Increased matrix metalloproteinase-9 in male elderly with low 25-hydroxy-vitamin D
Background One of the extra-skeletal roles of vitamin D for health is associated with cardiovascular disease. Poor vitamin D status has been associated with vascular endothelial dysfunction. There were controversial results about the association between vitamin D deficiency and matrix metalloprotei...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Faculty of Medicine Trisakti University
2016-12-01
|
| Series: | Universa Medicina |
| Subjects: | |
| Online Access: | https://univmed.org/ejurnal/index.php/medicina/article/view/367 |
| _version_ | 1818969782589849600 |
|---|---|
| author | Pusparini Pusparini Lie Tanu Merijanti Novia I. Sudharma |
| author_facet | Pusparini Pusparini Lie Tanu Merijanti Novia I. Sudharma |
| author_sort | Pusparini Pusparini |
| collection | DOAJ |
| description | Background
One of the extra-skeletal roles of vitamin D for health is associated with cardiovascular disease. Poor vitamin D status has been associated with vascular endothelial dysfunction. There were controversial results about the association between vitamin D deficiency and matrix metalloproteinase 9 (MMP-9) concentration. The purpose of the present study was to determine the concentrations of 25(OH) vitamin D [25(OH)D] in an elderly population and to find any association between 25(OH)D and MMP-9 concentrations.
Methods
This study was of cross-sectional design involving 160 male and female subjects aged 55–65 years, in South Jakarta, Indonesia. Determination of MMP-9 and 25(OH)D concentrations was done concurrently on subjects who met the inclusion and exclusion criteria after all study subjects had been selected. 25(OH)D and MMP-9 concentrations were assessed by direct competitive chemiluminescence immunoassay (CLIA) and enzyme-linked immunosorbent assay (ELISA) respectively. Statistical analysis used chi square and t tests.
Results
Mean 25(OH)D concentration in the study subjects was 14.4 ± 6.4 ng/mL. A total of 68.8% of subjects had a 25(OH)D level of <20 ng/mL, and 31.2 % had a 25(OH)D level of >20 ng/mL.There was an increased MMP-9 concentration in male subjects with a 25(OH)D level of <20 ng/mL compared with subjects with 25(OH)D level of >20 ng/mL (p=0.011), but not among female subjects (p=0.809).
Conclusion
The MMP-9 concentration was increased among male subjects with low level of (OH)D. This study confirmed that 25(OH)D concentration may have a potential role in endothelial function. |
| first_indexed | 2024-12-20T14:26:03Z |
| format | Article |
| id | doaj.art-13fe3abd360549dba312601bee2d8b34 |
| institution | Directory Open Access Journal |
| issn | 1907-3062 2407-2230 |
| language | English |
| last_indexed | 2024-12-20T14:26:03Z |
| publishDate | 2016-12-01 |
| publisher | Faculty of Medicine Trisakti University |
| record_format | Article |
| series | Universa Medicina |
| spelling | doaj.art-13fe3abd360549dba312601bee2d8b342022-12-21T19:37:47ZengFaculty of Medicine Trisakti UniversityUniversa Medicina1907-30622407-22302016-12-0135317118010.18051/UnivMed.2016.v35.171-180276Increased matrix metalloproteinase-9 in male elderly with low 25-hydroxy-vitamin DPusparini Pusparini0Lie Tanu Merijanti1Novia I. Sudharma2Department of Clinical Pathology, Faculty of Medicine, Trisakti University, Jakarta,IndonesiaDepartment of Occupational Medicine, Faculty of Medicine, Trisakti University, Jakarta, IndonesiaDepartment of Community Medicine, Faculty of Medicine, Trisakti University, Jakarta, IndonesiaBackground One of the extra-skeletal roles of vitamin D for health is associated with cardiovascular disease. Poor vitamin D status has been associated with vascular endothelial dysfunction. There were controversial results about the association between vitamin D deficiency and matrix metalloproteinase 9 (MMP-9) concentration. The purpose of the present study was to determine the concentrations of 25(OH) vitamin D [25(OH)D] in an elderly population and to find any association between 25(OH)D and MMP-9 concentrations. Methods This study was of cross-sectional design involving 160 male and female subjects aged 55–65 years, in South Jakarta, Indonesia. Determination of MMP-9 and 25(OH)D concentrations was done concurrently on subjects who met the inclusion and exclusion criteria after all study subjects had been selected. 25(OH)D and MMP-9 concentrations were assessed by direct competitive chemiluminescence immunoassay (CLIA) and enzyme-linked immunosorbent assay (ELISA) respectively. Statistical analysis used chi square and t tests. Results Mean 25(OH)D concentration in the study subjects was 14.4 ± 6.4 ng/mL. A total of 68.8% of subjects had a 25(OH)D level of <20 ng/mL, and 31.2 % had a 25(OH)D level of >20 ng/mL.There was an increased MMP-9 concentration in male subjects with a 25(OH)D level of <20 ng/mL compared with subjects with 25(OH)D level of >20 ng/mL (p=0.011), but not among female subjects (p=0.809). Conclusion The MMP-9 concentration was increased among male subjects with low level of (OH)D. This study confirmed that 25(OH)D concentration may have a potential role in endothelial function.https://univmed.org/ejurnal/index.php/medicina/article/view/367endothelial function, mmp-925(oh)dvitamin d deficientelderly |
| spellingShingle | Pusparini Pusparini Lie Tanu Merijanti Novia I. Sudharma Increased matrix metalloproteinase-9 in male elderly with low 25-hydroxy-vitamin D Universa Medicina endothelial function, mmp-9 25(oh)d vitamin d deficient elderly |
| title | Increased matrix metalloproteinase-9 in male elderly with low 25-hydroxy-vitamin D |
| title_full | Increased matrix metalloproteinase-9 in male elderly with low 25-hydroxy-vitamin D |
| title_fullStr | Increased matrix metalloproteinase-9 in male elderly with low 25-hydroxy-vitamin D |
| title_full_unstemmed | Increased matrix metalloproteinase-9 in male elderly with low 25-hydroxy-vitamin D |
| title_short | Increased matrix metalloproteinase-9 in male elderly with low 25-hydroxy-vitamin D |
| title_sort | increased matrix metalloproteinase 9 in male elderly with low 25 hydroxy vitamin d |
| topic | endothelial function, mmp-9 25(oh)d vitamin d deficient elderly |
| url | https://univmed.org/ejurnal/index.php/medicina/article/view/367 |
| work_keys_str_mv | AT pusparinipusparini increasedmatrixmetalloproteinase9inmaleelderlywithlow25hydroxyvitamind AT lietanumerijanti increasedmatrixmetalloproteinase9inmaleelderlywithlow25hydroxyvitamind AT noviaisudharma increasedmatrixmetalloproteinase9inmaleelderlywithlow25hydroxyvitamind |