Statin's role on blood pressure levels: Meta‐analysis based on randomized controlled trials
Abstract Statins have been proven to be effective in minimizing the risk of cardiovascular adverse events, however, their effect on BP variability is debatable with respect to their significance and their use as a potential anti‐hypertensive. Using a meta‐analysis approach, the aim of this study was...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-03-01
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| Series: | The Journal of Clinical Hypertension |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jch.14645 |
| _version_ | 1797645140509065216 |
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| author | Hui Ting Liu Nian Hua Deng Ze Fan Wu Zhan Yang Zhou Zhen Tian Xi Yan Liu Yan Xia Wang Hong Yu Zheng Yang Shao Ou Zhi Sheng Jiang |
| author_facet | Hui Ting Liu Nian Hua Deng Ze Fan Wu Zhan Yang Zhou Zhen Tian Xi Yan Liu Yan Xia Wang Hong Yu Zheng Yang Shao Ou Zhi Sheng Jiang |
| author_sort | Hui Ting Liu |
| collection | DOAJ |
| description | Abstract Statins have been proven to be effective in minimizing the risk of cardiovascular adverse events, however, their effect on BP variability is debatable with respect to their significance and their use as a potential anti‐hypertensive. Using a meta‐analysis approach, the aim of this study was to explore whether certain statins have the potential to lower blood pressure (BP). For the period 2002–2022, Scopus, PubMed, Web of Science, and the Cochrane Central Register of Controlled Trials databases were searched for the studies that examined the effect of statins on blood pressure in normotensive or hypertensive individuals. Randomized controlled clinical trials that investigated this effect were included based on our inclusion criteria. Our primary outcomes were changes in systolic and diastolic blood pressure (DBP). The final analysis of the study included 49 RCTs involving 45 173 participants randomized to receive either statins or placebo. Among the two groups, the total weighted mean difference (WMD) for systolic blood pressure (ΔSBP) was –1.42 (95% CI: –2.38, –0.46; p = .004) and diastolic blood pressure (ΔDBP) was 0.82 (95% CI: –1.28, –0.36; p = .0005). Despite various studies suggesting the efficacy of statins in blood pressure lowering to be significant and non‐significant both, we observed a decrease in SBP and DBP both, although the change was not as large and could be considered significant. A large multicenter, multi‐ethnic, large sample pool size, and a long period follow‐up study is still required to assert these claims. |
| first_indexed | 2024-03-11T14:41:49Z |
| format | Article |
| id | doaj.art-13f350f5cd74463f81aa0531a359fb68 |
| institution | Directory Open Access Journal |
| issn | 1524-6175 1751-7176 |
| language | English |
| last_indexed | 2024-03-11T14:41:49Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Clinical Hypertension |
| spelling | doaj.art-13f350f5cd74463f81aa0531a359fb682023-10-30T13:26:47ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762023-03-0125323825010.1111/jch.14645Statin's role on blood pressure levels: Meta‐analysis based on randomized controlled trialsHui Ting Liu0Nian Hua Deng1Ze Fan Wu2Zhan Yang Zhou3Zhen Tian4Xi Yan Liu5Yan Xia Wang6Hong Yu Zheng7Yang Shao Ou8Zhi Sheng Jiang9Institute of Cardiovascular Disease Key Laboratory for Arteriosclerosis of Hunan Province Hengyang Medical College University of South China Hengyang Hunan PR ChinaInstitute of Cardiovascular Disease Key Laboratory for Arteriosclerosis of Hunan Province Hengyang Medical College University of South China Hengyang Hunan PR ChinaInstitute of Cardiovascular Disease Key Laboratory for Arteriosclerosis of Hunan Province Hengyang Medical College University of South China Hengyang Hunan PR ChinaDepartment of Cardiology Fu Wai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing Beijing PR ChinaInstitute of Cardiovascular Disease Key Laboratory for Arteriosclerosis of Hunan Province Hengyang Medical College University of South China Hengyang Hunan PR ChinaInstitute of Cardiovascular Disease Key Laboratory for Arteriosclerosis of Hunan Province Hengyang Medical College University of South China Hengyang Hunan PR ChinaInstitute of Cardiovascular Disease Key Laboratory for Arteriosclerosis of Hunan Province Hengyang Medical College University of South China Hengyang Hunan PR ChinaInstitute of Cardiovascular Disease Key Laboratory for Arteriosclerosis of Hunan Province Hengyang Medical College University of South China Hengyang Hunan PR ChinaThe Second Hospital University of South China Hengyang Hunan PR ChinaInstitute of Cardiovascular Disease Key Laboratory for Arteriosclerosis of Hunan Province Hengyang Medical College University of South China Hengyang Hunan PR ChinaAbstract Statins have been proven to be effective in minimizing the risk of cardiovascular adverse events, however, their effect on BP variability is debatable with respect to their significance and their use as a potential anti‐hypertensive. Using a meta‐analysis approach, the aim of this study was to explore whether certain statins have the potential to lower blood pressure (BP). For the period 2002–2022, Scopus, PubMed, Web of Science, and the Cochrane Central Register of Controlled Trials databases were searched for the studies that examined the effect of statins on blood pressure in normotensive or hypertensive individuals. Randomized controlled clinical trials that investigated this effect were included based on our inclusion criteria. Our primary outcomes were changes in systolic and diastolic blood pressure (DBP). The final analysis of the study included 49 RCTs involving 45 173 participants randomized to receive either statins or placebo. Among the two groups, the total weighted mean difference (WMD) for systolic blood pressure (ΔSBP) was –1.42 (95% CI: –2.38, –0.46; p = .004) and diastolic blood pressure (ΔDBP) was 0.82 (95% CI: –1.28, –0.36; p = .0005). Despite various studies suggesting the efficacy of statins in blood pressure lowering to be significant and non‐significant both, we observed a decrease in SBP and DBP both, although the change was not as large and could be considered significant. A large multicenter, multi‐ethnic, large sample pool size, and a long period follow‐up study is still required to assert these claims.https://doi.org/10.1111/jch.14645fluvastatinpravastatinRCTsimvastatinstatins |
| spellingShingle | Hui Ting Liu Nian Hua Deng Ze Fan Wu Zhan Yang Zhou Zhen Tian Xi Yan Liu Yan Xia Wang Hong Yu Zheng Yang Shao Ou Zhi Sheng Jiang Statin's role on blood pressure levels: Meta‐analysis based on randomized controlled trials The Journal of Clinical Hypertension fluvastatin pravastatin RCT simvastatin statins |
| title | Statin's role on blood pressure levels: Meta‐analysis based on randomized controlled trials |
| title_full | Statin's role on blood pressure levels: Meta‐analysis based on randomized controlled trials |
| title_fullStr | Statin's role on blood pressure levels: Meta‐analysis based on randomized controlled trials |
| title_full_unstemmed | Statin's role on blood pressure levels: Meta‐analysis based on randomized controlled trials |
| title_short | Statin's role on blood pressure levels: Meta‐analysis based on randomized controlled trials |
| title_sort | statin s role on blood pressure levels meta analysis based on randomized controlled trials |
| topic | fluvastatin pravastatin RCT simvastatin statins |
| url | https://doi.org/10.1111/jch.14645 |
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