Environmental noise stress disturbs commensal microbiota homeostasis and induces oxi-inflammmation and AD-like neuropathology through epithelial barrier disruption in the EOAD mouse model

Environmental noise stress disturbs commensal microbiota homeostasis and induces oxi-inflammmation and AD-like neuropathology through epithelial barrier disruption in the EOAD mouse model

Abstract Background Both genetic factors and environmental hazards, including environmental noise stress, have been associated with gut microbiome that exacerbates Alzheimer’s disease (AD) pathology. However, the role and mechanism of environmental risk factors in early-onset AD (EOAD) pathogenesis...

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Bibliographic Details
Main Authors: Huimin Chi, Wa Cao, Ming Zhang, Donghong Su, Honglian Yang, Zhe Li, Chao Li, Xiaojun She, Kun Wang, Xiujie Gao, Kefeng Ma, Pengfang Zheng, Xiaofang Li, Bo Cui
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Neuroinflammation
Subjects:
Environmental noise
Microbiome–gut–brain axis
Oxidative stress
Inflammation
Early-onset Alzheimer’s disease (EOAD)
APP/PS1 mouse
Online Access:https://doi.org/10.1186/s12974-020-02053-3

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