Peripheral brain-derived neurotrophic factor is related to cardiovascular risk factors in active and inactive elderly men
Regular exercise plays an important preventive and therapeutic role in heart and vascular diseases, and beneficially affects brain function. In blood, the effects of exercise appear to be very complex and could include protection of vascular endothelial cells via neurotrophic factors and decreased o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2016-06-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/pdf/bjmbr/v49n7/1414-431X-bjmbr-1414-431X20165253.pdf |
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| author | A. Zembron-Lacny W. Dziubek M. Rynkiewicz B. Morawin M. Woźniewski |
| author_facet | A. Zembron-Lacny W. Dziubek M. Rynkiewicz B. Morawin M. Woźniewski |
| author_sort | A. Zembron-Lacny |
| collection | DOAJ |
| description | Regular exercise plays an important preventive and therapeutic role in heart and vascular diseases, and beneficially affects brain function. In blood, the effects of exercise appear to be very complex and could include protection of vascular endothelial cells via neurotrophic factors and decreased oxidative stress. The purpose of this study was to identify the age-related changes in peripheral brain-derived neurotrophic factor (BDNF) and its relationship to oxidative damage and conventional cardiovascular disease (CVD) biomarkers, such as atherogenic index, C-reactive protein (hsCRP) and oxidized LDL (oxLDL), in active and inactive men. Seventeen elderly males (61-80 years) and 17 young males (20-24 years) participated in this study. According to the 6-min Åstrand-Rhyming bike test, the subjects were classified into active and inactive groups. The young and elderly active men had a significantly better lipoprotein profile and antioxidant status, as well as reduced oxidative damage and inflammatory state. The active young and elderly men had significantly higher plasma BDNF levels compared to their inactive peers. BDNF was correlated with VO2max (r=0.765, P<0.001). In addition, we observed a significant inverse correlation of BDNF with atherogenic index (TC/HDL), hsCRP and oxLDL. The findings demonstrate that a high level of cardiorespiratory fitness reflected in VO2max was associated with a higher level of circulating BDNF, which in turn was related to common CVD risk factors and oxidative damage markers in young and elderly men. |
| first_indexed | 2024-04-11T15:32:07Z |
| format | Article |
| id | doaj.art-13f77648247c485199876d16cfcfa91e |
| institution | Directory Open Access Journal |
| issn | 1414-431X |
| language | English |
| last_indexed | 2024-04-11T15:32:07Z |
| publishDate | 2016-06-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-13f77648247c485199876d16cfcfa91e2022-12-22T04:16:06ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X2016-06-0149710.1590/1414-431x20165253Peripheral brain-derived neurotrophic factor is related to cardiovascular risk factors in active and inactive elderly menA. Zembron-LacnyW. DziubekM. RynkiewiczB. MorawinM. WoźniewskiRegular exercise plays an important preventive and therapeutic role in heart and vascular diseases, and beneficially affects brain function. In blood, the effects of exercise appear to be very complex and could include protection of vascular endothelial cells via neurotrophic factors and decreased oxidative stress. The purpose of this study was to identify the age-related changes in peripheral brain-derived neurotrophic factor (BDNF) and its relationship to oxidative damage and conventional cardiovascular disease (CVD) biomarkers, such as atherogenic index, C-reactive protein (hsCRP) and oxidized LDL (oxLDL), in active and inactive men. Seventeen elderly males (61-80 years) and 17 young males (20-24 years) participated in this study. According to the 6-min Åstrand-Rhyming bike test, the subjects were classified into active and inactive groups. The young and elderly active men had a significantly better lipoprotein profile and antioxidant status, as well as reduced oxidative damage and inflammatory state. The active young and elderly men had significantly higher plasma BDNF levels compared to their inactive peers. BDNF was correlated with VO2max (r=0.765, P<0.001). In addition, we observed a significant inverse correlation of BDNF with atherogenic index (TC/HDL), hsCRP and oxLDL. The findings demonstrate that a high level of cardiorespiratory fitness reflected in VO2max was associated with a higher level of circulating BDNF, which in turn was related to common CVD risk factors and oxidative damage markers in young and elderly men.http://www.scielo.br/pdf/bjmbr/v49n7/1414-431X-bjmbr-1414-431X20165253.pdfNeurotrophinsLipoproteinsOxidative damageAgingCardiorespiratory fitness |
| spellingShingle | A. Zembron-Lacny W. Dziubek M. Rynkiewicz B. Morawin M. Woźniewski Peripheral brain-derived neurotrophic factor is related to cardiovascular risk factors in active and inactive elderly men Brazilian Journal of Medical and Biological Research Neurotrophins Lipoproteins Oxidative damage Aging Cardiorespiratory fitness |
| title | Peripheral brain-derived neurotrophic factor is related to cardiovascular risk factors in active and inactive elderly men |
| title_full | Peripheral brain-derived neurotrophic factor is related to cardiovascular risk factors in active and inactive elderly men |
| title_fullStr | Peripheral brain-derived neurotrophic factor is related to cardiovascular risk factors in active and inactive elderly men |
| title_full_unstemmed | Peripheral brain-derived neurotrophic factor is related to cardiovascular risk factors in active and inactive elderly men |
| title_short | Peripheral brain-derived neurotrophic factor is related to cardiovascular risk factors in active and inactive elderly men |
| title_sort | peripheral brain derived neurotrophic factor is related to cardiovascular risk factors in active and inactive elderly men |
| topic | Neurotrophins Lipoproteins Oxidative damage Aging Cardiorespiratory fitness |
| url | http://www.scielo.br/pdf/bjmbr/v49n7/1414-431X-bjmbr-1414-431X20165253.pdf |
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