Cystine/glutamate antiporter xCT deficiency reduces metastasis without impairing immune system function in breast cancer mouse models

Cystine/glutamate antiporter xCT deficiency reduces metastasis without impairing immune system function in breast cancer mouse models

Abstract Background The upregulation of antioxidant mechanisms is a common occurrence in cancer cells, as they strive to maintain balanced redox state and prevent oxidative damage. This includes the upregulation of the cystine/glutamate antiporter xCT, which plays a crucial role in protecting cancer...

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Bibliographic Details
Main Authors: Roberto Ruiu, Chiara Cossu, Antonella Iacoviello, Laura Conti, Elisabetta Bolli, Luca Ponzone, Jolanda Magri, Alekya Rumandla, Enzo Calautti, Federica Cavallo
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
xCT
SLC7A11
Immune system
Breast cancer
Metastasis
Metastatic niche
Online Access:https://doi.org/10.1186/s13046-023-02830-x

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