Prion strains depend on different endocytic routes for productive infection

Prion strains depend on different endocytic routes for productive infection

Abstract Prions are unconventional agents composed of misfolded prion protein that cause fatal neurodegenerative diseases in mammals. Prion strains induce specific neuropathological changes in selected brain areas. The mechanism of strain-specific cell tropism is unknown. We hypothesised that prion...

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Bibliographic Details
Main Authors: Andrea Fehlinger, Hanna Wolf, André Hossinger, Yvonne Duernberger, Catharina Pleschka, Katrin Riemschoss, Shu Liu, Romina Bester, Lydia Paulsen, Suzette A. Priola, Martin H. Groschup, Hermann M. Schätzl, Ina M. Vorberg
Format: Article
Language:English
Published: Nature Portfolio 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-07260-2

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