Effects of Pre-Pregnancy Overweight/Obesity on the Pattern of Association of Hypertension Susceptibility Genes with Preeclampsia
The aim of this study was to explore the effects of pre-pregnancy overweight/obesity on the pattern of association of hypertension susceptibility genes with preeclampsia (PE). Ten single-nucleotide polymorphisms (SNPs) of the 10 genome-wide association studies (GWAS)-significant hypertension/blood p...
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MDPI AG
2022-12-01
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| Online Access: | https://www.mdpi.com/2075-1729/12/12/2018 |
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| author | Maria Abramova Maria Churnosova Olesya Efremova Inna Aristova Evgeny Reshetnikov Alexey Polonikov Mikhail Churnosov Irina Ponomarenko |
| author_facet | Maria Abramova Maria Churnosova Olesya Efremova Inna Aristova Evgeny Reshetnikov Alexey Polonikov Mikhail Churnosov Irina Ponomarenko |
| author_sort | Maria Abramova |
| collection | DOAJ |
| description | The aim of this study was to explore the effects of pre-pregnancy overweight/obesity on the pattern of association of hypertension susceptibility genes with preeclampsia (PE). Ten single-nucleotide polymorphisms (SNPs) of the 10 genome-wide association studies (GWAS)-significant hypertension/blood pressure (BP) candidate genes were genotyped in 950 pregnant women divided into two cohorts according to their pre-pregnancy body mass index (preBMI): preBMI ≥ 25 (162 with PE and 159 control) and preBMI < 25 (290 with PE and 339 control). The PLINK software package was utilized to study the association (analyzed four genetic models using logistic regression). The functionality of PE-correlated loci was analyzed by performing an in silico database analysis. Two SNP hypertension/BP genes, rs805303 <i>BAG6</i> (OR: 0.36–0.66) and rs167479 <i>RGL3</i> (OR: 1.86), in subjects with preBMI ≥ 25 were associated with PE. No association between the studied SNPs and PE in the preBMI < 25 group was determined. Further analysis showed that two PE-associated SNPs are functional (have weighty eQTL, sQTL, regulatory, and missense values) and could be potentially implicated in PE development. In conclusion, this study was the first to discover the modifying influence of overweight/obesity on the pattern of association of GWAS-significant hypertension/BP susceptibility genes with PE: these genes are linked with PE in preBMI ≥ 25 pregnant women and are not PE-involved in the preBMI < 25 group. |
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| last_indexed | 2024-03-09T16:10:39Z |
| publishDate | 2022-12-01 |
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| series | Life |
| spelling | doaj.art-13f9473759c8472e963498e0680c0f812023-11-24T16:12:09ZengMDPI AGLife2075-17292022-12-011212201810.3390/life12122018Effects of Pre-Pregnancy Overweight/Obesity on the Pattern of Association of Hypertension Susceptibility Genes with PreeclampsiaMaria Abramova0Maria Churnosova1Olesya Efremova2Inna Aristova3Evgeny Reshetnikov4Alexey Polonikov5Mikhail Churnosov6Irina Ponomarenko7Department of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, RussiaDepartment of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, RussiaDepartment of Medical Genetics, Kharkiv National Medical University, 61022 Kharkov, UkraineDepartment of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, RussiaDepartment of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, RussiaDepartment of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, RussiaDepartment of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, RussiaDepartment of Medical Biological Disciplines, Belgorod State National Research University, 308015 Belgorod, RussiaThe aim of this study was to explore the effects of pre-pregnancy overweight/obesity on the pattern of association of hypertension susceptibility genes with preeclampsia (PE). Ten single-nucleotide polymorphisms (SNPs) of the 10 genome-wide association studies (GWAS)-significant hypertension/blood pressure (BP) candidate genes were genotyped in 950 pregnant women divided into two cohorts according to their pre-pregnancy body mass index (preBMI): preBMI ≥ 25 (162 with PE and 159 control) and preBMI < 25 (290 with PE and 339 control). The PLINK software package was utilized to study the association (analyzed four genetic models using logistic regression). The functionality of PE-correlated loci was analyzed by performing an in silico database analysis. Two SNP hypertension/BP genes, rs805303 <i>BAG6</i> (OR: 0.36–0.66) and rs167479 <i>RGL3</i> (OR: 1.86), in subjects with preBMI ≥ 25 were associated with PE. No association between the studied SNPs and PE in the preBMI < 25 group was determined. Further analysis showed that two PE-associated SNPs are functional (have weighty eQTL, sQTL, regulatory, and missense values) and could be potentially implicated in PE development. In conclusion, this study was the first to discover the modifying influence of overweight/obesity on the pattern of association of GWAS-significant hypertension/BP susceptibility genes with PE: these genes are linked with PE in preBMI ≥ 25 pregnant women and are not PE-involved in the preBMI < 25 group.https://www.mdpi.com/2075-1729/12/12/2018BMIhypertension genespreeclampsiaSNPassociation |
| spellingShingle | Maria Abramova Maria Churnosova Olesya Efremova Inna Aristova Evgeny Reshetnikov Alexey Polonikov Mikhail Churnosov Irina Ponomarenko Effects of Pre-Pregnancy Overweight/Obesity on the Pattern of Association of Hypertension Susceptibility Genes with Preeclampsia Life BMI hypertension genes preeclampsia SNP association |
| title | Effects of Pre-Pregnancy Overweight/Obesity on the Pattern of Association of Hypertension Susceptibility Genes with Preeclampsia |
| title_full | Effects of Pre-Pregnancy Overweight/Obesity on the Pattern of Association of Hypertension Susceptibility Genes with Preeclampsia |
| title_fullStr | Effects of Pre-Pregnancy Overweight/Obesity on the Pattern of Association of Hypertension Susceptibility Genes with Preeclampsia |
| title_full_unstemmed | Effects of Pre-Pregnancy Overweight/Obesity on the Pattern of Association of Hypertension Susceptibility Genes with Preeclampsia |
| title_short | Effects of Pre-Pregnancy Overweight/Obesity on the Pattern of Association of Hypertension Susceptibility Genes with Preeclampsia |
| title_sort | effects of pre pregnancy overweight obesity on the pattern of association of hypertension susceptibility genes with preeclampsia |
| topic | BMI hypertension genes preeclampsia SNP association |
| url | https://www.mdpi.com/2075-1729/12/12/2018 |
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