Design and validation of microfluidic parameters of a microfluidic chip using fluid dynamics
The internal fluidic parameters of microfluidic channels must be analyzed to solve fundamental microfluidic problems, including microscale transport problems involving thermal analysis, chemical reactivity, velocity, pressure drop, etc., for developing good-quality chemical and biological products....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
AIP Publishing LLC
2021-07-01
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| Series: | AIP Advances |
| Online Access: | http://dx.doi.org/10.1063/5.0056597 |
| _version_ | 1819153091418652672 |
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| author | Feroz Ahmed Yuichi Yoshida Jin Wang Kenji Sakai Toshihiko Kiwa |
| author_facet | Feroz Ahmed Yuichi Yoshida Jin Wang Kenji Sakai Toshihiko Kiwa |
| author_sort | Feroz Ahmed |
| collection | DOAJ |
| description | The internal fluidic parameters of microfluidic channels must be analyzed to solve fundamental microfluidic problems, including microscale transport problems involving thermal analysis, chemical reactivity, velocity, pressure drop, etc., for developing good-quality chemical and biological products. Therefore, the characterization and optimization of the interaction of chemical and biological solutions through microfluidic channels are vital for fluid flow design and engineering for quality assurance in microfluidic platforms. As the internal structures and kinetics of microfluidic channels are becoming increasingly complex, experiments involving optimal fluidic and transport designs are challenging to perform with high accuracy. However, highly integrated simulation tools can guide researchers without specialized computational fluid backgrounds to design numerical prototypes of highly integrated devices. In this study, a microfluidic chip with two inlet wells and one outlet well was fabricated from polydimethylsiloxane following which simulations were performed using an ANSYS Fluent tool influenced by computational fluid dynamics at a nearly identical scale. The pressure drop and velocity profiles of the interaction of two pH buffer solutions (pH 4 and 10) through the designed microfluidic chip were qualitatively estimated from experimental data analysis and validated with the simulation results obtained from the CFD-influenced ANSYS Fluent tool. |
| first_indexed | 2024-12-22T14:59:40Z |
| format | Article |
| id | doaj.art-1400ceb2ac994750a599581999d9eb79 |
| institution | Directory Open Access Journal |
| issn | 2158-3226 |
| language | English |
| last_indexed | 2024-12-22T14:59:40Z |
| publishDate | 2021-07-01 |
| publisher | AIP Publishing LLC |
| record_format | Article |
| series | AIP Advances |
| spelling | doaj.art-1400ceb2ac994750a599581999d9eb792022-12-21T18:22:09ZengAIP Publishing LLCAIP Advances2158-32262021-07-01117075224075224-910.1063/5.0056597Design and validation of microfluidic parameters of a microfluidic chip using fluid dynamicsFeroz Ahmed0Yuichi Yoshida1Jin Wang2Kenji Sakai3Toshihiko Kiwa4Graduate School of Natural Science and Technology, Department of Medical Bioengineering, Okayama University 3-1-1, Tsushima-naka, Kita-ku, Okayama 700-8530, JapanGraduate School of Interdisciplinary Science and Engineering in Health Systems, Department of Medical Bioengineering, Okayama University 3-1-1, Tsushima-naka, Kita-ku, Okayama 700-8530, JapanGraduate School of Interdisciplinary Science and Engineering in Health Systems, Department of Medical Bioengineering, Okayama University 3-1-1, Tsushima-naka, Kita-ku, Okayama 700-8530, JapanGraduate School of Interdisciplinary Science and Engineering in Health Systems, Department of Medical Bioengineering, Okayama University 3-1-1, Tsushima-naka, Kita-ku, Okayama 700-8530, JapanGraduate School of Interdisciplinary Science and Engineering in Health Systems, Department of Medical Bioengineering, Okayama University 3-1-1, Tsushima-naka, Kita-ku, Okayama 700-8530, JapanThe internal fluidic parameters of microfluidic channels must be analyzed to solve fundamental microfluidic problems, including microscale transport problems involving thermal analysis, chemical reactivity, velocity, pressure drop, etc., for developing good-quality chemical and biological products. Therefore, the characterization and optimization of the interaction of chemical and biological solutions through microfluidic channels are vital for fluid flow design and engineering for quality assurance in microfluidic platforms. As the internal structures and kinetics of microfluidic channels are becoming increasingly complex, experiments involving optimal fluidic and transport designs are challenging to perform with high accuracy. However, highly integrated simulation tools can guide researchers without specialized computational fluid backgrounds to design numerical prototypes of highly integrated devices. In this study, a microfluidic chip with two inlet wells and one outlet well was fabricated from polydimethylsiloxane following which simulations were performed using an ANSYS Fluent tool influenced by computational fluid dynamics at a nearly identical scale. The pressure drop and velocity profiles of the interaction of two pH buffer solutions (pH 4 and 10) through the designed microfluidic chip were qualitatively estimated from experimental data analysis and validated with the simulation results obtained from the CFD-influenced ANSYS Fluent tool.http://dx.doi.org/10.1063/5.0056597 |
| spellingShingle | Feroz Ahmed Yuichi Yoshida Jin Wang Kenji Sakai Toshihiko Kiwa Design and validation of microfluidic parameters of a microfluidic chip using fluid dynamics AIP Advances |
| title | Design and validation of microfluidic parameters of a microfluidic chip using fluid dynamics |
| title_full | Design and validation of microfluidic parameters of a microfluidic chip using fluid dynamics |
| title_fullStr | Design and validation of microfluidic parameters of a microfluidic chip using fluid dynamics |
| title_full_unstemmed | Design and validation of microfluidic parameters of a microfluidic chip using fluid dynamics |
| title_short | Design and validation of microfluidic parameters of a microfluidic chip using fluid dynamics |
| title_sort | design and validation of microfluidic parameters of a microfluidic chip using fluid dynamics |
| url | http://dx.doi.org/10.1063/5.0056597 |
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