Effects of soy isoflavonoids (genistein and daidzein) on endometrial receptivity
Objective(s): This study aimed to examine the effects of genistein and daidzein on endometrial receptivity by histopathological, immunohistochemical, and biochemical techniques.Materials and Methods: In this study, 72 female Sprague-Dawley rats were randomly divided into 8 groups. The endometrial re...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2020-12-01
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| Series: | Iranian Journal of Basic Medical Sciences |
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| Online Access: | https://ijbms.mums.ac.ir/article_16849_bc1a6ff346d9c435bdc5907eb2f5e9de.pdf |
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| author | Erdem Toktay Jale Selli Muhammed Gurbuz Tugba Tastan Rustem Anil Ugan Harun Un Zekai Halici |
| author_facet | Erdem Toktay Jale Selli Muhammed Gurbuz Tugba Tastan Rustem Anil Ugan Harun Un Zekai Halici |
| author_sort | Erdem Toktay |
| collection | DOAJ |
| description | Objective(s): This study aimed to examine the effects of genistein and daidzein on endometrial receptivity by histopathological, immunohistochemical, and biochemical techniques.Materials and Methods: In this study, 72 female Sprague-Dawley rats were randomly divided into 8 groups. The endometrial receptivity model was applied to identified groups. Experimental animals were given periorally 10 mg/kg and high 40 mg/kg doses of genistein and daidzein for 5 days by gavage. At the end of the experiment, uterine tissues were evaluated histopathologically, immunohistochemically, and biochemically. Results: When histopathological findings were examined, significant decreases in pinopod formation were observed in high dose genistein and daidzein groups. When compared with the endometrial receptivity group, immunohistochemical staining findings showed a significant decrease in the expression of integrin β3, integrin αvβ3, LIF, and HOXA10 and an increase in MUC 1 expression in the high dose of genistein and daidzein groups. In biochemical evaluations, it was determined that genistein and daidzein increased estrogen levels and decreased progesterone levels in a dose-dependent manner. Conclusion: Genistein and daidzein have a negative effect on endometrial receptivity. Therefore, individuals with a risk of infertility should pay attention to the consumption of genistein and daidzein. |
| first_indexed | 2024-04-12T20:08:45Z |
| format | Article |
| id | doaj.art-13feea99512b422e8b117361429d4f9b |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-04-12T20:08:45Z |
| publishDate | 2020-12-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-13feea99512b422e8b117361429d4f9b2022-12-22T03:18:19ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742020-12-0123121603160910.22038/ijbms.2020.48294.1108916849Effects of soy isoflavonoids (genistein and daidzein) on endometrial receptivityErdem Toktay0Jale Selli1Muhammed Gurbuz2Tugba Tastan3Rustem Anil Ugan4Harun Un5Zekai Halici6Kafkas University, Faculty of Medicine, Department of Histology and Embryology, KarsAlanya Alaaddin Keykubat University, Faculty of Medicine, Department of Histology and Embryology, AntalyaAtaturk University, Faculty of Medicine, Department of Histology and Embryology, ErzurumAtaturk University, Faculty of Medicine, Department of Histology and Embryology, ErzurumAtaturk University, Faculty of Pharmacy, Department of Pharmacology, ErzurumAgrı Ibrahim Cecen University, Faculty of Pharmacy, Department of biochemistry, AğrıAtaturk University, Faculty of Medicine, Department of Pharmacology, ErzurumObjective(s): This study aimed to examine the effects of genistein and daidzein on endometrial receptivity by histopathological, immunohistochemical, and biochemical techniques.Materials and Methods: In this study, 72 female Sprague-Dawley rats were randomly divided into 8 groups. The endometrial receptivity model was applied to identified groups. Experimental animals were given periorally 10 mg/kg and high 40 mg/kg doses of genistein and daidzein for 5 days by gavage. At the end of the experiment, uterine tissues were evaluated histopathologically, immunohistochemically, and biochemically. Results: When histopathological findings were examined, significant decreases in pinopod formation were observed in high dose genistein and daidzein groups. When compared with the endometrial receptivity group, immunohistochemical staining findings showed a significant decrease in the expression of integrin β3, integrin αvβ3, LIF, and HOXA10 and an increase in MUC 1 expression in the high dose of genistein and daidzein groups. In biochemical evaluations, it was determined that genistein and daidzein increased estrogen levels and decreased progesterone levels in a dose-dependent manner. Conclusion: Genistein and daidzein have a negative effect on endometrial receptivity. Therefore, individuals with a risk of infertility should pay attention to the consumption of genistein and daidzein.https://ijbms.mums.ac.ir/article_16849_bc1a6ff346d9c435bdc5907eb2f5e9de.pdfdaidzeinendometrial receptivitygenisteinratsoy isoflavonoids |
| spellingShingle | Erdem Toktay Jale Selli Muhammed Gurbuz Tugba Tastan Rustem Anil Ugan Harun Un Zekai Halici Effects of soy isoflavonoids (genistein and daidzein) on endometrial receptivity Iranian Journal of Basic Medical Sciences daidzein endometrial receptivity genistein rat soy isoflavonoids |
| title | Effects of soy isoflavonoids (genistein and daidzein) on endometrial receptivity |
| title_full | Effects of soy isoflavonoids (genistein and daidzein) on endometrial receptivity |
| title_fullStr | Effects of soy isoflavonoids (genistein and daidzein) on endometrial receptivity |
| title_full_unstemmed | Effects of soy isoflavonoids (genistein and daidzein) on endometrial receptivity |
| title_short | Effects of soy isoflavonoids (genistein and daidzein) on endometrial receptivity |
| title_sort | effects of soy isoflavonoids genistein and daidzein on endometrial receptivity |
| topic | daidzein endometrial receptivity genistein rat soy isoflavonoids |
| url | https://ijbms.mums.ac.ir/article_16849_bc1a6ff346d9c435bdc5907eb2f5e9de.pdf |
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