Cerebral Malaria in Mouse and Man
Cerebral malaria (CM) is an acute encephalopathy caused by the malaria parasite Plasmodium falciparum, which develops in a small minority of infected patients and is responsible for the majority of deaths in African children. Despite decades of research on CM, the pathogenic mechanisms are still rel...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2018-09-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.02016/full |
| _version_ | 1818951275668045824 |
|---|---|
| author | Nazanin Ghazanfari Nazanin Ghazanfari Scott N. Mueller Scott N. Mueller William R. Heath William R. Heath |
| author_facet | Nazanin Ghazanfari Nazanin Ghazanfari Scott N. Mueller Scott N. Mueller William R. Heath William R. Heath |
| author_sort | Nazanin Ghazanfari |
| collection | DOAJ |
| description | Cerebral malaria (CM) is an acute encephalopathy caused by the malaria parasite Plasmodium falciparum, which develops in a small minority of infected patients and is responsible for the majority of deaths in African children. Despite decades of research on CM, the pathogenic mechanisms are still relatively poorly defined. Nevertheless, many studies in recent years, using a combination of animal models, in vitro cell culture work, and human patients, provide significant insight into the pathologic mechanisms leading to CM. In this review, we summarize recent findings from mouse models and human studies on the pathogenesis of CM, understanding of which may enable development of novel therapeutic approaches. |
| first_indexed | 2024-12-20T09:31:54Z |
| format | Article |
| id | doaj.art-13fc4f9be9ae4b4c90bbb6baf3fd064b |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-20T09:31:54Z |
| publishDate | 2018-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-13fc4f9be9ae4b4c90bbb6baf3fd064b2022-12-21T19:45:04ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-09-01910.3389/fimmu.2018.02016412582Cerebral Malaria in Mouse and ManNazanin Ghazanfari0Nazanin Ghazanfari1Scott N. Mueller2Scott N. Mueller3William R. Heath4William R. Heath5Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, AustraliaThe ARC Centre of Excellence in Advanced Molecular Imaging, University of Melbourne, Melbourne, VIC, AustraliaDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, AustraliaThe ARC Centre of Excellence in Advanced Molecular Imaging, University of Melbourne, Melbourne, VIC, AustraliaDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, VIC, AustraliaThe ARC Centre of Excellence in Advanced Molecular Imaging, University of Melbourne, Melbourne, VIC, AustraliaCerebral malaria (CM) is an acute encephalopathy caused by the malaria parasite Plasmodium falciparum, which develops in a small minority of infected patients and is responsible for the majority of deaths in African children. Despite decades of research on CM, the pathogenic mechanisms are still relatively poorly defined. Nevertheless, many studies in recent years, using a combination of animal models, in vitro cell culture work, and human patients, provide significant insight into the pathologic mechanisms leading to CM. In this review, we summarize recent findings from mouse models and human studies on the pathogenesis of CM, understanding of which may enable development of novel therapeutic approaches.https://www.frontiersin.org/article/10.3389/fimmu.2018.02016/fullcerebral malariaPlasmodium falciparumPlasmodium bergheiblood-brain barrierT cells |
| spellingShingle | Nazanin Ghazanfari Nazanin Ghazanfari Scott N. Mueller Scott N. Mueller William R. Heath William R. Heath Cerebral Malaria in Mouse and Man Frontiers in Immunology cerebral malaria Plasmodium falciparum Plasmodium berghei blood-brain barrier T cells |
| title | Cerebral Malaria in Mouse and Man |
| title_full | Cerebral Malaria in Mouse and Man |
| title_fullStr | Cerebral Malaria in Mouse and Man |
| title_full_unstemmed | Cerebral Malaria in Mouse and Man |
| title_short | Cerebral Malaria in Mouse and Man |
| title_sort | cerebral malaria in mouse and man |
| topic | cerebral malaria Plasmodium falciparum Plasmodium berghei blood-brain barrier T cells |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.02016/full |
| work_keys_str_mv | AT nazaninghazanfari cerebralmalariainmouseandman AT nazaninghazanfari cerebralmalariainmouseandman AT scottnmueller cerebralmalariainmouseandman AT scottnmueller cerebralmalariainmouseandman AT williamrheath cerebralmalariainmouseandman AT williamrheath cerebralmalariainmouseandman |