Ultrastructure of cranial nerves of rats inoculated with rabies virus Ultraestrutura de nervos cranianos de ratos inoculados com o vírus da raiva
The V and VII cranial nerves of rats inoculated with rabies virus were studied by electron microscopy. The results were compared with the same cranial nerves of rats inoculated with rabies virus but vaccinated against the disease. The findings are those of axonal degeneration and intense demyelinati...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Academia Brasileira de Neurologia (ABNEURO)
1997-01-01
|
| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1997000500002 |
| _version_ | 1819069579784093696 |
|---|---|
| author | Guilberto Minguetti Robin M. Hofmeister Yasuyoshi Hayashi Juan A. Montaño |
| author_facet | Guilberto Minguetti Robin M. Hofmeister Yasuyoshi Hayashi Juan A. Montaño |
| author_sort | Guilberto Minguetti |
| collection | DOAJ |
| description | The V and VII cranial nerves of rats inoculated with rabies virus were studied by electron microscopy. The results were compared with the same cranial nerves of rats inoculated with rabies virus but vaccinated against the disease. The findings are those of axonal degeneration and intense demyelination of the nerves of the group of rats not vaccinated. The vaccinated rats showed some ultrastructural irrelevant alterations when compared with the other group. The degree of ultrastructural alterations found in the group of rats not vaccinated suggests that in rabies severe damage of the cranial nerves occurs and that this may be closely related to the clinical picture of the disease (hydrophobia). Furthermore, as far as the authors know, this has not been considered in the classic descriptions of rabies and it is possible that an immunologic process may take part in the demyelination observed in the present study.<br>Os autores estudaram o quinto e o sétimo nervos cranianos de ratos inoculados com o vírus da raiva. Os resultados foram comparados com os mesmos nervos cranianos de ratos inoculados com o vírus da raiva, porém vacinados contra a doença. Os achados no grupo não vacinado foram de degeneração axonal e intensa desmielinização dos nervos examinados. No grupo vacinado foram encontrados apenas discretas alterações da mielina, sem relevância do ponto de vista patológico. As grandes alterações ultraestruturais encontradas no grupo de ratos não vacinados sugerem que na raiva ocorram acentuadas alterações nos nervos cranianos e que tais alterações devem estar intimamente relacionadas ao quadro clínico da doença (hidrofobia). Além disso, é possível que tais alterações estejam associadas a um processo imunológico responsável também por acometimento sistêmico dos nervos periféricos. |
| first_indexed | 2024-12-21T16:52:17Z |
| format | Article |
| id | doaj.art-13f44a0d96a14e07833d7dcf12113351 |
| institution | Directory Open Access Journal |
| issn | 0004-282X 1678-4227 |
| language | English |
| last_indexed | 2024-12-21T16:52:17Z |
| publishDate | 1997-01-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-13f44a0d96a14e07833d7dcf121133512022-12-21T18:56:50ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria0004-282X1678-42271997-01-0155468068610.1590/S0004-282X1997000500002Ultrastructure of cranial nerves of rats inoculated with rabies virus Ultraestrutura de nervos cranianos de ratos inoculados com o vírus da raivaGuilberto MinguettiRobin M. HofmeisterYasuyoshi HayashiJuan A. MontañoThe V and VII cranial nerves of rats inoculated with rabies virus were studied by electron microscopy. The results were compared with the same cranial nerves of rats inoculated with rabies virus but vaccinated against the disease. The findings are those of axonal degeneration and intense demyelination of the nerves of the group of rats not vaccinated. The vaccinated rats showed some ultrastructural irrelevant alterations when compared with the other group. The degree of ultrastructural alterations found in the group of rats not vaccinated suggests that in rabies severe damage of the cranial nerves occurs and that this may be closely related to the clinical picture of the disease (hydrophobia). Furthermore, as far as the authors know, this has not been considered in the classic descriptions of rabies and it is possible that an immunologic process may take part in the demyelination observed in the present study.<br>Os autores estudaram o quinto e o sétimo nervos cranianos de ratos inoculados com o vírus da raiva. Os resultados foram comparados com os mesmos nervos cranianos de ratos inoculados com o vírus da raiva, porém vacinados contra a doença. Os achados no grupo não vacinado foram de degeneração axonal e intensa desmielinização dos nervos examinados. No grupo vacinado foram encontrados apenas discretas alterações da mielina, sem relevância do ponto de vista patológico. As grandes alterações ultraestruturais encontradas no grupo de ratos não vacinados sugerem que na raiva ocorram acentuadas alterações nos nervos cranianos e que tais alterações devem estar intimamente relacionadas ao quadro clínico da doença (hidrofobia). Além disso, é possível que tais alterações estejam associadas a um processo imunológico responsável também por acometimento sistêmico dos nervos periféricos.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1997000500002raivanervos cranianosmicroscopia eletrônicarabiescranial nerveselectron microscopy |
| spellingShingle | Guilberto Minguetti Robin M. Hofmeister Yasuyoshi Hayashi Juan A. Montaño Ultrastructure of cranial nerves of rats inoculated with rabies virus Ultraestrutura de nervos cranianos de ratos inoculados com o vírus da raiva Arquivos de Neuro-Psiquiatria raiva nervos cranianos microscopia eletrônica rabies cranial nerves electron microscopy |
| title | Ultrastructure of cranial nerves of rats inoculated with rabies virus Ultraestrutura de nervos cranianos de ratos inoculados com o vírus da raiva |
| title_full | Ultrastructure of cranial nerves of rats inoculated with rabies virus Ultraestrutura de nervos cranianos de ratos inoculados com o vírus da raiva |
| title_fullStr | Ultrastructure of cranial nerves of rats inoculated with rabies virus Ultraestrutura de nervos cranianos de ratos inoculados com o vírus da raiva |
| title_full_unstemmed | Ultrastructure of cranial nerves of rats inoculated with rabies virus Ultraestrutura de nervos cranianos de ratos inoculados com o vírus da raiva |
| title_short | Ultrastructure of cranial nerves of rats inoculated with rabies virus Ultraestrutura de nervos cranianos de ratos inoculados com o vírus da raiva |
| title_sort | ultrastructure of cranial nerves of rats inoculated with rabies virus ultraestrutura de nervos cranianos de ratos inoculados com o virus da raiva |
| topic | raiva nervos cranianos microscopia eletrônica rabies cranial nerves electron microscopy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1997000500002 |
| work_keys_str_mv | AT guilbertominguetti ultrastructureofcranialnervesofratsinoculatedwithrabiesvirusultraestruturadenervoscranianosderatosinoculadoscomovirusdaraiva AT robinmhofmeister ultrastructureofcranialnervesofratsinoculatedwithrabiesvirusultraestruturadenervoscranianosderatosinoculadoscomovirusdaraiva AT yasuyoshihayashi ultrastructureofcranialnervesofratsinoculatedwithrabiesvirusultraestruturadenervoscranianosderatosinoculadoscomovirusdaraiva AT juanamontano ultrastructureofcranialnervesofratsinoculatedwithrabiesvirusultraestruturadenervoscranianosderatosinoculadoscomovirusdaraiva |