Association of rs2910164 in miR-146a with type 2 diabetes mellitus: A case–control and meta-analysis study
ObjectiveSeveral studies have shown that miR-146a rs2910164 (C > G) is associated with type 2 diabetes mellitus (T2DM) susceptibility, but the results are still controversial. This study is divided into two parts, and one is to explore the relationship between miR-146a rs2910164 polymorphism...
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| Format: | Article |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.961635/full |
| _version_ | 1811204018353995776 |
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| author | Wei-Wei Chang Li-Ying Wen Liu Zhang Xin Tong Yue-Long Jin Gui-Mei Chen |
| author_facet | Wei-Wei Chang Li-Ying Wen Liu Zhang Xin Tong Yue-Long Jin Gui-Mei Chen |
| author_sort | Wei-Wei Chang |
| collection | DOAJ |
| description | ObjectiveSeveral studies have shown that miR-146a rs2910164 (C > G) is associated with type 2 diabetes mellitus (T2DM) susceptibility, but the results are still controversial. This study is divided into two parts, and one is to explore the relationship between miR-146a rs2910164 polymorphism and the genetic susceptibility of T2DM in Chinese Han population. Second, a meta-analysis on the basis of a larger sample size was used to determine whether this is a susceptibility gene for T2DM.MethodsA case–control study including 574 T2DM patients and 596 controls was used to evaluate the association of miR-146a rs2910164 polymorphism with the risk of T2DM in Chinese Han People. Then, we systematically searched studies investigating the correlation between miR-146a rs2910164 polymorphism and T2DM susceptibility published before April 2022 from PubMed, Web of Science, Wanfang, and China National Knowledge Infrastructure database, and a meta-analysis including six studies was carried out. The results were expressed by odds ratio (OR) and its 95% confidence interval (95% CI).ResultsIn a case–control study, we found that there were no statistical differences in genotype frequencies between T2DM and control group. Subgroup analysis showed that, compared with the CC genotype, CG + GG genotype was associated with a decreased risk of T2DM in the subgroup of individuals ≥ 65 years old (OR = 0.75; 95% CI: 0.58–0.98; Padjusted = 0.032) and BMI < 18.5 (OR = 0.16; 95% CI: 0.03–0.89; Padjusted = 0.037). In overall meta-analysis, significant heterogeneity was detected. No significant association between miR-146a rs2910164 polymorphism and T2DM was observed in all genetic models under random effects models. Subgroup analysis revealed that there was a significant difference in genotype frequencies between the T2DM and control group in recessive model (CC vs. CG + GG: OR = 1.79; 95% CI: 1.08–2.96; PQ = 0.307, I2 = 4.0%) and homozygote model (CC vs. GG: OR = 1.79; 95% CI: 1.07–3.00; PQ = 0.216, I2 = 34.7%) in Caucasians.ConclusionThe results of our study demonstrate that the miR-146a rs2910164 polymorphism might have ethnicity-dependent effects in T2DM and may be related to T2DM susceptibility in Caucasians. |
| first_indexed | 2024-04-12T03:05:45Z |
| format | Article |
| id | doaj.art-13ff73e913544f69bac25dda0d1c134e |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-12T03:05:45Z |
| publishDate | 2022-09-01 |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-13ff73e913544f69bac25dda0d1c134e2022-12-22T03:50:31ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-09-011310.3389/fendo.2022.961635961635Association of rs2910164 in miR-146a with type 2 diabetes mellitus: A case–control and meta-analysis studyWei-Wei Chang0Li-Ying Wen1Liu Zhang2Xin Tong3Yue-Long Jin4Gui-Mei Chen5Department of Epidemiology and Health statistics, School of Public Health, Wannan Medical College, Wuhu, ChinaDepartment of Epidemiology and Health statistics, School of Public Health, Wannan Medical College, Wuhu, ChinaDepartment of Hospital Infection Management Office, Wuhu Hospital of Traditional Chinese Medicine, Wuhu, ChinaDepartment of Epidemiology and Health statistics, School of Public Health, Wannan Medical College, Wuhu, ChinaDepartment of Epidemiology and Health statistics, School of Public Health, Wannan Medical College, Wuhu, ChinaSchool of Health management, Anhui Medical University, Hefei, ChinaObjectiveSeveral studies have shown that miR-146a rs2910164 (C > G) is associated with type 2 diabetes mellitus (T2DM) susceptibility, but the results are still controversial. This study is divided into two parts, and one is to explore the relationship between miR-146a rs2910164 polymorphism and the genetic susceptibility of T2DM in Chinese Han population. Second, a meta-analysis on the basis of a larger sample size was used to determine whether this is a susceptibility gene for T2DM.MethodsA case–control study including 574 T2DM patients and 596 controls was used to evaluate the association of miR-146a rs2910164 polymorphism with the risk of T2DM in Chinese Han People. Then, we systematically searched studies investigating the correlation between miR-146a rs2910164 polymorphism and T2DM susceptibility published before April 2022 from PubMed, Web of Science, Wanfang, and China National Knowledge Infrastructure database, and a meta-analysis including six studies was carried out. The results were expressed by odds ratio (OR) and its 95% confidence interval (95% CI).ResultsIn a case–control study, we found that there were no statistical differences in genotype frequencies between T2DM and control group. Subgroup analysis showed that, compared with the CC genotype, CG + GG genotype was associated with a decreased risk of T2DM in the subgroup of individuals ≥ 65 years old (OR = 0.75; 95% CI: 0.58–0.98; Padjusted = 0.032) and BMI < 18.5 (OR = 0.16; 95% CI: 0.03–0.89; Padjusted = 0.037). In overall meta-analysis, significant heterogeneity was detected. No significant association between miR-146a rs2910164 polymorphism and T2DM was observed in all genetic models under random effects models. Subgroup analysis revealed that there was a significant difference in genotype frequencies between the T2DM and control group in recessive model (CC vs. CG + GG: OR = 1.79; 95% CI: 1.08–2.96; PQ = 0.307, I2 = 4.0%) and homozygote model (CC vs. GG: OR = 1.79; 95% CI: 1.07–3.00; PQ = 0.216, I2 = 34.7%) in Caucasians.ConclusionThe results of our study demonstrate that the miR-146a rs2910164 polymorphism might have ethnicity-dependent effects in T2DM and may be related to T2DM susceptibility in Caucasians.https://www.frontiersin.org/articles/10.3389/fendo.2022.961635/fullmir-146atype 2 diabetes mellitusmeta-analysiscase-controlpolymorphism |
| spellingShingle | Wei-Wei Chang Li-Ying Wen Liu Zhang Xin Tong Yue-Long Jin Gui-Mei Chen Association of rs2910164 in miR-146a with type 2 diabetes mellitus: A case–control and meta-analysis study Frontiers in Endocrinology mir-146a type 2 diabetes mellitus meta-analysis case-control polymorphism |
| title | Association of rs2910164 in miR-146a with type 2 diabetes mellitus: A case–control and meta-analysis study |
| title_full | Association of rs2910164 in miR-146a with type 2 diabetes mellitus: A case–control and meta-analysis study |
| title_fullStr | Association of rs2910164 in miR-146a with type 2 diabetes mellitus: A case–control and meta-analysis study |
| title_full_unstemmed | Association of rs2910164 in miR-146a with type 2 diabetes mellitus: A case–control and meta-analysis study |
| title_short | Association of rs2910164 in miR-146a with type 2 diabetes mellitus: A case–control and meta-analysis study |
| title_sort | association of rs2910164 in mir 146a with type 2 diabetes mellitus a case control and meta analysis study |
| topic | mir-146a type 2 diabetes mellitus meta-analysis case-control polymorphism |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.961635/full |
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