In Silico Analysis of Huntingtin Homologs in Lower Eukaryotes
Huntington’s disease is a rare neurodegenerative and autosomal dominant disorder. HD is caused by a mutation in the gene coding for huntingtin (Htt). The result is the production of a mutant Htt with an abnormally long polyglutamine repeat that leads to pathological Htt aggregates. Although the stru...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-03-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/6/3214 |
| _version_ | 1797540472390942720 |
|---|---|
| author | Valentina Brandi Fabio Polticelli |
| author_facet | Valentina Brandi Fabio Polticelli |
| author_sort | Valentina Brandi |
| collection | DOAJ |
| description | Huntington’s disease is a rare neurodegenerative and autosomal dominant disorder. HD is caused by a mutation in the gene coding for huntingtin (Htt). The result is the production of a mutant Htt with an abnormally long polyglutamine repeat that leads to pathological Htt aggregates. Although the structure of human Htt has been determined, albeit at low resolution, its functions and how they are performed are largely unknown. Moreover, there is little information on the structure and function of Htt in other organisms. The comparison of Htt homologs can help to understand if there is a functional conservation of domains in the evolution of Htt in eukaryotes. In this work, through a computational approach, Htt homologs from lower eukaryotes have been analysed, identifying ordered domains and modelling their structure. Based on the structural models, a putative function for most of the domains has been predicted. A putative <i>C. elegans</i> Htt-like protein has also been analysed following the same approach. The results obtained support the notion that this protein is a orthologue of human Htt. |
| first_indexed | 2024-03-10T13:00:38Z |
| format | Article |
| id | doaj.art-13f59d5861044394be8c17480c390e88 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T13:00:38Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-13f59d5861044394be8c17480c390e882023-11-21T11:29:38ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-03-01226321410.3390/ijms22063214In Silico Analysis of Huntingtin Homologs in Lower EukaryotesValentina Brandi0Fabio Polticelli1Department of Sciences, Roma Tre University, 00146 Rome, ItalyDepartment of Sciences, Roma Tre University, 00146 Rome, ItalyHuntington’s disease is a rare neurodegenerative and autosomal dominant disorder. HD is caused by a mutation in the gene coding for huntingtin (Htt). The result is the production of a mutant Htt with an abnormally long polyglutamine repeat that leads to pathological Htt aggregates. Although the structure of human Htt has been determined, albeit at low resolution, its functions and how they are performed are largely unknown. Moreover, there is little information on the structure and function of Htt in other organisms. The comparison of Htt homologs can help to understand if there is a functional conservation of domains in the evolution of Htt in eukaryotes. In this work, through a computational approach, Htt homologs from lower eukaryotes have been analysed, identifying ordered domains and modelling their structure. Based on the structural models, a putative function for most of the domains has been predicted. A putative <i>C. elegans</i> Htt-like protein has also been analysed following the same approach. The results obtained support the notion that this protein is a orthologue of human Htt.https://www.mdpi.com/1422-0067/22/6/3214huntingtinmolecular modellingfunction prediction<i>Caenorhabditis elegans</i> |
| spellingShingle | Valentina Brandi Fabio Polticelli In Silico Analysis of Huntingtin Homologs in Lower Eukaryotes International Journal of Molecular Sciences huntingtin molecular modelling function prediction <i>Caenorhabditis elegans</i> |
| title | In Silico Analysis of Huntingtin Homologs in Lower Eukaryotes |
| title_full | In Silico Analysis of Huntingtin Homologs in Lower Eukaryotes |
| title_fullStr | In Silico Analysis of Huntingtin Homologs in Lower Eukaryotes |
| title_full_unstemmed | In Silico Analysis of Huntingtin Homologs in Lower Eukaryotes |
| title_short | In Silico Analysis of Huntingtin Homologs in Lower Eukaryotes |
| title_sort | in silico analysis of huntingtin homologs in lower eukaryotes |
| topic | huntingtin molecular modelling function prediction <i>Caenorhabditis elegans</i> |
| url | https://www.mdpi.com/1422-0067/22/6/3214 |
| work_keys_str_mv | AT valentinabrandi insilicoanalysisofhuntingtinhomologsinlowereukaryotes AT fabiopolticelli insilicoanalysisofhuntingtinhomologsinlowereukaryotes |