Long-lasting treatment for moderate-severe depressed facial scars: skin and hair derived new autologous tissue filler with subcision
Background Tissue filler injection is popular for tissue augmentation, but it is still not widely used for depressed scar correction because of the limitations of the existed materials. Objective This study was designed to observe the effects of a tissue-engineering filler derived from autologous sk...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-01-01
|
| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2020.1748854 |
| _version_ | 1797683587111190528 |
|---|---|
| author | Qi Chen Yue Yang Jiao Zhang Qingguo Zhang |
| author_facet | Qi Chen Yue Yang Jiao Zhang Qingguo Zhang |
| author_sort | Qi Chen |
| collection | DOAJ |
| description | Background Tissue filler injection is popular for tissue augmentation, but it is still not widely used for depressed scar correction because of the limitations of the existed materials. Objective This study was designed to observe the effects of a tissue-engineering filler derived from autologous skin and hairs for correction of moderate-severe depressed scars. Patients and methods Totally 40 volunteers with moderate-severe depressed scars were enrolled in. Keratin gel and fibroblast derived from autologous hairs and a small piece of skin were mixed with autoserum and then injected into the dermis of the deformities. The whole procedure for injection was: filling and leveling up the scars by 10% after adequate subcision and repeating the treatment every other 3 weeks for total 9 weeks. Clinical features at different time points of the scars were collected and assessed. Results Thirty-six patients followed the protocol completely, receiving at least 50% improvement in depth and size of scars (significant improvement) 1 year after the treatment, with 88.9% of them had ‘75% improvement or more improvement’ (excellent improvement). No severe complications were reported. Conclusion Autologous keratin and fibroblast as filler is an effective option for moderate-severe depressed scars correction with long-term efficacy and high satisfactory. |
| first_indexed | 2024-03-12T00:16:36Z |
| format | Article |
| id | doaj.art-13f3ead43208470ea3871f8b25c9e0bd |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:16:36Z |
| publishDate | 2022-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-13f3ead43208470ea3871f8b25c9e0bd2023-09-15T14:23:05ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532022-01-0133124725310.1080/09546634.2020.17488541748854Long-lasting treatment for moderate-severe depressed facial scars: skin and hair derived new autologous tissue filler with subcisionQi Chen0Yue Yang1Jiao Zhang2Qingguo Zhang3Auricular Plastic and Reconstructive Surgery Center, Plastic Surgery Hospital, Chinese Academy of Medical Sciences & Peking Union Medical CollegeDepartment of Breast Surgery, The Affiliated Cancer Hospital of Zhengzhou University Henan Cancer HospitalAuricular Plastic and Reconstructive Surgery Center, Plastic Surgery Hospital, Chinese Academy of Medical Sciences & Peking Union Medical CollegeAuricular Plastic and Reconstructive Surgery Center, Plastic Surgery Hospital, Chinese Academy of Medical Sciences & Peking Union Medical CollegeBackground Tissue filler injection is popular for tissue augmentation, but it is still not widely used for depressed scar correction because of the limitations of the existed materials. Objective This study was designed to observe the effects of a tissue-engineering filler derived from autologous skin and hairs for correction of moderate-severe depressed scars. Patients and methods Totally 40 volunteers with moderate-severe depressed scars were enrolled in. Keratin gel and fibroblast derived from autologous hairs and a small piece of skin were mixed with autoserum and then injected into the dermis of the deformities. The whole procedure for injection was: filling and leveling up the scars by 10% after adequate subcision and repeating the treatment every other 3 weeks for total 9 weeks. Clinical features at different time points of the scars were collected and assessed. Results Thirty-six patients followed the protocol completely, receiving at least 50% improvement in depth and size of scars (significant improvement) 1 year after the treatment, with 88.9% of them had ‘75% improvement or more improvement’ (excellent improvement). No severe complications were reported. Conclusion Autologous keratin and fibroblast as filler is an effective option for moderate-severe depressed scars correction with long-term efficacy and high satisfactory.http://dx.doi.org/10.1080/09546634.2020.1748854fibroblastkeratin gelsubcisiondepressed scarsoft tissue filler |
| spellingShingle | Qi Chen Yue Yang Jiao Zhang Qingguo Zhang Long-lasting treatment for moderate-severe depressed facial scars: skin and hair derived new autologous tissue filler with subcision Journal of Dermatological Treatment fibroblast keratin gel subcision depressed scar soft tissue filler |
| title | Long-lasting treatment for moderate-severe depressed facial scars: skin and hair derived new autologous tissue filler with subcision |
| title_full | Long-lasting treatment for moderate-severe depressed facial scars: skin and hair derived new autologous tissue filler with subcision |
| title_fullStr | Long-lasting treatment for moderate-severe depressed facial scars: skin and hair derived new autologous tissue filler with subcision |
| title_full_unstemmed | Long-lasting treatment for moderate-severe depressed facial scars: skin and hair derived new autologous tissue filler with subcision |
| title_short | Long-lasting treatment for moderate-severe depressed facial scars: skin and hair derived new autologous tissue filler with subcision |
| title_sort | long lasting treatment for moderate severe depressed facial scars skin and hair derived new autologous tissue filler with subcision |
| topic | fibroblast keratin gel subcision depressed scar soft tissue filler |
| url | http://dx.doi.org/10.1080/09546634.2020.1748854 |
| work_keys_str_mv | AT qichen longlastingtreatmentformoderateseveredepressedfacialscarsskinandhairderivednewautologoustissuefillerwithsubcision AT yueyang longlastingtreatmentformoderateseveredepressedfacialscarsskinandhairderivednewautologoustissuefillerwithsubcision AT jiaozhang longlastingtreatmentformoderateseveredepressedfacialscarsskinandhairderivednewautologoustissuefillerwithsubcision AT qingguozhang longlastingtreatmentformoderateseveredepressedfacialscarsskinandhairderivednewautologoustissuefillerwithsubcision |