauca</i> were performed in the presence of carbon dioxide. Pressure, temperature, particle diameter, and flow rate effects were examined to explore the conditions with the highest yield and the concentration profile of galphimines in the studied interval. The identification of the nor-seco triterpenoids and galphimine B and E was carried out by HPLC analyses. The mathematical modeling of the extraction curves was attained by the approaches proposed by Sovová and Papamichail et al. According to results, the highest yield 2.22% was obtained at 323.15 K, 326 μm, 3 L/min, and 33.75 MPa. Meanwhile, the content of galphimine B in the extract was, on average, 19.5 mg·g<sup>−1</sup>. |
| first_indexed | 2024-12-10T05:05:49Z |
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| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-10T05:05:49Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
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| spelling | doaj.art-13f339f2d19d4d40add81c4891195bdc2022-12-22T02:01:15ZengMDPI AGMolecules1420-30492020-01-0125347710.3390/molecules25030477molecules25030477Extraction of Galphimines from <i>Galphimia glauca</i> with Supercritical Carbon DioxideFrancisco Javier Verónico Sánchez0Octavio Elizalde Solis1Alejandro Zamilpa2Ricardo García Morales3Ma. Dolores Pérez García4Jesús E. Jiménez Ferrer5Jaime Tortoriello6Departamento de Ingeniería Química Petrolera and Sección de Estudios de Posgrado e Investigación, Escuela Superior de Ingeniería Química e Industrias Extractivas, Instituto Politécnico Nacional (IPN), Mexico City 07738, MexicoDepartamento de Ingeniería Química Petrolera and Sección de Estudios de Posgrado e Investigación, Escuela Superior de Ingeniería Química e Industrias Extractivas, Instituto Politécnico Nacional (IPN), Mexico City 07738, MexicoCentro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social (CIBIS-IMSS), Morelos 62790, MexicoDepartamento de Ingeniería Química Petrolera and Sección de Estudios de Posgrado e Investigación, Escuela Superior de Ingeniería Química e Industrias Extractivas, Instituto Politécnico Nacional (IPN), Mexico City 07738, MexicoCentro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social (CIBIS-IMSS), Morelos 62790, MexicoCentro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social (CIBIS-IMSS), Morelos 62790, MexicoCentro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social (CIBIS-IMSS), Morelos 62790, MexicoThe anti-depressive and anxiolytic effect of galphimine B (isolated from <i>Galphimia glauca</i>) has been demonstrated by researchers. Therefore, it is necessary to explore extraction techniques that produce materials with adequate quality for pharmaceutical applications. In this work, supercritical extractions of galphimines from <i>Galphimia glauca</i> were performed in the presence of carbon dioxide. Pressure, temperature, particle diameter, and flow rate effects were examined to explore the conditions with the highest yield and the concentration profile of galphimines in the studied interval. The identification of the nor-seco triterpenoids and galphimine B and E was carried out by HPLC analyses. The mathematical modeling of the extraction curves was attained by the approaches proposed by Sovová and Papamichail et al. According to results, the highest yield 2.22% was obtained at 323.15 K, 326 μm, 3 L/min, and 33.75 MPa. Meanwhile, the content of galphimine B in the extract was, on average, 19.5 mg·g<sup>−1</sup>.https://www.mdpi.com/1420-3049/25/3/477<i>galphimia glauca</i>galphimine bárnica rojasupercritical extractioncarbon dioxidekinetic modeling |
| spellingShingle | Francisco Javier Verónico Sánchez Octavio Elizalde Solis Alejandro Zamilpa Ricardo García Morales Ma. Dolores Pérez García Jesús E. Jiménez Ferrer Jaime Tortoriello Extraction of Galphimines from <i>Galphimia glauca</i> with Supercritical Carbon Dioxide Molecules <i>galphimia glauca</i> galphimine b árnica roja supercritical extraction carbon dioxide kinetic modeling |
| title | Extraction of Galphimines from <i>Galphimia glauca</i> with Supercritical Carbon Dioxide |
| title_full | Extraction of Galphimines from <i>Galphimia glauca</i> with Supercritical Carbon Dioxide |
| title_fullStr | Extraction of Galphimines from <i>Galphimia glauca</i> with Supercritical Carbon Dioxide |
| title_full_unstemmed | Extraction of Galphimines from <i>Galphimia glauca</i> with Supercritical Carbon Dioxide |
| title_short | Extraction of Galphimines from <i>Galphimia glauca</i> with Supercritical Carbon Dioxide |
| title_sort | extraction of galphimines from i galphimia glauca i with supercritical carbon dioxide |
| topic | <i>galphimia glauca</i> galphimine b árnica roja supercritical extraction carbon dioxide kinetic modeling |
| url | https://www.mdpi.com/1420-3049/25/3/477 |
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